Results 1 to 10 of about 8,752,965 (357)
Keap1/Nrf2 Signaling Pathway [PDF]
Antioxidants, 2021 Nuclear factor, erythroid 2-like transcription factor 2 (Nrf2) and its cytoplasmic inhibitor, kelch-like ECH-associated protein 1 (Keap1), comprise a redox-responsive endogenous antioxidant defense module that orchestrates the expression of ...
Gerasimos P. Sykiotis
doaj +4 more sources
The JAK/STAT signaling pathway: from bench to clinic
Signal Transduction and Targeted Therapy, 2021 The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus ...
Xiaoying Hu +4 more
semanticscholar +1 more source
A review of signal pathway induced by virulent protein CagA of Helicobacter pylori
Frontiers in Cellular and Infection Microbiology, 2023 Gastric cancer (GC), a common and high-mortality disease, still occupies an important position in current cancer research, and Helicobacter pylori (H. pylori) infection as its important risk factor has been a hot and challenging research area.
Haiqiang Wang +5 more
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PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
Molecular Cancer, 2023 The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell cycle progression.
Antonino Glaviano +26 more
semanticscholar +1 more source
Biology, 2021 Long-term imbalance between fatigue and recovery may eventually lead to muscle weakness or even atrophy. We previously reported that excessive exercise induces pathological cardiac hypertrophy.
Chen-Chen Sun +7 more
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Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer
Signal Transduction and Targeted Therapy, 2023 The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway is an evolutionarily conserved mechanism of transmembrane signal transduction that enables cells to communicate with the exterior environment.
Chen Xue +8 more
semanticscholar +1 more source
Targeting PI3K/AKT signaling pathway in obesity.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023 Obesity is a disorder with an increasing prevalence, which impairs the life quality of patients and intensifies societal health care costs. The development of safe and innovative prevention strategies and therapeutic approaches is thus of great ...
Martina S. Savova +4 more
semanticscholar +1 more source
Frontiers in Genetics, 2022 Osteosarcoma (OS) is a common bone cancer in children and adolescents, and metastasis and recurrence are the major causes of poor treatment outcomes. A better understanding of the tumor microenvironment is required to develop an effective treatment for ...
Ning Xu +6 more
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Progress of Wnt Signaling Pathway in Osteoporosis
Biomolecules, 2023 Osteoporosis, one of the serious health diseases, involves bone mass loss, bone density diminishing, and degeneration of bone microstructure, which is accompanied by a tendency toward bone fragility and a predisposition to fracture. More than 200 million
Yongguang Gao +3 more
semanticscholar +1 more source
Notch signaling pathway: architecture, disease, and therapeutics
Signal Transduction and Targeted Therapy, 2022 The NOTCH gene was identified approximately 110 years ago. Classical studies have revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors undergo three cleavages and translocate into the nucleus to regulate the transcription
Binghan Zhou +6 more
semanticscholar +1 more source