Results 81 to 90 of about 235,333 (304)

Endothelial protein C receptor gene variants not associated with severe malaria in ghanaian children. [PDF]

PLoS ONE, 2014
BACKGROUND: Two recent reports have identified the Endothelial Protein C Receptor (EPCR) as a key molecule implicated in severe malaria pathology. First, it was shown that EPCR in the human microvasculature mediates sequestration of Plasmodium falciparum-
Kathrin Schuldt, Christa Ehmen, Jennifer Evans, Juergen May, Daniel Ansong, Juergen Sievertsen, Birgit Muntau, Gerd Ruge, Tsiri Agbenyega, Rolf D Horstmann   +9 more
doaj   +1 more source

Delayed haemolysis after artesunate therapy in a cohort of patients with severe imported malaria due to Plasmodium falciparum [PDF]

, 2016
INTRODUCTION: Delayed haemolytic anaemia is one of the more frequent events after treatment with intravenous artesunate in patients with severe malaria.
Calvo-Cano, Antonia, Gascón i Brustenga, Joaquim, Gómez Junyent, Joan, Muñoz, José, Ruiz-Panales, Pedro   +4 more
core   +1 more source

Discovery of an Atypical Arp2/3 Complex in Malaria Parasites Sheds New Light on Nuclear Actin

Cytoskeleton, EarlyView.
ABSTRACT The Arp2/3 complex is a key actin nucleator essential for cytoskeletal dynamics in eukaryotes. Previously believed absent in apicomplexan parasites, we recently identified an atypical Arp2/3 complex in malaria parasites consisting of five divergent subunits and a putative kinetochore‐associated factor.
Franziska Hentzschel, Friedrich Frischknecht, Matthias Marti   +2 more
wiley   +1 more source

Endothelial transcriptomic analysis identifies biomarkers of severe and cerebral malaria

JCI Insight, 2023
Malaria can quickly progress from an uncomplicated infection into a life-threatening severe disease. However, the unspecificity of early symptoms often makes it difficult to identify patients at high risk of developing severe disease.
Cláudia Gomes, Rosauro Varo, Miquel Duran-Frigola, Antonio Sitoe, Rubão Bila, Sonia Machevo, Alfredo Mayor, Quique Bassat, Ana Rodriguez   +8 more
doaj   +1 more source

Anti-malarial prescription practices among outpatients with laboratory-confirmed malaria in the setting of a health facility-based sentinel site surveillance system in Uganda. [PDF]

, 2013
BACKGROUND: Most African countries have adopted artemisinin-based combination therapy (ACT) as the first-line treatment for uncomplicated malaria. The World Health Organization now recommends limiting anti-malarial treatment to those with a positive ...
Chang, Michelle, Dorsey, Grant, Kakeeto, Stella, Kamya, Moses R, Kapella, Bryan K, Kigozi, Ruth, Mpimbaza, Arthur, Rubahika, Denis, Sears, David, Sserwanga, Asadu, Staedke, Sarah G   +10 more
core   +3 more sources

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Carriage of chloroquine-resistant parasites and delay of effective treatment increase the risk of severe malaria in Gambian children.

, 2005
Two hundred thirty-four Gambian children with severe falciparum malaria who were admitted to the pediatric ward of a rural district hospital each were matched for age with a same-sex control subject presenting as an outpatient with uncomplicated ...
Bousema, J Teun, Hallett, Rachel, Meerman, Larissa, Ord, Rosalynn, Osman, Emilia, Pinder, Margaret, Sutherland, Colin J, van Niekerk, Maarten, Walraven, Gijs   +8 more
core   +1 more source

The role of red blood cell exchange for severe imported malaria in the artesunate era: a retrospective cohort study in a referral centre [PDF]

, 2016
BACKGROUND: Intravenous artesunate has replaced quinine as the first-line therapy for severe imported malaria, given its anti-malarial superiority shown in clinical trials conducted in endemic countries.
Calvo-Cano, Antonia, Castro, Pedro, Cid Vidal, Joan, Gascón i Brustenga, Joaquim, Gómez Junyent, Joan, Lozano Molero, Miguel, Martin, Maite, Muñoz, José, Nicolás Arfelis, Josep Maria, Quintó, Llorenç   +9 more
core   +1 more source

Intraleucocytic malaria pigment and prognosis in severe malaria

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1995
The quantity of malaria pigment liberated into the circulation at schizogony reflects the pathogenic sequestered parasite burden in Plasmodium falciparum malaria, and may therefore be a measure of disease severity. Among 300 consecutive adult patients with severe falciparum malaria, the 40 who died had significantly higher proportions of malaria ...
Nguyen, P, Day, N, Pram, T, Ferguson, D, White, N   +4 more
openaire   +2 more sources

Acidosis in severe childhood malaria [PDF]

QJM, 1997
Data were prospectively collected on 306 Kenyan children, including blood gases in 258 (75%). Severe malaria caused a predominantly high-anion-gap metabolic acidosis in at least 43% of children. Children with coma and respiratory distress (CM + RD) had greater evidence of renal dysfunction, lower mean pH and higher mean plasma osmolality than those ...
English, M., Sauerwein, R.W., Waruiru, C., Mosobo, M., Obiero, J., Lowe, B., Marsh, K.   +6 more
openaire   +5 more sources