Results 21 to 30 of about 1,476,364 (294)

Downregulation of Interleukin-13 Receptor α2 Inhibits Angiogenic Formation Mediated by Chitinase 3-Like 1 in Late Atherosclerotic Lesions of apoE−/− Mice

Frontiers in Physiology, 2021
Aim: Chitinase 3-like 1 (CHI3L1) has the potential to prompt proliferation and angiogenic formation. Interleukin-13 receptor α2 (IL-13Rα2) was regarded as a receptor of CHI3L1; however, it is unknown whether CHI3L1 adjusts the neovascularization in late ...
Qi Xue, Lei Chen, Jianwu Yu, Kewang Sun, Lifang Ye, Jianlei Zheng, Jianlei Zheng   +6 more
doaj   +1 more source

Engineering Signal Transduction Pathways [PDF]

Cell, 2010
Cells respond to their environment by sensing signals and translating them into changes in gene expression. In recent years, synthetic networks have been designed in both prokaryotic and eukaryotic systems to create new functionalities and for specific applications.
Kiel, Christina, Yus, Eva, Serrano, Luis
openaire   +3 more sources

Supplementation with Pentadecylresorcinol to a High-Fat Diet Increases the Predicted Representation of Enzymes and Metabolic Pathways for Vitamin B12 Synthesis by the Gut Microbiota Of C57bl6 Mice

Ожирение и метаболизм
5-Pentadecylresorcinol (C15) is a natural alkylresorcinol that has been shown to protect against complications caused by imbalanced nutrition. Although the exact mechanisms of beneficial activity of C15 are not known, we assume that the protective ...
A. A. Zabolotneva, M. D. Makeev, A. V. Fesenko, S. A. Roumiantsev, A. V. Shestopalov   +4 more
doaj   +1 more source

Siglec-8 Signals Through a Non-Canonical Pathway to Cause Human Eosinophil Death In Vitro

Frontiers in Immunology, 2021
Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is a glycan-binding receptor bearing immunoreceptor tyrosine-based inhibitory and switch motifs (ITIM and ITSM, respectively) that is selectively expressed on eosinophils, mast cells, and, to a ...
Daniela J. Carroll, Yun Cao, Bruce S. Bochner, Jeremy A. O’Sullivan   +3 more
doaj   +1 more source

Mathematical modeling of regulatory networks of intracellular processes – Aims and selected methods

Computational and Structural Biotechnology Journal, 2023
Regulatory networks structure and signaling pathways dynamics are uncovered in time- and resource consuming experimental work. However, it is increasingly supported by modeling, analytical and computational techniques as well as discrete mathematics and ...
Malgorzata Kardynska, Daria Kogut, Marcin Pacholczyk, Jaroslaw Smieja   +3 more
doaj   +1 more source

The Obesogenic Gut Microbiota as a Crucial Factor Defining the Depletion of Predicted Enzyme Abundance for Vitamin B12 Synthesis in the Mouse Intestine

Biomedicines
Currently, obesity is a critical global public health burden. Numerous studies have demonstrated the regulation of the pathogenesis of obesity and metabolic abnormalities by the gut microbiota and microbial factors; however, their involvement in the ...
Anastasia A. Zabolotneva, Irina M. Kolesnikova, Ilya Yu. Vasiliev, Tatiana V. Grigoryeva, Sergei A. Roumiantsev, Aleksandr V. Shestopalov   +5 more
doaj   +1 more source

Toll-like receptor signaling pathways

Frontiers in Immunology, 2014
Toll-like receptors (TLRs) play crucial roles in the innate immune system by recognizing pathogen-associated molecular patterns derived from various microbes. TLRs signal through the recruitment of specific adaptor molecules, leading to activation of the
Taro eKawai, Takumi eKawasaki
doaj   +1 more source

Interactions of melatonin with various signaling pathways: implications for cancer therapy

Cancer Cell International, 2022
Melatonin is a neuro-hormone with conserved roles in evolution. Initially synthetized as an antioxidant molecule, it has gained prominence as a key molecule in the regulation of the circadian rhythm.
Ainaz Mihanfar, Bahman Yousefi, Bita Azizzadeh, Maryam Majidinia   +3 more
doaj   +1 more source

Bufalin Induces Apoptosis of Human Osteosarcoma U-2 OS Cells through Endoplasmic Reticulum Stress, Caspase- and Mitochondria-Dependent Signaling Pathways

Molecules, 2017
Bone cancer is one of the cancer-related diseases, and there are increased numbers of patients with bone cancer worldwide. Therefore the efficacy of treatment of bone cancer is considered extremely vital.
Ching-Hsiao Lee, Yung-Luen Shih, Mei-Hui Lee, Man-Kuan Au, Yung-Liang Chen, Hsu-Feng Lu, Jing-Gung Chung   +6 more
doaj   +1 more source

Effects of different signaling pathways on odontogenic differentiation of dental pulp stem cells: a review

Frontiers in Physiology, 2023
Dental pulp stem cells (DPSCs) are a type of mesenchymal stem cells that can differentiate into odontoblast-like cells and protect the pulp. The differentiation of DPSCs can be influenced by biomaterials or growth factors that activate different ...
Lisha Zhou, Shuya Zhao, Xianghui Xing
doaj   +1 more source