Podocytes as novel sources of neutrophil serine proteases: expression and regulation by inflammatory molecular patterns [PDF]
Cellular and Molecular Life SciencesPodocytes are essential components of the glomerular filtration barrier and are increasingly recognized as immunologically active cells. Here, we demonstrate that human and rat podocytes express enzymatically active neutrophil serine proteases (NSPs ...
Aleksandra Wróblewska-Schmude +10 more
doaj +2 more sources
A Clinical Update on SARS-CoV-2: Pathology and Development of Potential Inhibitors
Current Issues in Molecular Biology, 2023 SARS-CoV-2 (severe acute respiratory syndrome) is highly infectious and causes severe acute respiratory distress syndrome (SARD), immune suppression, and multi-organ failure. For SARS-CoV-2, only supportive treatment options are available, such as oxygen
Desh Deepak Singh +3 more
doaj +1 more source
Pest protection conferred by a Beta vulgaris serine proteinase inhibitor gene. [PDF]
PLoS ONE, 2013 Proteinase inhibitors provide a means of engineering plant resistance to insect pests. A Beta vulgaris serine proteinase inhibitor gene (BvSTI) was fused to the constitutive CaMV35S promoter for over-expression in Nicotiana benthamiana plants to study ...
Ann C Smigocki +3 more
doaj +1 more source
AbetaPP/APLP2 family of Kunitz serine proteinase inhibitors regulate cerebral thrombosis. [PDF]
J Neurosci, 2009 Xu F +5 more
europepmc +3 more sources
Non‐peptide inhibitors of HCV serine proteinase [PDF]
FEBS Letters, 1998 We screened a chemical library of 2000 compounds for inhibitors of hepatitis C virus (HCV) serine proteinase using an in vitro screening method measuring the hydrolysis of the peptide substrate. Three compounds were found to be the most potent inhibitors (IC50<10−5 M).
Kakiuchi, Nobuko +6 more
openaire +2 more sources
The effect of melanin on the proteolytic potential of blood under alkali esophageal burn
Journal of Biological Research, 2020 Caustic esophageal burns are among serious medical problems of global significance. Due to a key role in biological processes proteolytic enzymes actively involved in the pathological mechanisms underpinning the development and progression of burn ...
Nataliia Chornenka +9 more
doaj +1 more source
A KLK4 proteinase substrate capture approach to antagonize PAR1
Scientific Reports, 2021 Proteinase-activated receptor-1 (PAR1), triggered by thrombin and other serine proteinases such as tissue kallikrein-4 (KLK4), is a key driver of inflammation, tumor invasiveness and tumor metastasis.
Eitan Rabinovitch +8 more
doaj +1 more source
Frontiers in Chemistry, 2021 During inflammation neutrophils become activated and segregate neutrophil serine proteases (NSPs) to the surrounding environment in order to support a natural immune defense. However, an excess of proteolytic activity of NSPs can cause many complications,
Timo Burster +4 more
doaj +1 more source
Study on Serine Proteinase in the Muscle of Yesso Scallops (Mizuhopecten yessoensis）
Shipin gongye ke-ji, 2022 To investigate the effect of endogenous protease on the texture of Yesso scallop muscle during cold storage, the texture and protein change related indexes of Yesso scallop muscle was measured during 4 ℃ cold storage 7 d with a purpose to identify the ...
Qiuying REN +6 more
doaj +1 more source
Identification of three stage-specific proteinases of Plasmodium falciparum. [PDF]
, 1987 We have identified and characterized three stage-specific proteinases of Plasmodium falciparum that are active at neutral pH. We analyzed ring-, trophozoite-, schizont-, and merozoite-stage parasites by gelatin substrate PAGE and characterized the ...
Kim, K +3 more
core +2 more sources