Results 41 to 50 of about 8,752,965 (357)
An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation
Molecules, 2020 Inflammation is a key driver in many pathological conditions such as allergy, cancer, Alzheimer’s disease, and many others, and the current state of available drugs prompted researchers to explore new therapeutic targets.
S. Saha +4 more
semanticscholar +1 more source
The role of myofibroblasts in orthodontic tooth movement
口腔疾病防治, 2019 Myofibroblasts are fibroblasts with contractile function. As a contractile cell, myofibroblasts can regulate the function of normal organs in normal tissues.
PAN Xumeng, LIU Yi
doaj +1 more source
“Biomechanical Signaling in Oocytes and Parthenogenetic Cells”
Frontiers in Cell and Developmental Biology, 2021 Oocyte-specific competence remains one of the major targets of current research in the field of reproduction. Several mechanisms are involved in meiotic maturation and the molecular signature of an oocyte is considered to reflect its quality and to ...
Georgia Pennarossa +2 more
doaj +1 more source
Adenine Nucleotide Translocase 1 Expression is Coupled to the HSP27-Mediated TLR4 Signaling in Cardiomyocytes [PDF]
, 2019 The cardiac-specific overexpression of the adenine nucleotide translocase 1 (ANT1) has cardioprotective effects in various experimental heart disease models.
Dörner, Andrea +6 more
core +2 more sources
Genomic alterations of oligodendrogliomas at distant recurrence
Cancer Medicine, 2023 Background Oligodendroglioma is known for its relatively better prognosis and responsiveness to radiotherapy and chemotherapy. However, little is known about the evolution of genetic changes as oligodendroglioma progresses.
Guanzheng Liu +15 more
doaj +1 more source
Differential Signaling Profiles of MC4R Mutations with Three Different Ligands [PDF]
, 2020 The melanocortin 4 receptor (MC4R) is a key player in hypothalamic weight regulation and energy expenditure as part of the leptin-melanocortin pathway. Mutations in this G protein coupled receptor (GPCR) are the most common cause for monogenetic obesity,
Annibale, Paolo +8 more
core +3 more sources
Engineering Signal Transduction Pathways [PDF]
Cell, 2010 Cells respond to their environment by sensing signals and translating them into changes in gene expression. In recent years, synthetic networks have been designed in both prokaryotic and eukaryotic systems to create new functionalities and for specific applications.
Kiel, Christina, Yus, Eva, Serrano, Luis
openaire +3 more sources
Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy
Journal of Hematology & OncologyThe Wnt/β-catenin signaling pathway plays a crucial role in various physiological processes, encompassing development, tissue homeostasis, and cell proliferation.
Pan Song +7 more
semanticscholar +1 more source
A Salmonella virulence factor activates the NOD1/NOD2 signaling pathway. [PDF]
, 2011 The invasion-associated type III secretion system (T3SS-1) of Salmonella enterica serotype Typhimurium (S. Typhimurium) activates the transcription factor NF-κB in tissue culture cells and induces inflammatory responses in animal models through unknown ...
Bäumler, Andreas J +7 more
core +2 more sources
Notch signaling pathway in cancer: from mechanistic insights to targeted therapies
Signal Transduction and Targeted TherapyNotch signaling, renowned for its role in regulating cell fate, organ development, and tissue homeostasis across metazoans, is highly conserved throughout evolution.
Qingmiao Shi +9 more
semanticscholar +1 more source