Results 121 to 130 of about 26,464 (199)

The Role of Mitochondrial Dysfunction and Inflammatory Response in the Pathogenesis of Sepsis-Induced Myocardial Injury: A Mechanistic Study

Journal of Inflammation Research
An-Bu Liu,1– 3 Sheng Wang,4 Yue Shen,4 Lei Ma,1 Jun-Fei Zhang1,3 1Department of Emergency Medical, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 2State Key Laboratory of Pathogenesis, Prevention and ...
Liu AB, Wang S, Shen Y, Ma L, Zhang JF
doaj  

Impact of Prior Angiotensin‐Converting Enzyme Inhibitor and Angiotensin II Receptor Blocker Use on Delirium Incidence in ICU Patients: A Retrospective Study

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims This investigation aimed at exploring the impact that the pre‐existing use of angiotensin‐converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) has on the incidence of delirium in patients within the intensive care unit (ICU).
Zhe Li, Shuo Liu, Qihai Wan, Yahui Niu, Yi Yu   +4 more
wiley   +1 more source

Research Progress on Anti‐Inflammatory Adipokine SFRP5‐Mediated Lipid Metabolism and Its Potential Role in Neural Development

Immunity, Inflammation and Disease, Volume 14, Issue 6, June 2026.
ABSTRACT Objective To systematically review the structural features of secreted frizzled‑related protein 5 (SFRP5) and its dual regulation of canonical/non‑canonical Wnt signaling, analyze its association with metabolic disorders, and specifically explore the role and mechanisms of the SFRP5–lipid metabolism axis in neural and optic nerve development ...
Qianfang Jia, Zihan Li, Tianyi Yang, Weihua Yang, Wei Chi   +4 more
wiley   +1 more source

Validation of Senescence of the Role of ATM/P53 Pathway in Myocardial Senescence in Mice with Sepsis

Infection and Drug Resistance
Zhonghan Yan,1,* Xuemei Shi,1,* Ruilin Ding,2 Fenfen Xia,1 Yan Du,3 Xiaojie Wang,4 Qing Peng1 1Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 2Institute of Drug ...
Yan Z, Shi X, Ding R, Xia F, Du Y, Wang X, Peng Q   +6 more
doaj  

Venous Thromboembolism (VTE) Risk Stratification in Otolaryngology: Socioeconomic and Subspecialty Insights

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 3, June 2026.
ABSTRACT Objective Venous thromboembolism (VTE) is a leading cause of preventable perioperative mortality in otolaryngology, highlighting the urgent need for validated risk assessments such as the Caprini score to guide prophylaxis and enhance patient safety.
Corinne A. Pittman, Hudson Liu, Lovedeep Singh, Serenity G. Budd, Sabrina Heman‐Ackah, Selena E. Briggs   +5 more
wiley   +1 more source

The Role of N6‐Methyladenosine Modification in Health and Disease

MedComm, Volume 7, Issue 6, June 2026.
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li, Yuanhai Sun, Wanfang Zheng, Lingqin Li, Yaqian Feng, Minyou Qi, Hanbing Li   +6 more
wiley   +1 more source

Epigenetic Regulation in Cardiovascular Diseases: Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 6, June 2026.
Environmental and lifestyle exposures reshape the cardiovascular epigenome through coordinated regulation of DNA methylation, histone modifications, noncoding RNAs, and RNA methylation (m6A). These multilayered mechanisms drive enhancer‐centered regulatory network remodeling and epigenomic plasticity in cardiovascular diseases, highlighting emerging ...
Wangzheqi Zhang, Chenyang Mu, Rui Zhao, Runwei Ma, Xuehai Liu, Haoling Zhang, Zengwu Wang, Jing‐jing Zhang   +7 more
wiley   +1 more source

Amphiregulin attenuates sepsis-induced myocardial dysfunction by maintaining the localization of connexin43. [PDF]

Inflamm Regen
Chen M, Takamori S, Isayama K, Wang Y, Matsunaga S, Narahara S, Honsho M, Murata M, Kinugawa S, Abe K, Akahoshi T.   +10 more
europepmc   +1 more source

VDAC2 malonylation participates in sepsis-induced myocardial dysfunction via mitochondrial-related ferroptosis. [PDF]

Int J Biol Sci, 2023
She H, Tan L, Du Y, Zhou Y, Guo N, Zhang J, Du Y, Wang Y, Wu Z, Ma C, Li Q, Mao Q, Hu Y, Liu L, Li T.   +14 more
europepmc   +1 more source

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source