Results 91 to 100 of about 24,818 (268)
Mechanistic behaviour and molecular interactions of heat shock protein 47 (HSP47) [PDF]
, 2012 This project involves the study of heat shock protein 47 (HSP47), which is a molecular chaperone crucial for collagen biosynthesis. It exhibits a high degree of sequence homology with members of the serine protease inhibitor (serpin) superfamily, though ...
Abdul Wahab, Mohd Firdaus +1 more
core +1 more source
The stability and activity of human neuroserpin are modulated by a salt bridge that stabilises the reactive centre loop [PDF]
, 2015 Neuroserpin (NS) is an inhibitory protein belonging to the serpin family and involved in several pathologies, including the dementia Familial Encephalopathy with Neuroserpin Inclusion Bodies (FENIB), a genetic neurodegenerative disease caused by ...
Caccia, Sonia +7 more
core +1 more source
The intracellular serpin family.
Acta Biochimica Polonica, 1996 The serpins are widely distributed, structurally related family of proteins with diverse functions. Most of the known serpins are proteinase inhibitors, the majority being found as secreted species, however, there are a few that occur intracellularly and their physiological role remains unknown.
Adam Dubin, Renata Korpula-Mastalerz
openaire +4 more sources
Toxins, 2021 Hemostatic disorders are caused either by platelet-related dysfunctions, defective blood coagulation, or by a combination of both, leading to an increased susceptibility to cardiovascular diseases (CVD) and other related illnesses. The unique specificity
Hajer Aounallah +8 more
doaj +1 more source
Molecular Pharmaceutics, 2016 Wound care is a serious healthcare concern, often complicated by prolonged inflammation and bacterial infection, which contributes significantly to mortality and morbidity.
Miral Fumakia, E. Ho
semanticscholar +1 more source
Advanced Science, EarlyView.Triple‐negative breast cancer (TNBC) remains a major challenge in breast cancer management as it lacks effective therapeutic targets. This study uncovers that MYC/TET3‐regulated mitochondrial inner‐membrane protein TMEM65 promotes TNBC progression and cisplatin resistance by activating the OXPHOS‐SERPINB3 pathway and reveals TMEM65 as a potential ...
Yin‐Ling Zhang +10 more
wiley +1 more source
Elevated cerebrospinal fluid levels of SERPIN E1 in participants with lewy body diseases
npj Parkinson's DiseaseParkinson’s disease (PD) exhibits substantial phenotypic variability, likely influenced, at least in part, by proteins associated with pathways integral to aging processes.
Milan Zimmermann +12 more
doaj +1 more source
Serpin peptidase inhibitor, clade E, member 2 in physiology and pathology: recent advancements
Frontiers in Molecular BiosciencesSerine protease inhibitors (serpins) are the most numerous and widespread multifunctional protease inhibitor superfamily and are expressed by all eukaryotes.
Shutong Wu +7 more
doaj +1 more source
OncoImmunology, 2018 Pediatric medulloblastomas are the most frequently diagnosed embryonal tumors of the central nervous system. Current therapies cause severe neurological and cognitive side effects including secondary malignancies.
Jeroen F. Vermeulen +10 more
doaj +1 more source
Expression of SERPINA3s in cattle: focus on bovSERPINA3-7 reveals specific involvement in skeletal muscle [PDF]
Open Biology, 2015 α1-Antichymotrypsin is encoded by the unique SERPINA3 gene in humans, while it is encoded by a cluster of eight closely related genes in cattle. BovSERPINA3 proteins present a high degree of similarity and significant divergences in the reactive centre ...
Antoine Péré-Brissaud +9 more
doaj +1 more source