Results 71 to 80 of about 930 (139)
A Conserved Acidic-Cluster Motif in SERINC5 Confers Partial Resistance to Antagonism by HIV-1 Nef [PDF]
, 2020 The cellular protein SERINC5 inhibits the infectivity of diverse retroviruses, and its activity is counteracted by the glycosylated Gag (glycoGag) protein of murine leukemia virus (MLV), the S2 protein of equine infectious anemia virus (EIAV), and the ...
Guatelli, John +8 more
core +1 more source
Advanced Science, Volume 11, Issue 47, December 18, 2024.It is found that tooth morphogenesis is regulated by a combination of mechanical niches and biochemical signaling, as revealed by a comprehensive map of tooth development using high‐throughput spatial transcriptome and single‐cell RNA sequencing. These findings establish a fundamental basis for understanding these essential elements, which could ...
Shengjie Jiang +7 more
wiley +1 more source
, 2023 Serine incorporator protein 5 (SERINC5) is a key innate immunity factor that operates in the cell to restrict the infectivity of certain viruses. Different viruses have developed strategies to antagonize SERINC5 function but, how SERINC5 is controlled ...
Francisco J. Iborra (14632871) +12 more
core +1 more source
Clinical glycoproteomics: methods and diseases
MedComm, Volume 5, Issue 10, October 2024.An overview of clinical glycoproteomics: methods and diseases. The primary types of glycosylations include N‐glycosylation and O‐glycosylation. Three main glycoproteomic strategies are employed, with the bottom‐up approach being the most commonly utilized.
Yujia Wang +3 more
wiley +1 more source
, 2023 Serine incorporator protein 5 (SERINC5) is a key innate immunity factor that operates in the cell to restrict the infectivity of certain viruses. Different viruses have developed strategies to antagonize SERINC5 function but, how SERINC5 is controlled ...
Francisco J. Iborra (14632871) +12 more
core +1 more source
Quantitative proteomics unveils known and previously unrecognized alterations in neuropathic nerves
Journal of Neurochemistry, Volume 168, Issue 9, Page 3154-3170, September 2024.This study was designed to obtain comprehensive quantitative proteomic data from the sciatic nerves of Trembler J (TrJ) mice that model Charcot–Marie‐Tooth type 1E (CMT1E) hereditary peripheral neuropathy. Samples from three‐week old, wild‐type (Wt), and neuropathic mice, of mixed sexes, were analyzed.
Victoria Defilippi +3 more
wiley +1 more source
Human MARCH1, 2, and 8 block Ebola virus envelope glycoprotein cleavage via targeting furin P domain
Journal of Medical Virology, Volume 96, Issue 2, February 2024.Abstract Membrane‐associated RING‐CH (MARCH) family proteins were recently reported to inhibit viral replication through multiple modes. Previous work showed that human MARCH8 blocked Ebola virus (EBOV) glycoprotein (GP) maturation. Our study here demonstrates that human MARCH1 and MARCH2 share a similar pattern to MARCH8 in restricting EBOV GP ...
Changqing Yu +10 more
wiley +1 more source
Retrovirology, 2020 The HIV accessory protein Nef downregulates the viral entry receptor CD4, the Human Leukocyte Antigen (HLA)-A and -B molecules, the Serine incorporator 5 (SERINC5) protein and other molecules from the infected cell surface, thereby promoting viral ...
Hanwei Sudderuddin +8 more
doaj +1 more source
Frontiers in Immunology, 2019 Current combined antiretroviral therapy (cART) mainly targets 3 of the 15 HIV proteins leaving many potential viral vulnerabilities unexploited. To purge the HIV-1 latent reservoir, various strategies including “shock and kill” have been developed. A key
Bingfeng Liu +23 more
doaj +1 more source
Effect of SIVcol Nef on SERINC5 expression and virion incorporation.
, 2018 (A) The upper panel shows the infectivity of HIV-1 particles produced in HEK293T cells relative to the nef-defective control vector (100%). The lower panel shows Western blot analysis of lysates of the corresponding producer cells and purified virions ...
Christina M. Stürzel (3752773) +16 more
core +1 more source