Results 81 to 90 of about 930 (139)
Effects of SERINC5 on pseudovirus infectivity.
, 2022 A-C: Pesudoviruses were produced using ΔEnv/NefWT HIV-1NL4-3 that contains the wild type Nef, bearing Env (HXB2), Env (YU-2), VSV-G, or HA/NA, in the presence of different amounts of SERINC5 plasmid DNA.
Zhangling Fan (12095869) +14 more
core +1 more source
HA glycosylation modulates sensitivity to SERINC5 restriction.
, 2022 A: Statistical analysis of the N-glycosylation site numbers in HA head domain (90 to 240). B: Statistical analysis of the single N-glycosylation site in 160/162 position.
Zhangling Fan (12095869) +14 more
core +1 more source
HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation
, 2015 HIV-1 Nef, a protein important for the development of AIDS, has well-characterized effects on host membrane trafficking and receptor downregulation. By an unidentified mechanism, Nef increases the intrinsic infectivity of HIV-1 virions in a host-cell ...
Santoni, Federico +23 more
core +1 more source
Viruses, 2015 The Nef protein is an accessory gene product encoded by human immunodeficiency virus types 1 and 2 (HIV-1/-2) and simian immunodeficiency virus (SIV) that boosts virus replication in the infected host and accelerates disease progression. Unlike the HIV-1
Oliver T. Fackler
doaj +1 more source
Plasma Membrane-Associated Restriction Factors and Their Counteraction by HIV-1 Accessory Proteins
Cells, 2019 The plasma membrane is a site of conflict between host defenses and many viruses. One aspect of this conflict is the host’s attempt to eliminate infected cells using innate and adaptive cell-mediated immune mechanisms that recognize features of the
Peter W. Ramirez +5 more
doaj +1 more source
Elucidating the mechanisms of HIV-1 antiviral activity by SERINC5
, 2017 The serine incorporators (SERINC) are a highly conserved transmembrane protein family in eukaryotes that are known to play an important role in stimulating lipid biosynthesis in a variety of cells. As their name suggests, they activate phosphatidylserine
Moumneh, Khaled
core
HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation
, 2016 HIV-1 Nef, a protein important for the development of AIDS, has well-characterized effects on host membrane trafficking and receptor downregulation. By an unidentified mechanism, Nef increases the intrinsic infectivity of HIV-1 virions in a host-cell ...
Luban, Jeremy +11 more
core +1 more source
SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef
, 2015 HIV-1 Nef and the unrelated mouse leukaemia virus glycosylated Gag (glycoGag) strongly enhance the infectivity of HIV-1 virions produced in certain cell types in a clathrin-dependent manner. Here we show that Nef and glycoGag prevent the incorporation of
Wu, Yuanfei +2 more
core +1 more source
Role of HIV-1 Nef dimerization in SERINC5 restriction factor antagonism and Src-family kinase recruitment [PDF]
, 2020 The HIV-1 Nef accessory protein plays a prominent role in viral pathogenesis, immune evasion of HIV-infected cells, and AIDS progression. Nef lacks intrinsic biochemical activity, and instead functions through interactions with multiple host cell ...
Staudt, Ryan P
core