Results 231 to 240 of about 1,424,654 (267)

Insulin signal transduction pathways

Trends in Endocrinology & Metabolism, 1994
Insulin initiates its pleiotropic effects by activating the insulin receptor tyrosine kinase to phosphorylate several intracellular proteins. Recent studies have demonstrated that phosphotyrosine residues bind specifically to proteins that contain src homology 2 (SH2) domains, and that this interaction mediates the regulation of multiple intracellular ...
M J, Quon, A J, Butte, S I, Taylor
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Cytokine receptor signaling pathways

Journal of Allergy and Clinical Immunology, 2000
Cytokines represent a diverse group of molecules that transmit intercellular signals. These signals may either be autocrine (where the same cell both produces the cytokine and responds to it) or paracrine (where the cytokine is made by one cell and acts on another). Both these situations can occur simultaneously.
W J, Leonard, J X, Lin
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Polyphenols: Novel Signaling Pathways

Current Pharmaceutical Design, 2018
Background: Cardiovascular disease (CVD) is currently the leading cause of death globally. The metabolic syndrome (MetS), a clustering of risk factors including hypertension, hyperglycemia, elevated low-density lipoprotein (LDL) cholesterol, reduced high-density lipoprotein (HDL) cholesterol and increased visceral adiposity, is a significant risk ...
Marie-Louise, Ricketts, Bradley S, Ferguson   +1 more
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LKB1-Dependent Signaling Pathways

Annual Review of Biochemistry, 2006
This review focuses on remarkable recent findings concerning the mechanism by which the LKB1 protein kinase that is mutated in Peutz-Jeghers cancer syndrome operates as a tumor suppressor. We discuss evidence that the cellular localization and activity of LKB1 is controlled through its interaction with a catalytically inactive protein resembling a ...
Dario R, Alessi, Kei, Sakamoto, Jose R, Bayascas   +2 more
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Myocyte Adrenoceptor Signaling Pathways

Science, 2003
Adrenoceptors (ARs), members of the G protein–coupled receptor superfamily, form the interface between the sympathetic nervous system and the cardiovascular system, with integral roles in the rapid regulation of myocardial function. However, in heart failure, chronic catecholamine stimulation of adrenoceptors has been linked to pathologic cardiac ...
Yang, Xiang, Brian K, Kobilka
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Dissecting kinase signaling pathways

Drug Discovery Today, 2007
Aberrant protein kinase signaling is a hallmark of many human diseases including cancer, diabetes, and neurological disorders. Kinase inhibitors have shown to be successful at treating some of these diseases, implying that understanding kinase signaling pathways may lead to additional, non-kinase drug targets. However, identifying substrates of protein
Scott N, Boyle, Anthony J, Koleske
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Druggable Lysophospholipid Signaling Pathways

2020
Lysophosphatidic acid (LPA) has major roles as a bioactive signaling molecule, with multiple physiological and pathological roles being described in almost every major organ system. In this review we discuss LPA signaling pathways as emerging drug targets for multiple conditions relevant to human health and disease.
Keisuke, Yanagida, William J, Valentine
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CD45 Regulated Signaling Pathways

Current Topics in Medicinal Chemistry, 2003
CD45 is expressed on all nucleated haematopoietic cells and was originally identified as the first and prototypic transmembrane protein tyrosine phosphatase (PTPase). CD45 has been extensively studied for over two decades as a PTPase that functions in antigen receptor signaling by dephosphorylation of Src-kinases. CD45 can operate as a positive as well
Junko, Irie-Sasaki, Takehiko, Sasaki, Josef M, Penninger   +2 more
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CGRP Receptor Signalling Pathways

2018
Calcitonin gene-related peptide (CGRP) is a promiscuous peptide, similar to many other members of the calcitonin family of peptides. The potential of CGRP to act on many different receptors with differing affinities and efficacies makes deciphering the signalling from the CGRP receptor a challenging task for researchers.Although it is not a typical G ...
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Alternate interferon signaling pathways

Pharmacology & Therapeutics, 2003
More than a half a century ago, interferons (IFN) were identified as antiviral cytokines. Since that discovery, IFN have been in the forefront of basic and clinical cytokine research. The pleiotropic nature of these cytokines continues to engage a large number of investigators to define their actions further.
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