Results 61 to 70 of about 8,752,965 (357)
The PI3K/AKT/mTOR signaling pathway in osteoarthritis: a narrative review.
Osteoarthritis and Cartilage, 2020 Osteoarthritis (OA) is a complicated degenerative disease that affects whole joint tissue. Currently, apart from surgical approaches to treat late stage OA, effective treatments to reverse OA are not available.
Kai Sun +5 more
semanticscholar +1 more source
The insulin signalling pathway [PDF]
Current Biology, 2002 A key aim for future research is to identify the hydrophobic motif kinase that phosphorylates PKB, S6K, SGK and to establish how this protein kinase(s) is regulated by PtdIns(3,4,5)P3. It is also becoming obvious that the information obtained by the overexpression of constitutively active and dominant negative mutants of protein kinases is not ...
Lizcano, Jose M., Alessi, Dario R.
openaire +2 more sources
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
Role of mTOR signaling in tumor microenvironment. An overview [PDF]
, 2018 The mammalian target of rapamycin (mTOR) pathway regulates major processes by integrating a variety of exogenous cues, including diverse environmental inputs in the tumor microenvironment (TME).
Bazzichetto, Chiara +8 more
core +2 more sources
Wnt signal transduction pathways [PDF]
Organogenesis, 2008 The Wnt signaling pathway is an ancient and evolutionarily conserved pathway that regulates crucial aspects of cell fate determination, cell migration, cell polarity, neural patterning and organogenesis during embryonic development. The Wnts are secreted glycoproteins and comprise a large family of nineteen proteins in humans hinting to a daunting ...
Yuko, Komiya, Raymond, Habas
openaire +2 more sources
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Animals, 2021 Chicken is important livestock that serves as a vital food source which remain largely affected by heat stress. Therefore, we performed the transcriptome analysis to help understand the mechanisms of heat stress response in chickens.
Hana Kim +6 more
doaj +1 more source
HSV-2 Infection of Human Genital Epithelial Cells Upregulates TLR9 Expression Through the SP1/JNK Signaling Pathway [PDF]
, 2020 It is known that herpes simplex virus type 2 (HSV-2) triggers the activation of Toll-like receptor (TLR) 9 signaling pathway and the consequent production of antiviral cytokines in dendritic cells.
Barreto, M +11 more
core +1 more source
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020 Aberrant scar formation, which includes keloid and hypertrophic scars, is associated with a pathological disorganized wound healing process with chronic inflammation.
Tao Zhang +9 more
semanticscholar +1 more source
Retroactive Signaling in Short Signaling Pathways
PLoS ONE, 2012 في مسارات الإشارات الكيميائية الحيوية دون وصلات تغذية مرتدة صريحة، عادة ما يوصف نقل الإشارة الأساسية بأنه اتصال أحادي الاتجاه، ينتقل من المنبع إلى المصب في سلسلة تغذية أمامية أو شبكة من دورات التعديل التساهمية. في هذه الورقة، نستكشف إمكانية وجود نوع جديد من الإشارات يسمى الإشارات بأثر رجعي، والتي توفرها الخاصية التي تم إظهارها مؤخرًا للأثر الرجعي في ...
Jacques Alexandre Sepulchre +2 more
openaire +5 more sources