Results 61 to 70 of about 4,489 (227)

A simple methodology to assess endolysosomal protease activity involved in antigen processing in human primary cells [PDF]

, 2013
Background: Endolysosomes play a key role in maintaining the homeostasis of the cell. They are made of a complex set of proteins that degrade lipids, proteins and sugars. Studies involving endolysosome contribution to cellular functions such as MHC class
Boucau, Julie, Duong, Ellen, Gandhi, Malini, Lai, Nicole Y, Le Gall, Sylvie, Shimada, Mariko, Vaithilingam, Archana, Xu, Yang   +7 more
core   +1 more source

Unveiling VCAM‐1’s Multifaceted Role in Secondary Diabetic Complications

Journal of Food Quality, Volume 2025, Issue 1, 2025.
Diabetes mellitus is a chronic metabolic disorder characterized by sustained hyperglycemia, tightly interlinked with a range of severe secondary complications. Diabetic retinopathy, nephropathy, and cardiomyopathy substantially contribute to the overall morbidity and mortality associated with diabetes.
Prabhnain Kaur, Ritu, Kalicharan Sharma, Ramesh K. Goyal, Parakh Basist, Rahmuddin Khan, Abdulsalam Alhalmi, Mohamed Addi   +7 more
wiley   +1 more source

Persistent reduction in sialylation of cerebral glycoproteins following postnatal inflammatory exposure

Journal of Neuroinflammation, 2018
Background The extension of sepsis encompassing the preterm newborn’s brain is often overlooked due to technical challenges in this highly vulnerable population, yet it leads to substantial long-term neurodevelopmental disabilities.
Ekaterina P. Demina, Wyston C. Pierre, Annie L. A. Nguyen, Irene Londono, Bela Reiz, Chunxia Zou, Radhika Chakraberty, Christopher W. Cairo, Alexey V. Pshezhetsky, Gregory A. Lodygensky   +9 more
doaj   +1 more source

Genomic, Proteomic, and Phenotypic Spectrum of Novel O-Sialoglycoprotein Endopeptidase Variant in Four Affected Individuals With Galloway-Mowat Syndrome [PDF]

, 2022
Malak Alghamdi, Hicham Benabdelkamel, Afshan Masood, Narjes Saheb Sharif‐Askari, Mahmood Yaseen Hachim, Hamad Alsheikh, Muddathir H. Hamad, Mustafa A. Salih, Fahad A. Bashiri, Khalid Alhasan, Tarek Kashour, Pilar Guatibonza Moreno, Sabine Schröder, Vasiliki Karageorgou, Aida M. Bertoli‐Avella, Hisham Alkhalidi, Dima Z. Jamjoom, Ibrahim A. Alorainy, Assim A. Alfadda, Rabih Halwani   +19 more
openalex   +1 more source

Overcoming the Blood–Brain Barrier: Multifunctional Nanomaterial‐Based Strategies for Targeted Drug Delivery in Neurological Disorders

Small Science, Volume 4, Issue 12, December 2024.
This review explores the diverse range of nanomaterials, including polymer, lipid, gold, magnetic, and carbon‐based nanostructures, capable of effectively passing the blood–brain barrier (BBB). Moreover, the structure and function of the BBB in both healthy and diseased states are discussed and the potential of nanotechnology in bypassing the BBB to ...
Callan D. McLoughlin, Sarah Nevins, Joshua B. Stein, Mehrdad Khakbiz, Ki‐Bum Lee   +4 more
wiley   +1 more source

The Role of Sialic Acid-Binding Receptors (Siglecs) in the Immunomodulatory Effects of Trypanosoma cruzi Sialoglycoproteins on the Protective Immunity of the Host

Scientifica, 2013
Chagas disease is caused by the protozoan parasite Trypanosoma cruzi and is an important endemic infection in Latin America. Lately, it has also become a health concern in the United States and Europe.
Alexandre Morrot
doaj   +1 more source

Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products.

PLoS ONE, 2009
BackgroundHumans are genetically defective in synthesizing the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc), but can metabolically incorporate it from dietary sources (particularly red meat and milk) into glycoproteins and glycolipids ...
Sandra L Diaz, Vered Padler-Karavani, Darius Ghaderi, Nancy Hurtado-Ziola, Hai Yu, Xi Chen, Els C M Brinkman-Van der Linden, Ajit Varki, Nissi M Varki   +8 more
doaj   +1 more source

Fucosylation of LAMP-1 and LAMP-2 by FUT1 correlates with lysosomal positioning and autophagic flux of breast cancer cells. [PDF]

, 2016
Alpha1,2-fucosyltransferases, FUT1 and FUT2, which transfer fucoses onto the terminal galactose of N-acetyl-lactosamine via α1,2-linkage have been shown to be highly expressed in various types of cancers.
Cho, Huan-Chieh, Ho, Ming-Yi, Hung, Jung-Tung, Tan, Keng-Poo, Yu, Alice Lin-Tsing, Yu, John   +5 more
core  

Lysosomal membrane permeabilization is an early event in sigma-2 receptor ligand mediated cell death in pancreatic cancer [PDF]

, 2012
BACKGROUND: Sigma-2 receptor ligands have been studied for treatment of pancreatic cancer because they are preferentially internalized by proliferating cells and induce apoptosis.
Abate, Carmen, Berardi, Francesco, Goedegebuure, Peter, Hawkins, William G, Hornick, John R, Mach, Robert H, Spitzer, Dirk, Vangveravong, Suwanna   +7 more
core   +2 more sources

Neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of Trem2 sialylation

Cell Reports
Summary: Neuraminidase 1 (NEU1) cleaves terminal sialic acids from sialoglycoproteins in endolysosomes and at the plasma membrane. As such, NEU1 regulates immune cells, primarily those of the monocytic lineage.
Leigh Ellen Fremuth, Huimin Hu, Diantha van de Vlekkert, Ida Annunziata, Jason Andrew Weesner, Alessandra d’Azzo   +5 more
doaj   +1 more source