Results 21 to 30 of about 197,415 (263)

Short-chain fatty acids in cancer pathogenesis

Cancer and Metastasis Reviews, 2023
AbstractCancer is a multi-step process that can be viewed as a cellular and immunological shift away from homeostasis in response to selected infectious agents, mutations, diet, and environmental carcinogens. Homeostasis, which contributes importantly to the definition of “health,” is maintained, in part by the production of short-chain fatty acids ...
Mark A. Feitelson, Alla Arzumanyan, Arvin Medhat, Ira Spector   +3 more
openaire   +2 more sources

Short chain fatty acids: the messengers from down below

Frontiers in Neuroscience, 2023
Short-chain fatty acids (SCFAs), produced by the metabolism of dietary fibers in the gut, have wide-ranging effects locally and throughout the body. They modulate the enteric and central nervous systems, benefit anti-inflammatory pathways, and serve as ...
Virginie Mansuy-Aubert, Yann Ravussin
doaj   +1 more source

Medium-chain fatty acids enhance expression and histone acetylation of genes related to lipid metabolism in insulin-resistant adipocytes

Biochemistry and Biophysics Reports, 2022
Background: The expressions of genes related to lipid metabolism are decreased in adipocytes with insulin resistance. In this study, we examined the effects of fatty acids on the reduced expressions and histone acetylation of lipid metabolism-related ...
Musashi Kawamura, Naoki Goda, Natsuyo Hariya, Mayu Kimura, Shiori Ishiyama, Takeo Kubota, Kazuki Mochizuki   +6 more
doaj   +1 more source

Regulation of short-chain fatty acid production [PDF]

Proceedings of the Nutrition Society, 2003
Short-chain fatty acid (SCFA) formation by intestinal bacteria is regulated by many different host, environmental, dietary and microbiological factors. In broad terms, however, substrate availability, bacterial species composition of the microbiota and intestinal transit time largely determine the amounts and types of SCFA that are produced in healthy ...
Sandra, Macfarlane, George T, Macfarlane
openaire   +2 more sources

Cerebral gustatory activation in response to free fatty acids using gustatory evoked potentials in humans

Journal of Lipid Research, 2019
There is some evidence of specific oro-detection of FFAs in rodents and humans. The aim of this study was to record gustatory evoked potentials (GEPs) in response to FFA solutions and to compare GEPs in response to linoleic acid solution with GEPs ...
Thomas Mouillot, Emilie Szleper, Gaspard Vagne, Sophie Barthet, Djihed Litime, Marie-Claude Brindisi, Corinne Leloup, Luc Penicaud, Sophie Nicklaus, Laurent Brondel, Agnès Jacquin-Piques   +10 more
doaj   +1 more source

Development of gut microbiota along with its metabolites of preschool children

BMC Pediatrics, 2022
Background To reveal the changes of intestinal microbial abundance and composition, as well as the microbiota metabolic levels of bile acids and short chain fatty acids of healthy preschool children during their growth.
Jingjing Xiong, Hongwei Hu, Chuanzhi Xu, Jianwen Yin, Mei Liu, Lizhi Zhang, Yong Duan, Yongkun Huang   +7 more
doaj   +1 more source

Short- and medium-chain fatty acids in energy metabolism: the cellular perspective

Journal of Lipid Research, 2016
Short- and medium-chain fatty acids (SCFAs and MCFAs), independently of their cellular signaling functions, are important substrates of the energy metabolism and anabolic processes in mammals.
Peter Schönfeld, Lech Wojtczak
doaj   +1 more source

Absorption of Short-Chain Fatty Acids by the Colon

Gastroenterology, 1980
Short-chain fatty acids (SCFAs) constitute the major solute fraction of normal stool water and are responsible for the diarrhea associated with carbohydrate (CHO) malabsorption. Although SCFA absorption from the human small bowel has been reported previously, the fate of SCFAs in the colon--their major site of production--was investigated in the ...
H, Ruppin, S, Bar-Meir, K H, Soergel, C M, Wood, M G, Schmitt   +4 more
openaire   +2 more sources

Short-chain fatty acids mediate enteric and central nervous system homeostasis in Parkinson’s disease: Innovative therapies and their translation

Neural Regeneration Research
Short-chain fatty acids, metabolites produced by the fermentation of dietary fiber by gut microbiota, have garnered significant attention due to their correlation with neurodegenerative diseases, particularly Parkinson’s disease.
Shimin Pang, Zhili Ren, Hui Ding, Piu Chan   +3 more
doaj   +1 more source

The Pharmacology and Function of Receptors for Short-Chain Fatty Acids [PDF]

Molecular Pharmacology, 2016
Despite some blockbuster G protein-coupled receptor (GPCR) drugs, only a small fraction (∼ 15%) of the more than 390 nonodorant GPCRs have been successfully targeted by the pharmaceutical industry. One way that this issue might be addressed is via translation of recent deorphanization programs that have opened the prospect of extending the reach of new
Bolognini, Daniele, Tobin, Andrew B., Milligan, Graeme, Moss, Catherine E.   +3 more
openaire   +3 more sources