Results 1 to 10 of about 403,629 (240)
904 Lupus Sex Bias and TLR7 Signaling [PDF]
Lupus Science and Medicine, 2022 Biji T Kurien +3 more
doaj +3 more sources
Gα Protein Signaling Bias at Serotonin 1A Receptor. [PDF]
Mol Pharmacol, 2023 Serotonin 1A receptor (5-HT1AR) is a clinically relevant target because of its involvement in several central and peripheral functions, including sleep, temperature homeostasis, processing of emotions, and response to stress. As a G protein coupled receptor (GPCR) activating numerous Gα i/o/z family members, 5-HT1AR can potentially modulate multiple ...
Alabdali R, Franchini L, Orlandi C.
europepmc +3 more sources
Resonating with the signaling bias of CXCR7. [PDF]
Mol Cell, 2022 Kleist et al. combine NMR spectroscopy and residue contact network analysis to identify a potential allosteric network in CXCR7, a β-arrestin-biased chemokine receptor, which links the extracellular ligand-binding pocket and the intracellular transducer-coupling region through the receptor transmembrane core.
Sarma P, Shukla AK.
europepmc +3 more sources
Overconfidence is a social signaling bias [PDF]
SSRN Electronic Journal, 2010 Evidence from psychology and economics indicates that many individuals overestimate their ability, both absolutely and relatively. We test three different theories about observed relative overconfidence.
Burks, Stephen V. +3 more
core +6 more sources
CD40 ligand dictated signaling bias
BLDE University Journal of Health Sciences, 2020 T cells are pivotal for innate and adaptive immune response. On, T cell a co-stimulatory molecule CD40 ligand is present that binds to the CD40 receptor.
Akshata Ganesh Bammigatti
doaj +2 more sources
Computationally designed GPCR quaternary structures bias signaling pathway activation [PDF]
Nature Communications, 2022 Computational modeling and design of G Protein-Coupled Receptor quaternary structures reveals a signaling bias switch at the receptor dimer interface that selectively controls G protein vs β-arrestin activation.
Justine S. Paradis +12 more
doaj +4 more sources
Arrestins: Introducing Signaling Bias Into Multifunctional Proteins. [PDF]
Prog Mol Biol Transl Sci, 2018 Arrestins were discovered as proteins that bind active phosphorylated G protein-coupled receptors (GPCRs) and block their interactions with G proteins, i.e., for their role in homologous desensitization of GPCRs. Mammals express only four arrestin subtypes, two of which are largely restricted to the retina.
Gurevich VV, Chen Q, Gurevich EV.
europepmc +4 more sources
Towards a behavioral theory of bias in signal detection [PDF]
Perception & Psychophysics, 1981 A behavioral model for performance on signal-detection tasks is presented. It is based on a relation between response and reinforcement ratios which has been derived from both animal and human research on the distribution of behavior between concurrently available schedules of reinforcement.
Dianne McCarthy, Michael Davison
openalex +4 more sources
Evaluating signaling bias for synthetic cannabinoid receptor agonists at the cannabinoid CB2 receptor [PDF]
Pharmacology Research & Perspectives, 2023 The rapid structural evolution and emergence of novel synthetic cannabinoid receptor agonists (SCRAs) in the recreational market remains a key public health concern.
Monica Patel +4 more
doaj +2 more sources
β-arrestin signalling and bias in hormone-responsive GPCRs [PDF]
Molecular and Cellular Endocrinology, 2017 G protein-coupled receptors (GPCRs) play crucial roles in the ability of target organs to respond to hormonal cues. GPCRs' activation mechanisms have long been considered as a two-state process connecting the agonist-bound receptor to heterotrimeric G proteins.
Éric Reiter +12 more
openalex +6 more sources