Research progress on the interaction between ferroptosis and inflammatory signaling pathway
Zhongguo linchuang yanjiuFerroptosis is a form of cell death characterized by iron-dependent lipid peroxidation and the accumulation of reactive oxygen species, distinct from apoptosis and other forms of cell death.
LI Yaling, BAI Yihua, FAN Yang, HUANG Lilan
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The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway
Cell, 2020 Alzheimer's disease, obesity-related metabolic syndrome, and cancer are the leading causes of death and among the most costly medical conditions in the Western world.
A. Deczkowska, A. Weiner, I. Amit
semanticscholar +1 more source
PI3K/AKT signaling pathway: Molecular mechanisms and therapeutic potential in depression.
Pharmacological ResearchDepression is a serious global mental disorder. Numerous studies have found that depression may be closely related to decreased neurogenesis, neuroinflammation, neurotransmitter imbalance, and synaptic plasticity dysfunction.
Ningning Guo +5 more
semanticscholar +1 more source
PI3K/AKT/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to Clinical Aspects
International Journal of Molecular Sciences, 2020 Breast cancer is a serious health problem worldwide, representing the second cause of death through malignancies among women in developed countries. Population, endogenous and exogenous hormones, and physiological, genetic and breast-related factors are ...
D. Miricescu +5 more
semanticscholar +1 more source
The Regulatory Role of MeAIB in Protein Metabolism and the mTOR Signaling Pathway in Porcine Enterocytes. [PDF]
, 2018 Amino acid transporters play an important role in cell growth and metabolism. MeAIB, a transporter-selective substrate, often represses the adaptive regulation of sodium-coupled neutral amino acid transporter 2 (SNAT2), which may act as a receptor and ...
Ji, Peng +5 more
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The Hippo signaling pathway in development and regeneration.
Cell ReportsThe Hippo signaling pathway is a central growth control mechanism in multicellular organisms. By integrating diverse mechanical, biochemical, and stress cues, the Hippo pathway orchestrates proliferation, survival, differentiation, and mechanics of cells,
Zhenxing Zhong, Z. Jiao, Fa-Xing Yu
semanticscholar +1 more source
Exploring the mechanisms of lithium neurotoxicity based on network toxicology and molecular docking
Ecotoxicology and Environmental SafetyThe rapid growth of lithium (Li)-related industrial activities and the application of Li-containing products have become an emerging human health concern.
Wei Wei +4 more
doaj +1 more source
mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges
Cell & Bioscience, 2020 Mammalian target of rapamycin (mTOR) regulates cell proliferation, autophagy, and apoptosis by participating in multiple signaling pathways in the body. Studies have shown that the mTOR signaling pathway is also associated with cancer, arthritis, insulin
Zhilin Zou +3 more
semanticscholar +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background The delipid extracorporeal lipoprotein filter from plasma (DELP) treatment can effectively reduce blood lipid, increase blood flow, and improve neurological deficits in patients with acute ischemic stroke (AIS). However, its effect on vision and retinal microcirculation in stroke patients has never been reported.
Ning Li +9 more
wiley +1 more source
Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates pro-apoptotic signaling involving caspase 9 and mitochondrial release of endonuclease G [PDF]
, 2005 BACKGROUND: In type 2 diabetes, free fatty acids (FFA) accumulate in microvascular cells, but the phenotypic consequences of FFA accumulation in the microvasculature are incompletely understood. Here we investigated whether saturated FFA induce apoptosis
Mishra, Rangnath, Simonson, Michael S
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