Results 21 to 30 of about 403,629 (240)
Structural basis of glucocorticoid receptor signaling bias
Journal of Neuroendocrinology, 2022 Abstract Dissociation between the healthy and toxic effects of cortisol, a major stress‐responding hormone has been a widely used strategy to develop anti‐inflammatory glucocorticoids with fewer side effects. Such strategy falls short when treating brain disorders as timing and activity state within large‐scale neuronal networks ...
Jeanneteau, Freddy +2 more
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Signal Evolution: ‘Shaky’ Evidence for Sensory Bias [PDF]
Current Biology, 2016 A study of tropical crickets suggests that a twitchy response to ultrasonic bat calls has been co-opted for mate location. The neuroethological approach picks apart some surprising evolutionary steps that could inform the widespread occurrence of complex duetting behaviour.
Pascoal, Sonia +2 more
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Parmodulins Inhibit Thrombus Formation Without Inducing Endothelial Injury Caused by Vorapaxar [PDF]
, 2015 Protease-activated receptor-1 (PAR1) couples the coagulation cascade to platelet activation during myocardial infarction and to endothelial inflammation during sepsis. This receptor demonstrates marked signaling bias.
Ahn +52 more
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Temporal Bias: Time-Encoded Dynamic GPCR Signaling [PDF]
Trends in Pharmacological Sciences, 2017 Evidence suggests that cells can time-encode signals for secure transport and perception of information, and it appears that this dynamic signaling is a common principle of nature to code information in time. G-protein-coupled receptor (GPCR) signaling networks are no exception as their composition and signal transduction appear temporally flexible. In
Manuel, Grundmann, Evi, Kostenis
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Frontiers in Immunology, 2020 The dramatic female sex bias observed in human lupus is thought to be due, at least in part, to estrogens. Using mouse models, we have shown that estrogens, acting through estrogen receptor alpha (ERα) promote lupus development and contribute ...
Jared H. Graham +2 more
doaj +1 more source
Bias in chemokine receptor signalling
Trends in Immunology, 2014 Chemokine receptors are widely expressed on a variety of immune cells and play a crucial role in normal physiology as well as in inflammatory and infectious diseases. The existence of 23 chemokine receptors and 48 chemokine ligands guarantees a tight control and fine-tuning of the immune system.
Zweemer, A.J.M. +3 more
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Stratification bias in low signal microarray studies [PDF]
BMC Bioinformatics, 2007 When analysing microarray and other small sample size biological datasets, care is needed to avoid various biases. We analyse a form of bias, stratification bias, that can substantially affect analyses using sample-reuse validation techniques and lead to inaccurate results.
Parker, Brian +2 more
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Frontiers in Pharmacology, 2019 Arrestin translocation and signaling have come to the fore of the G protein-coupled receptor molecular pharmacology field. Some receptor–arrestin interactions are relatively well understood and considered responsible for specific therapeutic or adverse ...
Mikkel Søes Ibsen +9 more
doaj +1 more source
Bias-inducing allosteric binding site in mu-opioid receptor signaling
SN Applied Sciences, 2021 G-protein-biased agonism of the mu-opioid receptor (μ-OR) is emerging as a promising strategy in analgesia. A deep understanding of how biased agonists modulate and differentiate G-protein-coupled receptors (GPCR) signaling pathways and how this is ...
Andrés F. Marmolejo-Valencia +2 more
doaj +1 more source
Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias
Frontiers in Pharmacology, 2021 The M1 and M4 muscarinic acetylcholine receptors (mAChRs) are highly pursued drug targets for neurological diseases, in particular for Alzheimer’s disease and schizophrenia.
Emma T. van der Westhuizen +7 more
doaj +1 more source