Results 91 to 100 of about 8,752,965 (357)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The involvement of exosomes in the tumorigenicity of breast cancer cell lines through the crosstalk between STAT3, Notch, and Wnt signaling pathways

Discover Oncology
Background Exosomes play a critical role in the tumor microenvironment by interacting with signaling pathways that facilitate breast cancer metastasis, particularly the STAT3 pathway.
Shymaa Abdullah Mohamed, Toka M. I. Badawy, Menna Allah M. K. Hussein, Mohammed Salama, Yasser M. El Kerm, Mohamed A. Abdel Mohsen   +5 more
doaj   +1 more source

Inhibition of H3K9me2 Reduces Hair Cell Regeneration after Hair Cell Loss in the Zebrafish Lateral Line by Down-Regulating the Wnt and Fgf Signaling Pathways

Frontiers in Molecular Neuroscience, 2016
The activation of neuromast supporting cell (SC) proliferation leads to hair cell (HC) regeneration in the zebrafish lateral line. Epigenetic mechanisms have been reported that regulate HC regeneration in the zebrafish lateral line, but the role of ...
Dongmei eTang, Qin eLin, Yingzi eHe, Renjie eChai, Renjie eChai, Huawei eLi, Huawei eLi, Huawei eLi, Huawei eLi   +8 more
doaj   +1 more source

HOXA10 enhances cell proliferation and suppresses apoptosis in esophageal cancer via activating p38/ERK signaling pathway

Open Medicine, 2022
Esophageal cancer (EC) is an extremely aggressive malignant tumor. Homeobox A10 (HOXA10) is highly expressed and plays an important role in a variety of tumors. However, the function of HOXA10 in EC remains unclear.
Jiang Lifeng, Yang Qixian
doaj   +1 more source

Regulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in medulloblastoma and astrocytoma [PDF]

, 2010
Background The Sonic hedgehog (Shh) signaling pathway is critical for cell growth and differentiation. Impairment of this pathway can result in both birth defects and cancer.
Afzal, Mohammad, Castresana, Javier S, Eberhart, Charles G., Fan, Xing, Rey, Juan A, Shahi, Mehdi H, Sinha, Subrata   +6 more
core   +5 more sources

Role of the NF-κB signaling pathway in the pathogenesis of colorectal cancer.

Gene, 2020
The NF-κB signaling pathway is a key regulator of CRC cell proliferation, apoptosis, angiogenesis, inflammation, metastasis, and drug resistance. Over-activation of the NF-κB pathway is a feature of colorectal cancer (CRC).
Atena Soleimani, F. Rahmani, G. Ferns, Mikhail Ryzhikov, A. Avan, S. M. Hassanian   +5 more
semanticscholar   +1 more source

Signal Pathways in Cancer

International Journal of Molecular Sciences, 2023
Cancer is a major health-threatening disease and is the second leading cause of death worldwide; the prevention and treatment of cancer remains one of the most challenging problems clinically [...]
openaire   +2 more sources

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

The protective effect of naringenin on ulcerative colitis in mice through increasing Nrf2 pathway activity

Acta Biochimica et Biophysica Sinica
Ulcerative colitis (UC) is a chronic inflammatory disease with an increasing prevalence worldwide. Naringenin (NAR) has been proven effective in preventing UC, but its mechanism has not been fully elucidated.
Li Jiaxiang, Hua Li, Hu Meichun, Zhu Ni, Dong Sijin, Jing Xiaoli, Zhu Zihuan, Liu Yifei, Zhou Yanhong   +8 more
doaj   +1 more source

Association of Wnt1-inducible signaling pathway protein-1 with the proliferation, migration and invasion in gastric cancer cells

Tumor Biology, 2017
Wnt1-inducible signaling pathway protein-1 is a cysteine-rich protein that belongs to the CCN family, which has been implicated in mediating the occurrence and progression through distinct molecular mechanisms in several tumor types.
Shuqin Jia, Tingting Qu, Mengmeng Feng, Ke Ji, Ziyu Li, Wenguo Jiang, Jiafu Ji   +6 more
doaj   +1 more source