Results 61 to 70 of about 4,387 (243)
Molecular Oncology, Volume 19, Issue 3, Page 635-658, March 2025.Screening colorectal tumors for glycoproteins linked to disease progression has revealed several potential therapeutic targets. The secretin receptor (SCTR), identified as a marker of poor prognosis and metastasis in colorectal cancer, has been shown to be a key carrier of N‐glycans with sialylated Lewis antigens. These cancer‐specific glycoproteoforms
Sofia Cotton +12 more
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Glyco-biomarkers: Potential determinants of cellular physiology and pathology [PDF]
, 2008 Once dismissed as just the icing on the cake, sugar molecules are emerging as vital components in life’s intricate machinery. Our understanding of their function within the context of the proteins and lipids to which they are attached has matured rapidly,
Alavi, A, Axford, JS
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Know Your ABCs: Discovery, Differentiation, and Targeting of T‐Bet+ B Cells
Immunological Reviews, Volume 330, Issue 1, March 2025.ABSTRACT Since their first description in 2008, T‐bet+ B cells have emerged as a clinically important B cell subset. Now commonly known as ABCs (Age‐associated B Cells), they are uniquely characterized by their expression of the transcription factor T‐bet. Indeed, this singular factor defines this B cell subset.
Gary M. Winslow, Russell Levack
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, 2023 Journal of Cosmetic Dermatology, Volume 22, Issue 12, Page 3195-3196, December 2023.
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Human thymic epithelial cells express an endogenous lectin, galectin-1, which binds to core 2 O-glycans on thymocytes and T lymphoblastoid cells. [PDF]
, 1995 Thymic epithelial cells play a crucial role in the selection of developing thymocytes. Thymocyte-epithelial cell interactions involve a number of adhesion molecules, including members of the integrin and immunoglobulin superfamilies.
Baum, LG +7 more
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Small Science, Volume 4, Issue 12, December 2024.This review explores the diverse range of nanomaterials, including polymer, lipid, gold, magnetic, and carbon‐based nanostructures, capable of effectively passing the blood–brain barrier (BBB). Moreover, the structure and function of the BBB in both healthy and diseased states are discussed and the potential of nanotechnology in bypassing the BBB to ...
Callan D. McLoughlin +4 more
wiley +1 more source
Journal of Neuroinflammation, 2018 Background The extension of sepsis encompassing the preterm newborn’s brain is often overlooked due to technical challenges in this highly vulnerable population, yet it leads to substantial long-term neurodevelopmental disabilities.
Ekaterina P. Demina +9 more
doaj +1 more source
Sialoglycoproteins of ejaculated human spermatozoa and seminal plasma [PDF]
International Journal of Andrology, 1984 Ejaculated human sperm were found to possess three major sialoglycoproteins with molecular weights of 30 000, 14 000 and 12 000 and one minor species of 18 000. Liquefied seminal plasma from normal donors contain two major sialoglycoproteins with molecular weights of 17 000 and 15 000 and two minor species of 70 000 and 54 000.
M. Chulavatnatol, C. Wongkome
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Purification and properties of brain alkaline phosphatase [PDF]
, 1976 Alkaline phosphatase from sheep brain has been purified to homogeneity. The method includes butanol extraction, fractional ethanol precipitation, ion-exchange chromatography on DEAE-cellulose, and on DEAE-Sephadex followed by Sephadex G-200 filtration ...
Bachhawat, B. K., Dorai, D. Thambi
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Clinical &Translational Immunology, Volume 13, Issue 9, September 2024.In this study, we found high Siglec‐7 and Siglec‐9 (ligand) expression in triple negative breast cancer, and to a lower extent in oestrogen receptor positive breast cancer. Moreover, signalling experiments demonstrated that Siglec‐7 signalling is induced by triple negative breast cancer cell lines.
Eline JH van Houtum +9 more
wiley +1 more source