Results 21 to 30 of about 8,752,965 (357)

SnapShot: PTEN Signaling Pathways [PDF]

Cell, 2008
is causative for familial diseases including Cowden syndrome, which is characterized by multiple hamartomas, developmental defects, and increased cancer susceptibility.The major tumor-suppressive activity of PTEN is attributed to its ability to hydrolyze the 3′ phosphate of phosphoinositides at the plasma membrane and thereby negatively regulate ...
Carracedo A, Salmena L, PANDOLFI DE RINALDIS, Pier Paolo   +2 more
openaire   +2 more sources

Notoginsenoside R1-loaded mesoporous silica nanoparticles targeting the site of injury through inflammatory cells improves heart repair after myocardial infarction

Redox Biology, 2022
Notoginsenoside R1 (NGR1) is the main monomeric component extracted from the dried roots and rhizomes of Panax notoginseng, and exerts pharmacological action against myocardial infarction (MI).
Han Li, Jing Zhu, Yan-wu Xu, Fang-fang Mou, Xiao-li Shan, Qiang-li Wang, Bao-nian Liu, Ke Ning, Jia-jia Liu, Ya-chao Wang, Jin-xia Mi, Xiaohui Wei, Shui-jin Shao, Guo-hong Cui, Rong Lu, Hai-dong Guo   +15 more
doaj   +1 more source

Comparative analysis of the root transcriptomes of cultivated and wild rice varieties in response to Magnaporthe oryzae infection revealed both common and species-specific pathogen responses

Rice, 2018
Background Magnaporthe oryzae, the causal fungus of rice blast disease, negatively impacts global rice production. Wild rice (Oryza rufipogon), a relative of cultivated rice (O.
Lei Tian, Shaohua Shi, Fahad Nasir, Chunling Chang, Weiqiang Li, Lam-Son Phan Tran, Chunjie Tian   +6 more
doaj   +1 more source

Elevated intracellular cAMP exacerbates vulnerability to oxidative stress in optic nerve head astrocytes. [PDF]

, 2018
Glaucoma is characterized by a progressive loss of retinal ganglion cells and their axons, but the underlying biological basis for the accompanying neurodegeneration is not known.
Bu, Jung Hyun, Ellisman, Mark H, Jeong, Seung Won, Ju, Won-Kyu, Kim, Keun-Young, Nam, Hye Seung, Park, Tae Lim, Shim, Myoung Sup, Weinreb, Robert N   +8 more
core   +2 more sources

Ethanol Enhances High-Salinity Stress Tolerance by Detoxifying Reactive Oxygen Species in Arabidopsis thaliana and Rice

Frontiers in Plant Science, 2017
High-salinity stress considerably affects plant growth and crop yield. Thus, developing techniques to enhance high-salinity stress tolerance in plants is important.
Huong Mai Nguyen, Huong Mai Nguyen, Kaori Sako, Kaori Sako, Akihiro Matsui, Yuya Suzuki, Yuya Suzuki, Mohammad Golam Mostofa, Chien Van Ha, Maho Tanaka, Lam-Son Phan Tran, Yoshiki Habu, Yoshiki Habu, Motoaki Seki, Motoaki Seki, Motoaki Seki   +15 more
doaj   +1 more source

Is NO the Answer? The Nitric Oxide Pathway Can Support Bone Morphogenetic Protein 2 Mediated Signaling [PDF]

, 2019
The growth factor bone morphogenetic protein 2 (BMP2) plays an important role in bone development and repair. Despite the positive effects of BMP2 in fracture healing, its use is associated with negative side effects and poor cost effectiveness, partly ...
Bormann, Nicole, Differ, Christopher, Klatte-Schulz, Franka, Knaus, Petra, Minkwitz, Susann, Wildemann, Britt   +5 more
core   +1 more source

The Smad Dependent TGF-β and BMP Signaling Pathway in Bone Remodeling and Therapies

Frontiers in Molecular Biosciences, 2021
Bone remodeling is a continuous process that maintains the homeostasis of the skeletal system, and it depends on the homeostasis between bone-forming osteoblasts and bone-absorbing osteoclasts.
M. Zou, Zhong-hua Chen, Ying-ying Teng, Si-Yu Liu, Yuan Jia, Kai-Wen Zhang, Zi-Li Sun, Jun-Jie Wu, Zheng-Dong Yuan, Yi Feng, Xia Li, Rui-sheng Xu, Feng-Lai Yuan   +12 more
semanticscholar   +1 more source

A Single-Cell Atlas of an Early Mongolian Sheep Embryo

Veterinary Sciences, 2023
Cell types have been established during organogenesis based on early mouse embryos. However, our understanding of cell types and molecular mechanisms in the early embryo development of Mongolian sheep has been hampered.
Tingyi He, Wenrui Guo, Guang Yang, Hong Su, Aolei Dou, Lu Chen, Teng Ma, Jie Su, Moning Liu, Budeng Su, Wangmei Qi, Haijun Li, Wei Mao, Xiumei Wang, Xihe Li, Yanyan Yang, Yongli Song, Guifang Cao   +17 more
doaj   +1 more source

Wnt signaling during tooth replacement in zebrafish (Danio rerio) : pitfalls and perspectives [PDF]

, 2014
The canonical (13-catenin dependent) Wnt signaling pathway has emerged as a likely candidate for regulating tooth replacement in continuously renewing dentitions.
Elderweirdt, Fien, Huysseune, Ann, Soenens, Mieke   +2 more
core   +3 more sources

Hedgehog/GLI Signaling Pathway: Transduction, Regulation, and Implications for Disease

Cancers, 2021
Simple Summary The Hedgehog/GLI (Hh/GLI) pathway plays a major role during development and it is commonly dysregulated in many diseases, including cancer.
Ashley N. Sigafoos, Brooke D. Paradise, M. Fernandez-Zapico   +2 more
semanticscholar   +1 more source