Results 41 to 50 of about 403,629 (240)

Dose-Dependent Regulation on Prefrontal Neuronal Working Memory by Dopamine D1 Agonists: Evidence of Receptor Functional Selectivity-Related Mechanisms

Frontiers in Neuroscience, 2022
Low doses of dopamine D1 agonists improve working memory-related behavior, but high doses eliminate the improvement, thus yielding an ‘inverted-U’ dose-response curve.
Yang Yang, Yang Yang, Susan D. Kocher, Mechelle M. Lewis, Mechelle M. Lewis, Mechelle M. Lewis, Richard B. Mailman, Richard B. Mailman, Richard B. Mailman   +8 more
doaj   +1 more source

The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis. [PDF]

, 2018
Bone marrow mesenchymal stem cells (BMSCs), the important component and regulator of bone marrow microenvironment, give rise to hematopoietic-supporting stromal cells and form hematopoietic niches for hematopoietic stem cells (HSCs).
Li, Shengwen Calvin, Li, Zhongjun, Ran, Qian, Wu, Jiang, Xiang, Yang, Zhang, Weiwei, Zhong, Jiang F   +6 more
core   +2 more sources

Location bias contributes to functionally selective responses of biased CXCR3 agonists

Nature Communications, 2022
Subcellular signaling is critical to generating cellular responses that modulate inflammatory pathways at the chemokine receptor CXCR3. Eiger et al.
Dylan Scott Eiger, Noelia Boldizsar, Christopher Cole Honeycutt, Julia Gardner, Stephen Kirchner, Chloe Hicks, Issac Choi, Uyen Pham, Kevin Zheng, Anmol Warman, Jeffrey S. Smith, Jennifer Y. Zhang, Sudarshan Rajagopal   +12 more
doaj   +1 more source

BIAS IN SELF‐EVALUATION: SIGNAL PROBABILITY EFFECTS [PDF]

Journal of the Experimental Analysis of Behavior, 1994
Two experiments examined apparent signal probability effects in simple verbal self‐reports. After each trial of a delayed matching‐to‐sample task, young adults pressed either a “yes” or a “no” button to answer a computer‐presented query about whether the most recent choice met a point contingency requiring both speed and accuracy. A successful matching‐
openaire   +2 more sources

Physical constraints on accuracy and persistence during breast cancer cell chemotaxis [PDF]

, 2019
Directed cell motion in response to an external chemical gradient occurs in many biological phenomena such as wound healing, angiogenesis, and cancer metastasis.
Han, Bumsoo, Moon, Hye-ran, Mugler, Andrew, Saha, Soutick, Varennes, Julien   +4 more
core   +4 more sources

Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

eLife, 2019
Cytokines activate signaling via assembly of cell surface receptors, but it is unclear whether modulation of cytokine-receptor binding parameters can modify biological outcomes.
Jonathan Martinez-Fabregas, Stephan Wilmes, Luopin Wang, Maximillian Hafer, Elizabeth Pohler, Juliane Lokau, Christoph Garbers, Adeline Cozzani, Paul K Fyfe, Jacob Piehler, Majid Kazemian, Suman Mitra, Ignacio Moraga   +12 more
doaj   +1 more source

Cell biological mechanisms of activity-dependent synapse to nucleus translocation of CRTC1 in neurons. [PDF]

, 2015
Previous studies have revealed a critical role for CREB-regulated transcriptional coactivator (CRTC1) in regulating neuronal gene expression during learning and memory. CRTC1 localizes to synapses but undergoes activity-dependent nuclear translocation to
Ch'ng, Toh Hean, DeSalvo, Martina, Lin, Peter, Martin, Kelsey C, Vashisht, Ajay, Wohlschlegel, James A   +5 more
core   +1 more source

Bias Detection via Signaling

Advances in Neural Information Processing Systems 37
We introduce and study the problem of detecting whether an agent is updating their prior beliefs given new evidence in an optimal way that is Bayesian, or whether they are biased towards their own prior. In our model, biased agents form posterior beliefs that are a convex combination of their prior and the Bayesian posterior, where the more biased an ...
Chen, Yiling, Lin, Tao, Procaccia, Ariel D., Ramdas, Aaditya, Shapira, Itai   +4 more
openaire   +2 more sources

High-resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery

eLife
Deep Mutational Scanning (DMS) is an emerging method to systematically test the functional consequences of thousands of sequence changes to a protein target in a single experiment.
Conor J Howard, Nathan S Abell, Beatriz A Osuna, Eric M Jones, Leon Y Chan, Henry Chan, Dean R Artis, Jonathan B Asfaha, Joshua S Bloom, Aaron R Cooper, Andrew Liao, Eden Mahdavi, Nabil Mohammed, Alan L Su, Giselle A Uribe, Sriram Kosuri, Diane E Dickel, Nathan B Lubock   +17 more
doaj   +1 more source

REST/NRSF Knockdown Alters Survival, Lineage Differentiation and Signaling in Human Embryonic Stem Cells. [PDF]

, 2015
REST (RE1 silencing transcription factor), also known as NRSF (neuron-restrictive silencer factor), is a well-known transcriptional repressor of neural genes in non-neural tissues and stem cells.
Jan, Majib, John, Alan, Koleilat, Tasneem, Pyle, April D, Thakore-Shah, Kaushali   +4 more
core   +3 more sources