Results 91 to 100 of about 930 (139)

Elucidation of the mechanisms and cellular factors involved in the intracellular redistribution of SERINC5 promoted by HIV-1 Nef

SERINC5 é um fator de restrição que diminui drasticamente a infecciosidade do HIV-1. Expresso na membrana plasmática, SERINC5 é incorporado nas partículas virais recém-sintetizadas, comprometendo a capacidade desses vírus de infectar uma nova célula-alvo.
Costa, Cristina Santos da
core   +1 more source

SIVcol Nef relocalizes SERINC5 to the proteasome by an Y86 dependent mechanism.

, 2018
(A) Representative Laser scanning confocal microscopy images of JTAg SERINC3/5 knock-out cells transfected with SERINC5–GFP (S5-GFP; green) alone or together with the indicated AU1-tagged Nef proteins (red). Endogenous lysosomes were stained with an anti-
Christina M. Stürzel (3752773), Frank Kirchhoff (94157), Igor Stagljar (42523), Vânia Passos (5646386), Oliver T. Fackler (36453), Daniel Sauter (109619), Dorota Kmiec (5646374), Zhong Yao (361911), Thomas Zillinger (408718), Birthe Trautz (5646383), Dominik Hotter (4405666), Konstantin M. J. Sparrer (553762), Christine Goffinet (90029), Bengisu Akbil (5646377), Swetha Ananth (5646380), Ahidjo Ayouba (256440), Martine Peeters (50360)   +16 more
core   +1 more source

Beyond Impairment of Virion Infectivity: New Activities of the Anti-HIV Host Cell Factor SERINC5

Viruses
Members of the serine incorporator (SERINC) protein family exert broad antiviral activity, and many viruses encode SERINC antagonists to circumvent these restrictions.
Samy Sid Ahmed, Kathrin Bajak, Oliver T. Fackler   +2 more
doaj   +1 more source

Actions of HIV-1 Nef on the intracellular trafficking machinery to counteract the restriction factor SERINC5

Nef é uma proteína acessória codificada pelo HIV-1 que aumenta a infectividade das partículas virais. Nef subverte a maquinaria de tráfego de proteínas para robustamente fazer a regulação negativa de moléculas da superfície celular (incluindo CD4 e MHC-I)
Czernisz, Érika da Silva
core   +1 more source

Disruption of Transmembrane Phosphatidylserine Asymmetry by HIV-1 Incorporated SERINC5 Is Not Responsible for Virus Restriction

Biomolecules
Host restriction factor SERINC5 (SER5) incorporates into the HIV-1 membrane and inhibits infectivity by a poorly understood mechanism. Recently, SER5 was found to exhibit scramblase-like activity leading to the externalization of phosphatidylserine (PS ...
Gokul Raghunath, Elizabeth H. Abbott, Mariana Marin, Hui Wu, Judith Mary Reyes Ballista, Melinda A. Brindley, Gregory B. Melikyan   +6 more
doaj   +1 more source

Relative resistance of patient-derived envelope sequences to SERINC5-mediated restriction of HIV-1 infectivity. [PDF]

J Virol, 2023
Nkuwi E, Judicate GP, Tan TS, Barabona G, Toyoda M, Sunguya B, Kamori D, Ueno T.   +7 more
europepmc   +1 more source

Investigating transmitted/founder HIV-1 nef and env effects on SERINC5 inhibition of infectivity [PDF]

, 2017
HIV has killed millions of people since its discovery in the 1980s and continues to be a costly disease that affects millions worldwide. The advent of antiretroviral drug-therapy made this once deadly disease manageable through a daily regimen of drugs ...
Chau, Jasmine
core  

Phylogenetic Reconstruction and Functional Characterization of the Ancestral Nef Protein of Primate Lentiviruses. [PDF]

Mol Biol Evol, 2023
Olabode AS, Mumby MJ, Wild TA, Muñoz-Baena L, Dikeakos JD, Poon AFY.   +5 more
europepmc   +1 more source

The potency of Nef-mediated SERINC5 antagonism correlates with the prevalence of primate lentiviruses in the wild

, 2016
The cellular factor serine incorporator 5 (SERINC5) impairs HIV-1 infectivity but is antagonized by the viral Nef protein. We analyzed the anti-SERINC5 activity of Nef proteins across primate lentiviruses and examined whether SERINC5 represents a barrier
Kirchhoff, F., Sauter, D., Learn, G. H., Kmiec, D., Peeters, Martine, Langer, S., Pizzato, M., Regensburger, K., Peiffer, L., Hahn, B. H., Heigele, A., Sturzel, C. M.   +11 more
core  

Genetic and transcriptomic signatures of host control in HIV-1 infection. [PDF]

Retrovirology
Oreshkov S, Thorball CW, Meylan J, Muriset M, Calmy A, Ciuffi A, Elzi L, Nemeth J, Muhammad A, Baumann L, Schmid P, Stöckle M, Alpern D, Swiss HIV Cohort Study, Fellay J, Santoni F.   +15 more
europepmc   +1 more source