Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Diabetes mellitus (DM) and chronic kidney disease (CKD) frequently coexist and together create a ‘triple threat’ with dyslipidaemia, enhancing the risk for cardiovascular morbidity and mortality. Diabetic kidney disease (DKD) leads to altered lipid metabolism through insulin resistance, inflammation and oxidative stress resulting in an ...
Ann S. Forrest +3 more
wiley +1 more source
Dapagliflozin Alters Plasma Metabolome in Patients With Type 1 Diabetes During Ketosis
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims Use of sodium‐glucose cotransporter 2 inhibitors (SGLT2i) in patients with type 1 diabetes (T1D) is limited by increased risk of ketoacidosis. We aimed to determine metabolic pathways affected by SGLT2i treatment in adults with T1D during ketosis induced by insulin withdrawal.
Rosa Yang +6 more
wiley +1 more source
Disruption of cysteine metabolism leads to synthetic lethality and <i>in vivo</i> fitness impairment in <i>Acinetobacter baumannii</i>. [PDF]
mBioPathak A, Saini S, Pathania R.
europepmc +1 more source
The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1
The FEBS Journal, EarlyView.ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu +2 more
wiley +1 more source
Three metabolic pathways replenishing the one-carbon pool collectively support growth and virulence of <i>Listeria monocytogenes</i>. [PDF]
ElifeFreier S +9 more
europepmc +1 more source
The FEBS Journal, EarlyView.Vitamin B6 is a critical molecule for plant metabolism and development. Rsr4‐1, a loss‐of‐function mutant in a vitamin B6 biosynthesis gene, has a distinct short root phenotype. Here we describe five novel suppressor mutants with an rsr4‐1 background that have normalized root growth and distinct phenotypic and molecular characteristics, representing a ...
Marcelina Parra +4 more
wiley +1 more source
Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle
The FEBS Journal, EarlyView.EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini +4 more
wiley +1 more source
Beyond native reactivity: radical SAM enzymes as platforms for new-to-nature chemistry. [PDF]
RSC Chem BiolLiu X +5 more
europepmc +1 more source
Transcriptional Reshaping of Bacteriocytes in the Aphid-<i>Serratia</i> Symbiosis. [PDF]
InsectsChen Y +6 more
europepmc +1 more source
Metabolic Footprint of Drosophila S2 Cells: Findings During the Production of a Recombinant Rabies Virus Glycoprotein. [PDF]
Biotechnol JDecarli MC +6 more
europepmc +1 more source