Results 101 to 110 of about 43,231 (331)

SERPINs—From Trap to Treatment [PDF]

Frontiers in Medicine, 2019
Excessive enzyme activity often has pathological consequences. This for example is the case in thrombosis and hereditary angioedema, where serine proteases of the coagulation system and kallikrein-kinin system are excessively active. Serine proteases are controlled by SERPINs (serine protease inhibitors).
Sanrattana, Wariya, Maas, Coen, de Maat, Steven   +2 more
openaire   +4 more sources

Antithrombin: Deficiency, Diversity, and the Future of Diagnostics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Our healthcare system provides reactive sick‐care, treating patients after symptoms have appeared by prescription of generic and often suboptimal therapy. This strategy brings along high costs and high pressure which is not sustainable.
Mirjam Kruijt, Christa M. Cobbaert, L. Renee Ruhaak   +2 more
wiley   +1 more source

Regulatory mechanisms of reproduction in locusts and grasshoppers

New Plant Protection, EarlyView.
Regulatory networks composed of numerous coding and noncoding genes play crucial roles in the reproduction of locusts and grasshoppers. This review integrates mechanistic advances in reproductive regulation, highlighting environmentally adaptive pathways and providing prospective targets for eco‐friendly pesticides.
Jing He, Jiliang Wang, Xinran Wang
wiley   +1 more source

Characterization of Serpin Family Genes in Three Rice Planthopper Species and Their Expression Profiles in Response to Metarhizium Infection

Agronomy
Rice planthoppers, including Nilaparvata lugens, Sogatella furcifera, and Laodelphax striatellus, are major agricultural pests. Serpins, which function as serine protease inhibitors, play a pivotal role in the immune systems of these insects, especially ...
Ruonan Zhang, Zichun Zhong, Liyan He, Hongxin Wu, Liuyan He, Yujing Guo, Haoming Wu, Xiaoxia Xu, Fengliang Jin, Rui Pang   +9 more
doaj   +1 more source

RNA binding protein HuD mediates the crosstalk between β cells and islet endothelial cells by the regulation of Endostatin and Serpin E1 expression

Cell Death and Disease, 2022
RNA binding protein HuD plays essential roles in gene expression by regulating RNA metabolism, and its dysregulation is involved in the pathogenesis of several diseases, including tumors, neurodegenerative diseases, and diabetes.
Myeongwoo Jung, Seungyeon Ryu, Chongtae Kim, Seongho Cha, Hoin Kang, Eunbyul Ji, Youlim Hong, Youngjoon Lee, Sukyoung Han, Seung Min Jeong, Wook Kim, Eun Kyung Lee   +11 more
doaj   +1 more source

Identification and partial characterization of a novel serpin from Eudiplozoon nipponicum (Monogenea, Polyopisthocotylea)

Parasite, 2018
Background: Serpins are a superfamily of serine peptidase inhibitors that participate in the regulation of many physiological and cell peptidase-mediated processes in all organisms (e.g.
Pavel Roudnický, J. Vorel, J. Ilgova, M. Benovics, Adam Norek, L. Jedličková, L. Mikeš, D. Potěšil, Z. Zdráhal, J. Dvorak, M. Gelnar, M. Kašný   +11 more
semanticscholar   +1 more source

Differential Proteomics of Large Extracellular Vesicles in Ovarian Cancer

PROTEOMICS, EarlyView.
ABSTRACT Diverse extracellular vesicles (EVs) are present in all body fluids; however, knowledge of large EVs (lEVs) remains limited. Molecular EV profiles vary depending on EV size and the physiological circulatory system, even within the same patient. In this study, we aimed to characterize the proteomic profile of IEVs in ovarian cancer patients and
Kazuhiro Suzuki, Yusuke Yamamoto, Masami Kitagawa, Eri Asano‐Inami, Kosuke Yoshida, Hiroaki Kajiyama, Akira Yokoi   +6 more
wiley   +1 more source

Schistosome serine protease inhibitors: parasite defense or homeostasis?

Anais da Academia Brasileira de Ciências, 2011
Serpins are a structurally conserved family of macromolecular inhibitors found in numerous biological systems. The completion and annotation of the genomes of Schistosoma mansoni and Schistosoma japonicum has enabled the identification by phylogenetic ...
Landys A. Lopez Quezada, James H McKerrow   +1 more
doaj   +1 more source

Protease: Serpin complexes to assess contact system and intrinsic pathway activation

Research and Practice in Thrombosis and Haemostasis, 2020
Mounting evidence suggests that a variety of disease states are pathophysiologically related to activation of the contact system in vivo. The plasma contact system is composed of a cascade of serine proteases initiated by surface activation of factor XII,
Michael W. Henderson, Denis F. Noubouossie, Anton Ilich, Kathy J. Wilson, Rafal Pawlinski, Dougald M. Monroe, Nigel S. Key   +6 more
doaj   +1 more source

Therapeutic SERPINs: Improving on Nature [PDF]

, 2021
Coen Maas, Steven de Maat
openalex   +1 more source