Results 11 to 20 of about 1,476,364 (294)

SnapShot: PTEN Signaling Pathways [PDF]

Cell, 2008
is causative for familial diseases including Cowden syndrome, which is characterized by multiple hamartomas, developmental defects, and increased cancer susceptibility.The major tumor-suppressive activity of PTEN is attributed to its ability to hydrolyze the 3′ phosphate of phosphoinositides at the plasma membrane and thereby negatively regulate ...
Carracedo A, Salmena L, PANDOLFI DE RINALDIS, Pier Paolo   +2 more
openaire   +2 more sources

Moonlight functions of glycolytic enzymes in cancer

Frontiers in Molecular Biosciences, 2023
Since an extensive genome research has started, basic principle “one gene—one protein—one function” was significantly revised. Many proteins with more than one function were identified and characterized as “moonlighting” proteins, which activity depend ...
Petr V. Shegay, Olga P. Shatova, Olga P. Shatova, Anastasia A. Zabolotneva, Anastasia A. Zabolotneva, Aleksandr V. Shestopalov, Aleksandr V. Shestopalov, Aleksandr V. Shestopalov, Andrei D. Kaprin, Andrei D. Kaprin   +9 more
doaj   +1 more source

Genetic alterations in melanoma [PDF]

Medicinski Podmladak
Melanoma, an aggressive skin tumor with a high mortality rate in advanced stages, represents a global health challenge. Genetic alterations play a pivotal role in its onset and progression.
Đunjić Marija, Perović Dijana, Šupić Gordana   +2 more
doaj   +1 more source

Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells

Nature Communications, 2018
The c-MYC oncoprotein has many targets whose actions are not fully understood including TFAP4/AP4. Here, the authors show in a mouse model of inherited colorectal cancer that deletion of AP4 decreased the frequency of c-MYC-driven intestinal adenomas ...
Stephanie Jaeckel, Markus Kaller, Rene Jackstadt, Ursula Götz, Susanna Müller, Sophie Boos, David Horst, Peter Jung, Heiko Hermeking   +8 more
doaj   +1 more source

Deregulation of Interferon Signaling in Malignant Cells

Pharmaceuticals, 2010
Interferons (IFNs) are a family of cytokines with potent antiproliferative, antiviral, and immunomodulatory properties. Much has been learned about IFNs and IFN-activated signaling cascades over the last 50 years. Due to their potent antitumor effects in
Leonidas C. Platanias, Surinder Kaur, Efstratios Katsoulidis   +2 more
doaj   +1 more source

The Role of Curcumin in Cancer Treatment

Biomedicines, 2021
Curcumin is a polyphenol extracted from the rhizomes of the turmeric plant, Curcuma longa which has anti-inflammatory, and anticancer properties. Chronic inflammation is associated with the development of cancer.
Vasiliki Zoi, Vasiliki Galani, Georgios D. Lianos, Spyridon Voulgaris, Athanasios P. Kyritsis, George A. Alexiou   +5 more
doaj   +1 more source

Modaline sulfate promotes Oct4 expression and maintains self-renewal and pluripotency of stem cells through JAK/STAT3 and Wnt signaling pathways

Cell & Bioscience, 2021
Background Stem cells have been extensively explored for a variety of regenerative medical applications and they play an important role in clinical treatment of many diseases.
Xianglin Mei, Hanhan Zhao, Huihan Ai, Shuyue Wang, Zhenbo Song, Lihua Zheng, Guannan Wang, Ying Sun, Yongli Bao   +8 more
doaj   +1 more source

Mechanisms Underlying Influence of Bioelectricity in Development

Frontiers in Cell and Developmental Biology, 2022
To execute the intricate process of development, cells coordinate across tissues and organs to determine where each cell divides and differentiates. This coordination requires complex communication between cells.
Laura Faith George, Emily Anne Bates
doaj   +1 more source

Integrated analysis of microRNA and mRNA expression profiles in Preeclampsia

BMC Medical Genomics, 2023
Background Preeclampsia (PE), a pregnancy specific syndrome, is one kind of common gestational hypertension disease, which can cause maternal and perinatal mortality and morbidity.
Zepeng Ping, Ying Feng, Ying Lu, Ling Ai, Huling Jiang   +4 more
doaj   +1 more source

Exercise-induced signaling pathways to counteracting cardiac apoptotic processes

Frontiers in Cell and Developmental Biology, 2022
Cardiovascular diseases are the most common cause of death in the world. One of the major causes of cardiac death is excessive apoptosis. However, multiple pathways through moderate exercise can reduce myocardial apoptosis.
Hamed Alizadeh Pahlavani
doaj   +1 more source