Results 31 to 40 of about 403,629 (240)
Environmental and Molecular Modulation of Motor Individuality in Larval Zebrafish
Frontiers in Behavioral Neuroscience, 2021 Innate behavioral biases such as human handedness are a ubiquitous form of inter-individual variation that are not strictly hardwired into the genome and are influenced by diverse internal and external cues.
John Hageter +11 more
doaj +1 more source
Molecular mechanism of biased signaling at the kappa opioid receptor
Nature Communications, 2023 Biased signaling in κ-opiod receptors (KOR) offer an attractive strategy for pain management. Here the authors identify determinants of KOR signaling bias using structural methods in combination with molecular dynamics simulations.
Amal El Daibani +13 more
doaj +1 more source
The negation bias: When negations signal stereotypic expectancies. [PDF]
Journal of Personality and Social Psychology, 2010 Research on linguistic biases shows that stereotypic expectancies are implicitly reflected in language and are thereby subtly communicated to message recipients. We examined whether these findings extend to the use of negations (e.g., not smart instead of stupid). We hypothesized that people use more negations in descriptions of stereotype-inconsistent
Beukeboom, C.J. +2 more
openaire +4 more sources
Affective Bias Through the Lens of Signal Detection Theory [PDF]
Computational Psychiatry, 2020 Affective bias - a propensity to focus on negative information at the expense of positive information - is a core feature of many mental health problems. However, it can be caused by wide range of possible underlying cognitive mechanisms. Here we illustrate this by focusing on one particular behavioural signature of affective bias - increased tendency ...
Shannon M. Locke, Oliver J. Robinson
openaire +5 more sources
Signaling Competence in Elections [PDF]
, 2013 We analyze how political candidates can signal their competence and show that polarization might be a way of doing this. For this purpose, we study a unidimensional Hotelling-Downs model of electoral competition in which a fraction of candidates have the
Honryo, Takakazu
core +2 more sources
Confirmation bias and signaling in Downsian elections [PDF]
Journal of Public Economics, 2020 How do voters' behavioural biases affect political outcomes? We study this question in a model of Downsian electoral competition in which office-motivated candidates have private information about the benefits of policies, and voters may infer candidates' information from their electoral platforms.
Millner, Antony +2 more
openaire +2 more sources
A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists
Frontiers in Pharmacology, 2019 Between 2000 and 2005 several studies revealed that morphine is more potent and exhibits fewer side effects in beta-arrestin 2 knockout mice. These findings spurred efforts to develop opioids that signal primarily via G protein activation and do not, or ...
Kendall L. Mores +6 more
doaj +1 more source
Functional selectivity of GPCR-directed drug action through location bias. [PDF]
, 2017 G-protein-coupled receptors (GPCRs) are increasingly recognized to operate from intracellular membranes as well as the plasma membrane. The β 2 -adrenergic GPCR can activate G s -linked cyclic AMP (G s -cAMP) signaling from endosomes.
Conti, Marco +6 more
core +3 more sources
Neurobiology of Disease, 2022 Schizophrenia is a psychiatric disorder that affects over 20 million people globally. Notably, schizophrenia is associated with decreased density of dendritic spines and decreased levels of d-serine, a co-agonist required for opening of the N-methyl-d ...
Deborah K. Park +6 more
doaj +1 more source
Reporting and Assessing the Quality of Diagnostic Accuracy Studies for Cervical Cancer Screening and Management. [PDF]
, 2020 ObjectiveWe adapted the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool for studies of cervical cancer screening and management and used the adapted tool to evaluate the quality of studies included in a systematic review supporting ...
Clarke, Megan A +8 more
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