Yersinia ruckeri is the causative agent of enteric redmouth disease in salmonids. In fish, the intestine represents an important site of nutrient uptake, host–pathogen interactions, and defense.
Gokhlesh Kumar+3 more
doaj +1 more source
Proteases that degrade the biofilm matrix
Biofilms protect bacteria from the action of antibacterial drugs and are one of the mechanisms of antibiotic resistance of infections. Destruction of the bacterial biofilm matrix leads to the release of bacteria and they again become vulnerable to ...
А.Е. Abaturov
doaj +1 more source
On nonemptiness of Newton strata in the $B_\mathrm{dR}^+$-Grassmannian for $\mathrm{GSp}_{2n}$ [PDF]
We build upon our previous work to study the Newton stratification on the $B_\mathrm{dR}^+$-Grassmannian for $\mathrm{GSp}_{2n}$. Our main result gives an explicit classification of all nonempty Newton strata associated to a Frobenius-conjugacy class satisfying certain conditions on the Newton polygon.
arxiv
Amino acid frequency and domain features serve well for random forest based classification of thermophilic and mesophilic protein; a case study on serine proteases [PDF]
Thermostability is an important prerequisite for enzymes employed for industrial applications. Several machine learning based models have thus been formulated for protein classification based on this particular trait. These models have employed features derived from sequences, structures or both resulting in a >93% accuracy based on a 10-fold cross ...
arxiv
The recent identification of catalytically active peptidylglycine α-amidating monooxygenase (PAM) in Chlamydomonas reinhardtii, a unicellular green alga, suggested the presence of a PAM-like gene and peptidergic signaling in the last eukaryotic ...
Raj Luxmi+6 more
doaj +1 more source
Investigation of the impact of PTMs on the protein backbone conformation [PDF]
Post-Translational Modifications (PTMs) are known to play a critical role in the regulation of the protein functions. Their impact on protein structures, and their link to disorder regions have already been spotted on the past decade. Nonetheless, the high diversity of PTMs types, and the multiple schemes of protein modifications (multiple PTMs, of ...
arxiv +1 more source
Papain-like proteases: Applications of their inhibitors [PDF]
Proteases are one of the most important classes of enzyme and expressed throughout the animal and plant kingdoms as well as in viruses and bacteria.
Dubey, VK+3 more
core +2 more sources
Pharmaceutically modified subtilisins withstand acidic conditions and effectively degrade gluten in vivo [PDF]
Detoxification of gluten immunogenic epitopes is a promising strategy for the treatment of celiac disease. Our previous studies have shown that these epitopes can be degraded in vitro by subtilisin enzymes derived from Rothia mucilaginosa, a natural ...
Darwish, Ghassan+4 more
core +1 more source
Functional characterization of a subtilisin-like serine protease from Vibrio cholerae
Vibrio cholerae, the causative agent of the human diarrheal disease cholera, exports numerous enzymes that facilitate its adaptation to both intestinal and aquatic niches.
M. Howell+4 more
semanticscholar +1 more source
On nonemptiness of Newton strata in the $B_\mathrm{dR}^+$-Grassmannian for $\mathrm{GL}_n$ [PDF]
We study the Newton stratification in the $B_\mathrm{dR}^+$-Grassmannian for $\mathrm{GL}_n$ associated to an arbitrary (possibly nonbasic) element of $B(\mathrm{GL}_n)$. Our main result classifies all nonempty Newton strata in an arbitrary minuscule Schubert cell. For a large class of elements in $B(\mathrm{GL}_n)$, our classification is given by some
arxiv