Results 11 to 20 of about 2,211,530 (330)
International Journal of Molecular Sciences, 2021 p38 Mitogen activated protein kinases (p38MAPK) are a highly evolutionary conserved group of protein kinases, which are central for cell adaptation to environmental changes as well as for immune response, inflammation, tissue regeneration, and tumour formation [...]
Juan José Sanz-Ezquerro, Ana Cuenda
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Signaling Pathways in Gliomas. [PDF]
Genes (Basel)Changes in cell signaling pathways, which in normal conditions determine the maintenance of cell homeostasis and the correctness of its basic processes, may cause the transformation of a normal cell into a cancer cell. Alterations in cellular metabolism leading to oncogenesis are considered to be a hallmark of cancer cells.
Stachyra P, Grzybowska-Szatkowska L.
europepmc +2 more sources
The Jasmonate Signal Pathway [PDF]
The Plant Cell, 2002 Plant responses to many biotic and abiotic stresses are orchestrated locally and systemically by signaling molecules known as the jasmonates (JAs). JAs also regulate such diverse processes as pollen maturation and wound responses in Arabidopsis.
Turner, J.G. +2 more
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Loss of pancreas upon activated Wnt signaling is concomitant with emergence of gastrointestinal identity [PDF]
, 2016 Organ formation is achieved through the complex interplay between signaling pathways and transcriptional cascades. The canonical Wnt signaling pathway plays multiple roles during embryonic development including patterning, proliferation and ...
Cano, David A. +7 more
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The Signaling Pathway of Rhodopsin [PDF]
Structure, 2007 The signal-transduction mechanism of rhodopsin was studied by molecular dynamics (MD) simulations of the high-resolution, inactive structure in an explicit membrane environment. The simulations were employed to calculate equal-time correlations of the fluctuating interaction energy of residue pairs. The resulting interaction-correlation matrix was used
Yifei Kong, Martin Karplus
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The insulin signalling pathway [PDF]
Current Biology, 2002 A key aim for future research is to identify the hydrophobic motif kinase that phosphorylates PKB, S6K, SGK and to establish how this protein kinase(s) is regulated by PtdIns(3,4,5)P3. It is also becoming obvious that the information obtained by the overexpression of constitutively active and dominant negative mutants of protein kinases is not ...
Jose M. Lizcano, Dario R. Alessi
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Signaling the Pathway to Regeneration [PDF]
Neuron, 2002 Robust axon regeneration occurs after peripheral nerve injury through coordinated activation of a genetic program and local intracellular signaling cascades. Although regeneration-associated genes are being identified with increasing frequency, most aspects of regeneration-associated intracellular signaling remain poorly understood.
William D. Snider +3 more
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Differential Signaling Profiles of MC4R Mutations with Three Different Ligands [PDF]
, 2020 The melanocortin 4 receptor (MC4R) is a key player in hypothalamic weight regulation and energy expenditure as part of the leptin-melanocortin pathway. Mutations in this G protein coupled receptor (GPCR) are the most common cause for monogenetic obesity,
Annibale, Paolo +8 more
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Signaling Pathways in Melanogenesis [PDF]
International Journal of Molecular Sciences, 2016 Melanocytes are melanin-producing cells found in skin, hair follicles, eyes, inner ear, bones, heart and brain of humans. They arise from pluripotent neural crest cells and differentiate in response to a complex network of interacting regulatory pathways. Melanins are pigment molecules that are endogenously synthesized by melanocytes.
Stacey D’Mello +3 more
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Signaling on the endocytic pathway [PDF]
Current Opinion in Cell Biology, 2007 Endocytosis regulates many cellular signaling processes by controlling the number of functional receptors available at the cell surface. Conversely, some signaling processes regulate the endocytic pathway. Furthermore, various cellular signaling events appear to occur on endosome membranes.
Alexander Sorkin, Mark von Zastrow
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