Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study [PDF]
, 2018 Background: Human genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms—many related to the structure or function of red blood cells—and risk for severe Plasmodium falciparum ...
Alexander, W Macharia +28 more
core +1 more source
Associations between erythrocyte polymorphisms and risks of uncomplicated and severe malaria in Ugandan children: A case control study. [PDF]
PLoS ONE, 2018 BACKGROUND:Evidence for association between sickle cell and alpha thalassemia trait and severe malaria is compelling. However, for these polymorphisms associations with uncomplicated malaria, and for G6PD deficiency associations with uncomplicated and ...
Arthur Mpimbaza +8 more
doaj +1 more source
Assessment of severe malaria in a multicenter, phase III, RTS, S/AS01 malaria candidate vaccine trial: case definition, standardization of data collection and patient care. [PDF]
, 2011 BACKGROUND\ud \ud An effective malaria vaccine, deployed in conjunction with other malaria interventions, is likely to substantially reduce the malaria burden. Efficacy against severe malaria will be a key driver for decisions on implementation.
Amanda Leach +18 more
core +4 more sources
A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria [PDF]
, 2004 Parasitized red blood cells (RBCs) from children suffering from severe malaria often adhere to complement receptor 1 (CR1) on uninfected RBCs to form clumps of cells known as "rosettes." Despite a well documented association between rosetting and severe ...
A. O'Donnell +49 more
core +1 more source
The treatment of severe falciparum malaria. [PDF]
BMJ, 1977 In severe falciparum malaria there is a pathophysiological cascade beginning with changes in the parasitized red blood cells which induce intermediate effects, in turn contributing to dysfunction of several organs. A low serum albumin is a common but often unrecognized finding which may contribute to oedema especially in the lung and brain.
W, Peters, A P, Hall
openaire +5 more sources
Increased interferon-γ levels and risk of severe malaria: a meta-analysis
Scientific Reports, 2022 Interferon (IFN)-γ contributes to the pathogenesis of severe malaria; however, its mechanism remains unclear. Herein, differences in IFN-γ levels between patients with severe and uncomplicated malaria were evaluated using qualitative and quantitative ...
Aongart Mahittikorn +5 more
doaj +1 more source
Infectious Diseases and Herbal Medicine, 2021 Studies assessing the immunoglobulin G (IgG) antibody responses in severe malaria are not readily available. This study was designed to compare the IgG and IgG1-4 antibody responses in severe malaria and its major clinical presentations (cerebral ...
Tebit Emmanuel Kwenti +5 more
doaj +1 more source
Diagnosing Severe Falciparum Malaria in Parasitaemic African Children: A Prospective Evaluation of Plasma PfHRP2 Measurement. [PDF]
, 2012 In African children, distinguishing severe falciparum malaria from other severe febrile illnesses with coincidental Plasmodium falciparum parasitaemia is a major challenge. P. falciparum histidine-rich protein 2 (PfHRP2) is released by mature sequestered
Amos, Ben +23 more
core +5 more sources
Severe vivax malaria in Eastern India
Asian Journal of Medical Sciences, 2015 Background: Conventionally, vivax malaria was called as benign malaria. But recent reports of severe vivax malaria were coming from different parts of the World.
Joydeep Mukherjee
doaj +1 more source
Malaria infection and severe disease risks in Africa
Science, 2021 Childhood malaria Understanding how changes in community parasite prevalence alter the rate and age distribution of severe malaria is essential for optimizing control efforts. Paton et al.
Robert S Paton +18 more
semanticscholar +1 more source