Signal Recognition Particle in Human Diseases [PDF]
Frontiers in Genetics, 2022 The signal recognition particle (SRP) is a ribonucleoprotein complex with dual functions. It co-translationally targets proteins with a signal sequence to the endoplasmic reticulum (ER) and protects their mRNA from degradation.
Morgana K. Kellogg +2 more
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Molecular mechanism of cargo recognition and handover by the mammalian signal recognition particle [PDF]
Cell Reports, 2021 Summary: Co-translational protein targeting to membranes by the signal recognition particle (SRP) is a universally conserved pathway from bacteria to humans.
Ahmad Jomaa +6 more
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A signal recognition particle receptor gene from the sea cucumber, Apostichopus japonicus [PDF]
Scientific Reports, 2023 The signal recognition particle (SRP) system delivers approximately 30% of the proteome to the endoplasmic reticulum (ER) membrane. SRP receptor alpha (SRα) binds to SRP for targeting nascent secreted proteins to the ER membrane in eukaryotic cells.
Jian Zhang +5 more
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Dynamics of Bacterial Signal Recognition Particle at a Single Molecule Level [PDF]
Frontiers in Microbiology, 2021 We have studied the localization and dynamics of bacterial Ffh, part of the SRP complex, its receptor FtsY, and of ribosomes in the Gamma-proteobacterium Shewanella putrefaciens.
Benjamin Mayer +9 more
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Noncanonical Functions and Cellular Dynamics of the Mammalian Signal Recognition Particle Components [PDF]
Frontiers in Molecular Biosciences, 2021 The signal recognition particle (SRP) is a ribonucleoprotein complex fundamental for co-translational delivery of proteins to their proper membrane localization and secretory pathways.
Camilla Faoro, Sandro F. Ataide
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Signal Recognition Particle Suppressor Screening Reveals the Regulation of Membrane Protein Targeting by the Translation Rate [PDF]
mBio, 2021 Inner membrane proteins (IMPs) are cotranslationally inserted into the inner membrane or endoplasmic reticulum by the signal recognition particle (SRP).
Liuqun Zhao +5 more
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Posttranslational insertion of small membrane proteins by the bacterial signal recognition particle. [PDF]
PLoS Biology, 2020 Small membrane proteins represent a largely unexplored yet abundant class of proteins in pro- and eukaryotes. They essentially consist of a single transmembrane domain and are associated with stress response mechanisms in bacteria. How these proteins are
Ruth Steinberg +12 more
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Clinical Characteristics of Patients With Anti‐Signal Recognition Particle Antibody: A Cohort Study [PDF]
Immunity, Inflammation and DiseaseBackground Anti‐signal recognition particle (anti‐SRP) antibodies are myositis‐specific autoantibodies associated with immune‐mediated necrotizing myopathy.
Ameen Jubber +3 more
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Anti‐signal recognition particle antibodies induce cardiac diastolic dysfunction via oxidative stress injury [PDF]
Clinical & Translational ImmunologyObjectives Anti‐signal recognition particle (SRP) antibodies, markers of immune‐mediated necrotising myopathy, are reportedly related to cardiac involvement; however, whether they are pathogenic to the myocardium remains unclear.
Hao Zhang +18 more
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Factors associated with refractory autoimmune necrotizing myopathy with anti-signal recognition particle antibodies [PDF]
Orphanet Journal of Rare Diseases, 2020 Background Autoimmune necrotizing myopathy with anti-signal recognition particle antibodies (ANM-SRP) is regarded as refractory myositis, whereby some patients respond poorly to conventional immunosuppression and require B cell depletion treatment.
Yawen Zhao +4 more
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