The under-appreciated world of the serpin family of serine proteinase inhibitors. [PDF]
EMBO Mol Med, 2023 In the practice of medicine, many fundamental biological pathways that require tight on/off control, such as inflammation and circulatory homeostasis, are regulated by serine proteinases, but we rarely consider the unique protease inhibitors that, in ...
Bouton MC +9 more
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Kazal-type serine proteinase inhibitors in the midgut of Phlebotomus papatasi. [PDF]
Mem Inst Oswaldo Cruz, 2013 Sandflies (Diptera: Psychodidae) are important disease vectors of parasites of the genus Leishmania, as well as bacteria and viruses. Following studies of the midgut transcriptome of Phlebotomus papatasi, the principal vector of Leishmania major, two non-
Sigle LT, Ramalho-Ortigão M.
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Primary Structure of Potato Kunitz-Type Serine Proteinase Inhibitor [PDF]
Biological Chemistry, 2000 The serine proteinase inhibitor (PSPI-21) isolated from potato tubers (Solanum tuberosum L.) comprises two protein species with pI 5.2 and 6.3, denoted as PSPI-21-5.2 and PSPI-21-6.3, respectively. They were separated by anion exchange chromatography on a Mono Q FPLC column.
Tatyana A. Valueva +3 more
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Serine proteinases and their inhibitors in Phycomyces blakesleeanus.
Journal of Biological Chemistry, 1979 Three serine proteinases of Phycomyces blakesleeanus were isolated and characterized. The molecular weights were determined to be 18,000, 22,000, and 60,000. The proteinases were solubilized by detergent or salt treatment. Two soluble proteins that specifically inhibit these proteinases were also isolated and characterized. Both these proteins formed 1:
Eckhard Fischer, Klaus-Sten Thomson
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Squash inhibitor family of serine proteinases.
Acta Biochimica Polonica, 1996 Squash inhibitors of serine proteinases form an uniform family of small proteins. They are built of 27-33 amino-acid residues and cross-linked with three disulfide bridges. The reactive site peptide bond (P1-P1') is between residue 5 (Lys, Arg or Leu) and 6 (always Ile). High resolution X-ray structures are available for two squash inhibitors complexed
Jacek Otlewski, Daniel Krowarsch
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Analysis of serine proteinase–inhibitor interaction by alanine shaving [PDF]
Protein Science, 2002 AbstractWe analyzed the energetic importance of residues surrounding the hot spot (the P1 position) of bovine pancreatic trypsin inhibitor (BPTI) in interaction with two proteinases, trypsin and chymotrypsin, by a procedure called molecular shaving.
Olga Buczek +4 more
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Comparative Transcriptome Analysis Reveals Expression of Defense Pathways and Specific Protease Inhibitor Genes in Solanum lycopersicum in Response to Feeding by Tuta absoluta. [PDF]
InsectsUnderstanding plant-insect interactions can help control the harm of herbivorous pests. According to transcriptome data, transcripts of Solanum lycopersicum responding to feeding by Tuta absoluta were screened for important endopeptidase inhibitors ...
Zhou Y, Pan Y, Liu J, Yang W, Shen G.
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The evolution of a genetic locus encoding small serine proteinase inhibitors [PDF]
Biochemical and Biophysical Research Communications, 2005 We previously identified a locus on human chromosome 20 that encompasses 14 genes of postulated WFDC-type proteinase inhibitors with a potential role in innate immunity. In an extended study, homologous loci are here described on mouse chromosome 2, rat chromosome 3, and dog chromosome 24.
Adam Clauss, Hans Lilja, Åke Lundwall
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Serine proteinase inhibitors from insect hemolymph.
Acta Biochimica Polonica, 1996 Insect hemolymph, like vertebrate serum, contains several different types of polypeptides that are able to inhibit the catalytic function of proteolytic enzymes, however studies on proteins possessing this capability have been limited to a relatively few species.
Antoni Polanowski, Tadeusz Wilusz
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In-silico comparative study of inhibitory mechanism of Plant Serine Proteinase Inhibitors. [PDF]
Bioinformation, 2012 Siva Prasad CV +3 more
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