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Engineering fungal de novo fatty acid synthesis for short chain fatty acid production [PDF]

open access: yesNature Communications, 2017
The production of short chain fatty acids by microorganisms has numerous industrial and biofuel applications. Here the authors reprogrammeS. cerevisiaefatty acid synthase with five mutations to produce C6- and C8-fatty acids and identify thioesterases ...
Jan Gajewski   +4 more
doaj   +5 more sources

The mechanism of short-chain fatty acid in hypertriglyceridemic pancreatitis [PDF]

open access: yesFrontiers in Microbiology
IntroductionThe incidence of hypertriglyceridemia pancreatitis (HTGP) has been rising annually with a poor prognosis, and its pathogenesis is complex. In recent years, the role of gut microbiota and short-chain fatty acids (SCFAs) has gradually attracted
Tingting Li   +10 more
doaj   +2 more sources

Short-Chain Fatty Acid Utilization in Cyberlindnera jadinii for Single-Cell Protein and Odd-Chain Fatty Acid Production [PDF]

open access: yesMicroorganisms
In view of the growing global need for sustainable protein sources, this study explores the utilization of short-chain fatty acids into single-cell protein using the non-conventional yeast Cyberlindnera jadinii. Short-chain fatty acids can be sustainably
Christian Hermansen   +7 more
doaj   +2 more sources

Effect of Season on Fatty Acid Content of Holstein Cow Milk in Inner Mongolia [PDF]

open access: yesShipin Kexue, 2023
In order to evaluate the influence of season on the fatty acid content of Holstein cow milk in Inner Mongolia, milk samples were collected from 10 large commercial pastures in Inner Mongolia during four seasons (spring, summer, autumn and winter) and ...
LIANG Jianying, TANG Shuo, ZHANG Zhiwei, DUAN Guoxia, LIU Chunxia, GONG Huili, HU Wenhui
doaj   +1 more source

Short-chain fatty acids activate acetyltransferase p300 [PDF]

open access: yeseLife, 2021
Abstract Short-chain fatty acids (SCFAs) acetate, propionate, and butyrate are produced in large quantities by the gut microbiome and contribute to a wide array of physiological processes. While the underlying mechanisms are largely unknown, many effects of SCFAs have been traced to changes in the cell’s epigenetic state.
Sydney P Thomas, John M Denu
openaire   +3 more sources

Acetate suppresses myocardial contraction via the short-chain fatty acid receptor GPR43

open access: yesFrontiers in Physiology, 2022
The heart has high energy requirements, with an estimated 40%–60% of myocardial ATP production derived from the oxidation of fatty acids under physiological conditions.
Xuan Jiang   +10 more
doaj   +1 more source

Medium-chain fatty acids enhance expression and histone acetylation of genes related to lipid metabolism in insulin-resistant adipocytes

open access: yesBiochemistry and Biophysics Reports, 2022
Background: The expressions of genes related to lipid metabolism are decreased in adipocytes with insulin resistance. In this study, we examined the effects of fatty acids on the reduced expressions and histone acetylation of lipid metabolism-related ...
Musashi Kawamura   +6 more
doaj   +1 more source

Research Progress on the Functions of Short Chain Fatty Acid [PDF]

open access: yesShipin Kexue, 2023
Short chain fatty acid (SCFA), a class of fatty acids with six or less carbon atoms, have important physiological functions for human health. As metabolites of the intestinal flora, SCFA can maintain intestinal health.
YANG Xue, GAO Yanan, WANG Jiaqi, ZHENG Nan
doaj   +1 more source

Ir56d-dependent fatty acid responses in Drosophila uncover taste discrimination between different classes of fatty acids

open access: yeseLife, 2021
Chemosensory systems are critical for evaluating the caloric value and potential toxicity of food. While animals can discriminate between thousands of odors, much less is known about the discriminative capabilities of taste systems.
Elizabeth B Brown   +5 more
doaj   +1 more source

Short-chain fatty acids directly exert anti-inflammatory responses in podocytes and tubular epithelial cells exposed to high glucose

open access: yesFrontiers in Cell and Developmental Biology, 2023
Aims: Gut-microbiome derived short-chain fatty acids exert anti-inflammatory effects and delay progression of kidney disease in diabetic nephropathy. The aim of this study was to examine the impact in vivo and in vitro of short-chain fatty acid treatment
Yan Jun Li   +9 more
doaj   +1 more source

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