Results 51 to 60 of about 3,150,561 (392)

Severe malaria in children leads to a significant impairment of transitory otoacoustic emissions--a prospective multicenter cohort study. [PDF]

, 2015
BACKGROUND: Severe malaria may influence inner ear function, although this possibility has not been examined prospectively. In a retrospective analysis, hearing impairment was found in 9 of 23 patients with cerebral malaria.
A Freeland, A Sowunmi, Allan Otieno, Ayola A. Adegnika, B Engdahl, Benjamin Mordmüller, Bernards Ogutu, CR Newton, D Tucci, Daniel Ansong, DH Lee, DK Mukherjee, Erich Schmutzhard, FA Claessen, Fabian Cedric Aregger, GO Adjei, Helene Verena Hurth, J Schmutzhard, J Schmutzhard, J Schmutzhard, J Schmutzhard, J Vekemans, JA Carter, Joachim Schmutzhard, Josua Kegele, L Yin, Leyla Pinggera, Lukas Oberhammer, M Wise, MJ Manary, MJ Potchen, Natalie Fischer, Patrick Zorowka, Peter Kremsner, Peter Lackner, Q Gopen, R Helbok, R Hutagalung, R Idro, Raimund Helbok, S Toovey, Saadou Issifou, Sanjeev Krishna, Sebastian Bunk, SZ Zhao, T Janssen, T Rolling, T Taylor, TG Brewer, Tsiri Agbenyega, U Proschel, V Ramos-Martin, Veronika Muigg, WE Brownell   +53 more
core   +1 more source

The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen–encoding var genes

PLoS Biology, 2018
Within the human host, the malaria parasite Plasmodium falciparum is exposed to multiple selection pressures. The host environment changes dramatically in severe malaria, but the extent to which the parasite responds to—or is selected by—this environment
G. Tonkin-Hill, Leily Trianty, Rintis Noviyanti, Hanh H. T. Nguyen, Boni F. Sebayang, Daniel A. Lampah, J. Marfurt, Simon A. Cobbold, Janavi S. Rambhatla, M. McConville, S. Rogerson, Graham V. Brown, K. Day, R. Price, N. Anstey, A. Papenfuss, M. Duffy   +16 more
semanticscholar   +1 more source

Gametocyte carriage in Plasmodium falciparum-infected travellers. [PDF]

, 2013
BACKGROUND: Gametocytes are the sexual stage of Plasmodium parasites. The determinants of gametocyte carriage have been studied extensively in endemic areas, but have rarely been explored in travellers with malaria.
Armstrong, Margaret, Boadi, Samuel, Chiodini, Peter L, Doherty, Tom, Roberts, Catherine H, Sutherland, Colin J, Warren, Simon, Zatyka, Ewa   +7 more
core   +3 more sources

Adjunctive therapy for severe malaria: a review and critical appraisal

Malaria Journal, 2018
Despite recent efforts and successes in reducing the malaria burden globally, this infection still accounts for an estimated 212 million clinical cases, 2 million severe malaria cases, and approximately 429,000 deaths annually.
Rosauro Varo, V. Crowley, António Sitoe, L. Madrid, L. Serghides, K. Kain, Q. Bassat   +6 more
semanticscholar   +1 more source

Plasmodium falciparum infection patterns since birth and risk of severe malaria: a nested case-control study in children on the coast of Kenya. [PDF]

PLoS ONE, 2013
Children in malaria endemic areas acquire immunity to severe malaria faster than to mild malaria. Only a minority of children suffers from severe malaria and it is not known what determines this. The aim of this study was to establish how P.
Klara Lundblom, Linda Murungi, Victoria Nyaga, Daniel Olsson, Josea Rono, Faith Osier, Edna Ogada, Scott Montgomery, J Anthony G Scott, Kevin Marsh, Anna Färnert   +10 more
doaj   +1 more source

Relation between Increased IL-10 Levels and Malaria Severity: A Systematic Review and Meta-Analysis

Tropical Medicine and Infectious Disease, 2023
The roles of anti-inflammatory cytokines in the pathogenesis of severe malaria have been widely studied, and the role of IL-10 in the pathogenesis of severe malaria remains unclear.
Phoomjai Sornsenee, Polrat Wilairatana, Kwuntida Uthaisar Kotepui, Frederick Ramirez Masangkay, Chonticha Romyasamit, Manas Kotepui   +5 more
doaj   +1 more source

Observational study: 27 years of severe malaria surveillance in Kilifi, Kenya

BMC Medicine, 2019
BackgroundMany parts of Africa have witnessed reductions in Plasmodium falciparum transmission over the last 15 years. Since immunity to malaria is acquired more rapidly at higher transmission, the slower acquisition of immunity at lower transmission may
P. Njuguna, K. Maitland, A. Nyaguara, Daniel Mwanga, Polycarp Mogeni, N. Mturi, Shebe Mohammed, G. Mwambingu, Caroline J Ngetsa, Ken O. Awuondo, B. Lowe, I. Adetifa, J. A. Scott, Tom Williams, S. Atkinson, F. Osier, Robert W. Snow, K. Marsh, B. Tsofa, N. Peshu, M. Hamaluba, J. A. Berkley, Charles R. Newton, J. Fondo, A. Omar, P. Bejon   +25 more
semanticscholar   +1 more source

A HOSPITAL-BASED RETROSPECTIVE COMPARATIVE STUDY OF COMPLICATIONS, OUTCOMES, CLINICAL AND LABORATORY PARAMETERS OF MALARIA WITH AND WITHOUT NEUROLOGICAL INVOLVEMENT

Mediterranean Journal of Hematology and Infectious Diseases, 2017
Background & Objectives: Classically associated with Plasmodium falciparum, neurological complications in severe malaria is associated with increased morbidity and mortality.
Sohaib Ahmad, Nadia Shirazi, Nowneet Kumar Bhat, Minakshi Dhar, Garima Mittal, Manish Mittal, Nidhi Kaeley, Manoj Kumar   +7 more
doaj   +1 more source

Effectiveness of Seasonal Malaria Chemoprevention in children under 10 years of age in Senegal: a stepped-wedge cluster-randomized trial [PDF]

, 2016
This study was done to determine the effectiveness of Seasonal Malaria Chemoprevention in Senegalese children up to 10 years of age using a stepped-wedge design.
Milligan, Paul
core   +2 more sources

What causes severe malaria and its complications in children? Lessons learned over the past 15 years

BMC Medicine, 2019
Over the past 15 years, malaria mortality has reduced by approximately 50%. However, malaria still causes more than 400,000 deaths annually, most of which occur in African children under 5 years of age.
A. Conroy, D. Datta, C. John
semanticscholar   +1 more source