Results 101 to 110 of about 24,818 (268)

Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor.

Blood, 2016
The complement system plays a key role in innate immunity, inflammation, and coagulation. The system is delicately balanced by negative regulatory mechanisms that modulate the host response to pathogen invasion and injury.
L. Wijeyewickrema, Emilie Lameignère, L. Hor, R. Duncan, T. Shiba, R. Travers, P. Kapopara, V. Lei, Stephanie A. Smith, Hugh Kim, J. Morrissey, R. Pike, E. Conway   +12 more
semanticscholar   +1 more source

Clinical Features, Molecular Biology, and the Metastatic Microenvironment in Lung Cancer Brain Metastases: Implications for Treatment Decisions

Advanced Science, EarlyView.
Brain metastases (BM) from lung cancer are aggressive with poor prognosis. This review covers clinical features, diagnosis, early metastasis, and multi‐omics‐elucidated mechanisms, especially the tumor microenvironment of lung cancer with BM. It also discusses preclinical models, signaling pathways, and emerging therapies.
Yixiang Zhu, Danming He, Zan Hou, Mei Lan, Ye Zhang, Qifeng Wang   +5 more
wiley   +1 more source

Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis. [PDF]

, 2016
The invasion-promoting MT1-MMP is a cell surface-associated collagenase with a plethora of critical cellular functions. There is a consensus that MT1-MMP is a key protease in aberrant pericellular proteolysis in migrating cancer cells and, accordingly, a
Cieplak, Piotr, Ge, Xin, Nam, Dong Hyun, Remacle, Albert G, Shiryaev, Sergey A, Strongin, Alex Y   +5 more
core   +1 more source

Identification and partial characterization of a novel serpin from Eudiplozoon nipponicum (Monogenea, Polyopisthocotylea)

Parasite, 2018
Background: Serpins are a superfamily of serine peptidase inhibitors that participate in the regulation of many physiological and cell peptidase-mediated processes in all organisms (e.g.
Pavel Roudnický, J. Vorel, J. Ilgova, M. Benovics, Adam Norek, L. Jedličková, L. Mikeš, D. Potěšil, Z. Zdráhal, J. Dvorak, M. Gelnar, M. Kašný   +11 more
semanticscholar   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Serpins in the Human Hair Follicle [PDF]

Journal of Investigative Dermatology, 2000
Proteinases and their inhibitors are very likely to function as mediators or regulators of the hair growth cycle. Very little information is currently available, however, regarding the specific inhibitors present in human hair follicles at defined stages of their growth cycle.
Pamela J. Jensen, Da Wen Yu, Tien Yang, Robert M. Lavker, Tung-Tien Sun, Barbara Risse, Mark S. Baker   +6 more
openaire   +2 more sources

Inhibition of yes-associated protein suppresses brain metastasis of human lung adenocarcinoma in a murine model. [PDF]

, 2018
Yes-associated protein (YAP) is a main mediator of the Hippo pathway and promotes cancer development and progression in human lung cancer. We sought to determine whether inhibition of YAP suppresses metastasis of human lung adenocarcinoma in a murine ...
Chan, Geraldine, Dai, Yuyuan, Hsu, Ping-Chih, Huang, Zhen, Jablons, David M, Liu, Shu, Miao, Jinbai, Urisman, Anatoly, Xu, Zhidong, Yang, Cheng-Ta, Yang, Yi-Lin, Yeh, Che-Chung, You, Joanna, You, Liang   +13 more
core   +1 more source

Protease: Serpin complexes to assess contact system and intrinsic pathway activation

Research and Practice in Thrombosis and Haemostasis, 2020
Mounting evidence suggests that a variety of disease states are pathophysiologically related to activation of the contact system in vivo. The plasma contact system is composed of a cascade of serine proteases initiated by surface activation of factor XII,
Michael W. Henderson, Denis F. Noubouossie, Anton Ilich, Kathy J. Wilson, Rafal Pawlinski, Dougald M. Monroe, Nigel S. Key   +6 more
doaj   +1 more source

A Venom Serpin Splicing Isoform of the Endoparasitoid Wasp Pteromalus puparum Suppresses Host Prophenoloxidase Cascade by Forming Complexes with Host Hemolymph Proteinases*

Journal of Biological Chemistry, 2016
To ensure successful parasitism, parasitoid wasps inject venom along with their eggs into their hosts. The venom serves to suppress host immune responses, including melanization.
Zhichao Yan, Qi Fang, Yang Liu, Shan Xiao, Lei Yang, Fei Wang, C. An, J. Werren, G. Yè   +8 more
semanticscholar   +1 more source

Antithrombin: Deficiency, Diversity, and the Future of Diagnostics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Our healthcare system provides reactive sick‐care, treating patients after symptoms have appeared by prescription of generic and often suboptimal therapy. This strategy brings along high costs and high pressure which is not sustainable.
Mirjam Kruijt, Christa M. Cobbaert, L. Renee Ruhaak   +2 more
wiley   +1 more source