Belief bias is response bias: Evidence from a two-step signal detection model.
Journal of Experimental Psychology: Learning, Memory, and Cognition, 2018 When asked to determine whether a syllogistic argument is deductively valid, people are influenced by their prior beliefs about the believability of the conclusion. Recently, two competing explanations for this belief bias effect have been proposed, each based on signal detection theory (SDT).
Rachel Stephens +2 more
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Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors. [PDF]
Cell, 2023 Yadav MK +17 more
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Structurally Related Kappa Opioid Receptor Agonists with Substantial Differential Signaling Bias: Neuroendocrine and Behavioral Effects in C57BL6 Mice. [PDF]
Int J Neuropsychopharmacol, 2018 Dunn AD +5 more
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Phylogenetic Signal and Bias in Paleontology [PDF]
Systematic Biology, 2021 AbstractAn unprecedented amount of evidence now illuminates the phylogeny of living mammals and birds on the Tree of Life. We use this tree to measure the phylogenetic value of data typically used in paleontology (bones and teeth) from six data sets derived from five published studies.
Asher, Robert, Smith, Martin
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Mechanistic Insights into G Protein-Biased κ-Opioid Receptor Signaling Using Dual-Charged Naltrexamine Amides. [PDF]
J Med ChemDoering NP +10 more
europepmc +2 more sources
GPCR Binding and JNK3 Activation by Arrestin-3 Have Different Structural Requirements
Cells, 2023 Arrestins bind active phosphorylated G protein-coupled receptors (GPCRs). Among the four mammalian subtypes, only arrestin-3 facilitates the activation of JNK3 in cells.
Chen Zheng +5 more
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The Role of ICL1 and H8 in Class B1 GPCRs; Implications for Receptor Activation
Frontiers in Endocrinology, 2022 The first intracellular loop (ICL1) of G protein-coupled receptors (GPCRs) has received little attention, although there is evidence that, with the 8th helix (H8), it is involved in early conformational changes following receptor activation as well as ...
Ian Winfield +10 more
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Ligand bias in receptor tyrosine kinase signaling [PDF]
Journal of Biological Chemistry, 2020 Ligand bias is the ability of ligands to differentially activate certain receptor signaling responses compared with others. It reflects differences in the responses of a receptor to specific ligands and has implications for the development of highly specific therapeutics.
Kelly Karl +3 more
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Differential Signaling Profiles of MC4R Mutations with Three Different Ligands [PDF]
, 2020 The melanocortin 4 receptor (MC4R) is a key player in hypothalamic weight regulation and energy expenditure as part of the leptin-melanocortin pathway. Mutations in this G protein coupled receptor (GPCR) are the most common cause for monogenetic obesity,
Annibale, Paolo +8 more
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Nature Communications, 2023 Signaling bias is the ability of a receptor to differentially activate downstream signaling pathways in response to different ligands. Bias investigations have been hindered by inconsistent results in different cellular contexts.
Daniel Wirth +2 more
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