Results 71 to 80 of about 8,752,965 (357)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
口腔疾病防治, 2019 Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia, often accompanied by bone metabolic disorders, microvascular diseases, etc.
JIANG Xue, YANG Qiyuan, LIAO Wen
doaj +1 more source
Frontiers in Endocrinology, 2022 Androgen receptor signaling pathway is necessary to complete spermatogenesis in testes. Difference between androgen binding location in Sertoli cell classifies androgen receptor signaling pathway into classical signaling pathway and non-classical ...
Jia-Ming Wang, Zhen-Fang Li, Wan-Xi Yang
doaj +1 more source
Signaling Pathways in Pregnancy
Cells, 2022 We are pleased to present this Special Issue of Cells, entitled ‘Signaling Pathways in Pregnancy’ [...]
Giovanni Tossetta, Daniela Marzioni
openaire +3 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes [PDF]
, 2007 CD38 controls the chemotaxis of leukocytes to some, but not all, chemokines, suggesting that chemokine receptor signaling in leukocytes is more diverse than previously appreciated.
Borchers, Michael T. +7 more
core +2 more sources
Growth hormone signaling pathways
Growth Hormone & IGF Research, 2016 Over 20years ago, our laboratory showed that growth hormone (GH) signals through the GH receptor-associated tyrosine kinase JAK2. We showed that GH binding to its membrane-bound receptor enhances binding of JAK2 to the GHR, activates JAK2, and stimulates tyrosyl phosphorylation of both JAK2 and GHR.
Christin, Carter-Su +2 more
openaire +3 more sources
Signaling Pathways in Melanogenesis [PDF]
International Journal of Molecular Sciences, 2016 Melanocytes are melanin-producing cells found in skin, hair follicles, eyes, inner ear, bones, heart and brain of humans. They arise from pluripotent neural crest cells and differentiate in response to a complex network of interacting regulatory pathways. Melanins are pigment molecules that are endogenously synthesized by melanocytes.
Stacey D’Mello +3 more
openaire +3 more sources
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
LNK suppresses interferon signaling in melanoma. [PDF]
, 2019 LNK (SH2B3) is a key negative regulator of JAK-STAT signaling which has been extensively studied in malignant hematopoietic diseases. We found that LNK is significantly elevated in cutaneous melanoma; this elevation is correlated with hyperactive ...
Ding, Ling-Wen +19 more
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