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Severe malaria [PDF]

Malaria Journal, 2022
Severe malaria is a medical emergency. It is a major cause of preventable childhood death in tropical countries. Severe malaria justifies considerable global investment in malaria control and elimination yet, increasingly, international agencies, funders
Nicholas J. White
doaj   +3 more sources

Severe malaria intervention status in Nigeria: workshop meeting report [PDF]

Malaria Journal
Nigeria accounts for 39% of global malaria deaths in children under 5 years of age and the effective management of severe malaria is a health priority.
Emmanuel Shekarau, Miriam Uzoanya, Nnenna Ogbulafor, Severe Malaria Working Group   +3 more
doaj   +2 more sources

Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domains [PDF]

EMBO Molecular Medicine, 2016
Most severe Plasmodium falciparum infections are experienced by young children. Severe symptoms are precipitated by vascular sequestration of parasites expressing a particular subset of the polymorphic P. falciparum erythrocyte membrane protein 1 (PfEMP1)
Barry AE, Baruch DI, Bent Petersen, Chen Q, Christian W Wang, Daniel TR Minja, Jakob S Jespersen, Jens EV Petersen, John PA Lusingu, Louise Turner, MacPherson GG, Rowe JA, Sixbert I Mkumbaye, Thomas Lavstsen, Thor G Theander   +14 more
core   +2 more sources

Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach. [PDF]

American Journal of Tropical Medicine and Hygiene, 2015
More than a century after the discovery of Plasmodium spp. parasites, the pathogenesis of severe malaria is still not well understood. The majority of malaria cases are caused by Plasmodium falciparum and Plasmodium vivax, which differ in virulence, red ...
Arevalo-Herrera, Myriam, Duraisingh, Manoj T, Mishra, Saroj K, Mohanty, Sanjib, Rathod, Pradipsinh K, Smith, Joseph D, Taylor, Terrie E, Wassmer, Samuel C   +7 more
core   +2 more sources

Severe malaria: what's new on the pathogenesis front? [PDF]

International Journal of Parasitology, 2016
Plasmodium falciparum causes the most severe and fatal form of malaria in humans with over half a million deaths each year. Cerebral malaria, a complex neurological syndrome of severe falciparum malaria, is often fatal and represents a major public ...
Grau, Georges Emile Raymond, Wassmer, Samuel Crocodile   +1 more
core   +2 more sources

Gradual acquisition of immunity to severe malaria with increasing exposure [PDF]

Proceedings of the Royal Society B: Biological Sciences, 2014
Previous analyses have suggested that immunity to non-cerebral severe malaria due to Plasmodium falciparum is acquired after only a few infections, whereas longitudinal studies show that some children experience multiple episodes of severe disease ...
Drakeley, CJ, Ghani, AC, Griffin, JT, Hollingsworth, TD, Reyburn, H, Riley, EM   +5 more
core   +4 more sources

Immunopathology of Acute Kidney Injury in Severe Malaria

Frontiers in Immunology, 2021
Acute kidney injury (AKI) is a common feature of severe malaria, and an independent risk factor for death. Previous research has suggested that an overactivation of the host inflammatory response is at least partly involved in mediating the kidney damage
Orestis Katsoulis, Athina Georgiadou, A. Cunnington   +2 more
semanticscholar   +1 more source

Improving the diagnosis of severe malaria in African children using platelet counts and plasma PfHRP2 concentrations

Science Translational Medicine, 2021
Severe malaria caused by Plasmodium falciparum is difficult to diagnose accurately in children in high-transmission settings. Using data from 2649 pediatric and adult patients enrolled in four studies of severe illness in three countries (Bangladesh ...
J. Watson, S. Uyoga, P. Wanjiku, J. Makale, G. Nyutu, N. Mturi, E. C. George, C. Woodrow, N. Day, P. Bejon, R. Opoka, A. Dondorp, C. John, K. Maitland, T. Williams, N. White   +15 more
semanticscholar   +1 more source

Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria [PDF]

, 2014
Systemic inflammation and sequestration of parasitized erythrocytes are central processes in the pathophysiology of severe Plasmodium falciparum childhood malaria. However, it is still not understood why some children are more at risks to develop malaria
Afolabi, Nathaniel K., Ajetunmobi, Wasiu A., Akinbami, Felix O., Akinkunmi, Francis, Bachmann, Julie, Brown, Biobele J., Burte, Florence, Conte, Ianina, Fernandez-Reyes, Delmiro, Kampf, Caroline, Nilsson, Peter, Omokhodion, Samuel, Orimadegun, Adebola E., Pawitan, Yudi, Pramana, Setia, Schwenk, Jochen M., Shokunbi, Wuraola A., Sodeinde, Olugbemiro, Uhlen, Mathias, Wahlgren, Mats   +19 more
core   +11 more sources

Malaria Related Neurocognitive Deficits and Behavioral Alterations

Frontiers in Cellular and Infection Microbiology, 2022
Typical of tropical and subtropical regions, malaria is caused by protozoa of the genus Plasmodium and is, still today, despite all efforts and advances in controlling the disease, a major issue of public health. Its clinical course can present either as
Pamela Rosa-Gonçalves, Pamela Rosa-Gonçalves, Pamela Rosa-Gonçalves, Flávia Lima Ribeiro-Gomes, Flávia Lima Ribeiro-Gomes, Cláudio Tadeu Daniel-Ribeiro, Cláudio Tadeu Daniel-Ribeiro   +6 more
doaj   +1 more source