Results 51 to 60 of about 235,333 (304)
Relation between Increased IL-10 Levels and Malaria Severity: A Systematic Review and Meta-Analysis
Tropical Medicine and Infectious Disease, 2023 The roles of anti-inflammatory cytokines in the pathogenesis of severe malaria have been widely studied, and the role of IL-10 in the pathogenesis of severe malaria remains unclear.
Phoomjai Sornsenee +5 more
doaj +1 more source
, 2005 Artemisinins were discovered to be highly effective antimalarial drugs shortly after the isolation of the parent artemisinin in 1971 in China. These compounds combine potent, rapid antimalarial activity with a wide therapeutic index and an absence of ...
Haynes, RK, Krishna, S, Woodrow, CJ
core +3 more sources
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Advocating an attack against severe malaria: a cost-effectiveness analysis
BMC Public Health, 2020 Background A recent study found that the gut microbiota, Lactobacillus and Bifidobacterium, have the ability to modulate the severity of malaria. The modulation of the severity of malaria is not however, the typical focal point of most widespread ...
Scott Greenhalgh, Veda Chandwani
doaj +1 more source
an 8-year multi-centre observational study [PDF]
, 2017 Background Malaria remains one of the most serious infections for travellers to tropical countries. Due to the lack of harmonized guidelines a large variety of treatment regimens is used in Europe to treat severe malaria. Methods The European Network for
Antinori, Spinello +6 more
core +1 more source
Advanced Science, EarlyView.NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou +9 more
wiley +1 more source
Assessment of perinatal outcomes of pregnant women with severe versus simple malaria.
PLoS ONE, 2021 ObjectiveMalaria in pregnancy is associated with adverse perinatal outcomes. The objective was to compare outcomes of simple and severe malaria and to determine whether they vary by trimester or severity of infection.MethodsProspective cohort study ...
Alfred Kwizera +5 more
doaj +1 more source
Changing pattern of malaria in Bissau, Guinea Bissau.
, 2008 OBJECTIVE: To describe the epidemiology of malaria in Guinea-Bissau, in view of the fact that more funds are available now for malaria control in the country.
Aaby, Peter +4 more
core +1 more source
Quantitative trait locus analysis of parasite density reveals that HbS gene carriage protects severe malaria patients against Plasmodium falciparum hyperparasitaemia [PDF]
, 2015 This deposit is composed by the main article, and it hasn't any supplementary materials associated.Haemoglobin S (HbS) is the gene known to confer the strongest advantage against malaria morbidity and mortality.
Costa, João +5 more
core +2 more sources
Molecular basis of severe malaria [PDF]
Proceedings of the National Academy of Sciences, 2012 Malaria is an ancient scourge that continues to plague many regions of the developing world. Despite its long history, many aspects of the disease remain difficult to explain. For example, why some individuals experience relatively mild symptoms and others progress to severe and sometimes lethal disease is not understood. Similarly, the molecular basis
Kirk W, Deitsch, Chetan E, Chitnis
openaire +2 more sources