Results 11 to 20 of about 235,333 (304)

Severe childhood malaria syndromes defined by plasma proteome profiles [PDF]

, 2012
BACKGROUND Cerebral malaria (CM) and severe malarial anemia (SMA) are the most serious life-threatening clinical syndromes of Plasmodium falciparum infection in childhood.
A Hodgetts, Adebola E. Orimadegun, AE Orimadegun, AK Rowe, AL Conroy, Barry K. Ely, Biobele J. Brown, C Wu, D Agranoff, Delmiro Fernandez-Reyes, Dimitrios Athanasakis, FE Lovegrove, Felix O. Akinbami, Florence Burté, Francesca Battaglia, Francis Akinkunmi, FX Wu, G Sandhu, J Amzat, J Bryce, K Marsh, Kevin KA. Tetteh, Kikelomo Osinusi, LK Erdman, MC Papadopoulos, Nathaniel K. Afolabi, Olayinka Kowobari, Olugbemiro Sodeinde, RT Pang, RW Snow, S Rojas-Galeano, Samuel Omokhodion, SI Hay, SI Hay, SJ Ceesay, Wasiu A. Ajetunmobi, Wuraola A. Shokunbi   +36 more
core   +6 more sources

BIOMARKERS AND PROGNOSTIC SCORING IN CEREBRAL MALARIA

Malang Neurology Journal, 2022
Malaria remains a public health concern and remain the deadliest in infectious disease in the world. Cerebral malaria is a particularly severe complication of this disease and associated with high mortality.
Orlando Pikatan, Ellen Ferlita Tirtana, Kezia Seraphine, Wienta Diarsvitri   +3 more
doaj   +1 more source

Malaria Hepatopathy and Thrombocytopenia in Severe Falciparum Malaria

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2023
Jaundice commonly occurs in severe malaria, seen in approximately 2,5% patients with falciparum malaria infection. Jaundice in malaria can be caused by intravascular hemolysis, disseminated intravascular coagulation (DIC) or malaria-related liver ...
Muhammad Vitanata Arfijanto, Mohammad Imam Wahyudi   +1 more
doaj   +1 more source

Associations between erythrocyte polymorphisms and risks of uncomplicated and severe malaria in Ugandan children: A case control study. [PDF]

PLoS ONE, 2018
BACKGROUND:Evidence for association between sickle cell and alpha thalassemia trait and severe malaria is compelling. However, for these polymorphisms associations with uncomplicated malaria, and for G6PD deficiency associations with uncomplicated and ...
Arthur Mpimbaza, Andrew Walakira, Grace Ndeezi, Anne Katahoire, Charles Karamagi, Samuel L Nsobya, Stephen Tukwasibwe, Victor Asua, Philip J Rosenthal   +8 more
doaj   +1 more source

Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria [PDF]

, 2014
Systemic inflammation and sequestration of parasitized erythrocytes are central processes in the pathophysiology of severe Plasmodium falciparum childhood malaria. However, it is still not understood why some children are more at risks to develop malaria
Afolabi, Nathaniel K., Ajetunmobi, Wasiu A., Akinbami, Felix O., Akinkunmi, Francis, Bachmann, Julie, Brown, Biobele J., Burte, Florence, Conte, Ianina, Fernandez-Reyes, Delmiro, Kampf, Caroline, Nilsson, Peter, Omokhodion, Samuel, Orimadegun, Adebola E., Pawitan, Yudi, Pramana, Setia, Schwenk, Jochen M., Shokunbi, Wuraola A., Sodeinde, Olugbemiro, Uhlen, Mathias, Wahlgren, Mats   +19 more
core   +3 more sources

Artemether for severe malaria [PDF]

Cochrane Database of Systematic Reviews, 2014
In 2011 the World Health Organization (WHO) recommended parenteral artesunate in preference to quinine as first-line treatment for people with severe malaria. Prior to this recommendation, many countries, particularly in Africa, had begun to use artemether, an alternative artemisinin derivative.
Esu, Ekpereonne, Effa, Emmanuel E, Opie, Oko N, Uwaoma, Amirahobu, Meremikwu, Martin M   +4 more
openaire   +2 more sources

Preclinical immunogenicity and safety of the cGMP-grade placental malaria vaccine PRIMVACResearch in context

EBioMedicine, 2019
Background: VAR2CSA is the lead antigen for developing a vaccine that would protect pregnant women against placental malaria. A multi-system feasibility study has identified E.
Arnaud Chêne, Stéphane Gangnard, Anna Guadall, Hervé Ginisty, Odile Leroy, Nicolas Havelange, Nicola K. Viebig, Benoît Gamain   +7 more
doaj   +1 more source

Assessment of severe malaria in a multicenter, phase III, RTS, S/AS01 malaria candidate vaccine trial: case definition, standardization of data collection and patient care. [PDF]

, 2011
BACKGROUND\ud \ud An effective malaria vaccine, deployed in conjunction with other malaria interventions, is likely to substantially reduce the malaria burden. Efficacy against severe malaria will be a key driver for decisions on implementation.
Amanda Leach, Brian Greenwood, Daniel Ansong, David Schellenberg, Jahit Sacarlal, Jennifer Evans, Johan Vekemans, Kevin Marsh, Kwaku Asante, Mary J Hamel, Nahya Salim, null null, Patricia Njuguna, Philip Bejon, Portia Kamthunzi, Samwel Gesase, Solange Soulanoudjingar, Walter Otieno, William Kabore   +18 more
core   +4 more sources

Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision

eLife, 2021
Severe falciparum malaria has substantially affected human evolution. Genetic association studies of patients with clinically defined severe malaria and matched population controls have helped characterise human genetic susceptibility to severe malaria ...
James A Watson, Carolyne M Ndila, Sophie Uyoga, Alexander Macharia, Gideon Nyutu, Shebe Mohammed, Caroline Ngetsa, Neema Mturi, Norbert Peshu, Benjamin Tsofa, Kirk Rockett, Stije Leopold, Hugh Kingston, Elizabeth C George, Kathryn Maitland, Nicholas PJ Day, Arjen M Dondorp, Philip Bejon, Thomas N Williams, Chris C Holmes, Nicholas J White   +20 more
doaj   +1 more source

Malaria-filaria coinfection in mice makes malarial disease more severe unless filarial infection achieves patency [PDF]

, 2005
Coinfections are common in natural populations, and the literature suggests that helminth coinfection readily affects how the immune system manages malaria.
Allen, Judith E, Graham, Andrea L, Lamb, Tracey J, Read, Andrew F   +3 more
core   +3 more sources