Results 91 to 100 of about 546,808 (280)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Selection for complex traits leaves little or no classic signatures of selection [PDF]

BMC Genomics, 2014
Selection signatures aim to identify genomic regions underlying recent adaptations in populations. However, the effects of selection in the genome are difficult to distinguish from random processes, such as genetic drift. Often associations between selection signatures and selected variants for complex traits is assumed even though this is rarely (if ...
Kemper, KE, Saxton, SJ, Bolormaa, S, Hayes, BJ, Goddard, ME   +4 more
openaire   +3 more sources

Selection signatures in worldwide sheep populations. [PDF]

PLoS ONE, 2014
The diversity of populations in domestic species offers great opportunities to study genome response to selection. The recently published Sheep HapMap dataset is a great example of characterization of the world wide genetic diversity in sheep.
Maria-Ines Fariello, Bertrand Servin, Gwenola Tosser-Klopp, Rachel Rupp, Carole Moreno, International Sheep Genomics Consortium, Magali San Cristobal, Simon Boitard   +7 more
doaj   +1 more source

Transport signatures of top-gate bound states with strong Rashba-Zeeman effect

, 2017
We suggest a single-mode spin injection scheme in non-ferromagnetic quantum channels utilizing perpendicular strong Rashba spin-orbit and Zeeman fields. By applying a positive top-gate potential in order to inject electrons from the spin-orbit gap to the
Abdullah, Nzar Rauf, Gudmundsson, Vidar, Tang, Chi-Shung, Yu, Yun-Hsuan   +3 more
core   +1 more source

Genome-wide signatures of population bottlenecks and diversifying selection in European wolves [PDF]

, 2013
Genomic resources developed for domesticated species provide powerful tools for studying the evolutionary history of their wild relatives. Here we use 61K single-nucleotide polymorphisms (SNPs) evenly spaced throughout the canine nuclear genome to ...
Greco, C., Jedrzejewska, B., Jedrzejewski, W., Ostrander, E. A., Pilot, M., Randi, E., Sidorovich, V. E., vonHoldt, B. M., Wayne, R. K.   +8 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Resequencing Composite Kazakh Whiteheaded Cattle: Insights into Ancestral Breed Contributions, Selection Signatures, and Candidate Genetic Variants

Animals
This study investigates the genetic architecture of the Kazakh Whiteheaded (KWH) cattle, applying population genetics approaches to resequenced genomes. FST analysis of 66 cattle breeds identified breeds for admixture analysis.
Aigerim K. Khamzina, Alexander V. Igoshin, Zhadyra U. Muslimova, Asset A. Turgumbekov, Damir M. Khussainov, Nikolay S. Yudin, Yessengali S. Ussenbekov, Denis M. Larkin   +7 more
doaj   +1 more source

Probing partonic structure in gamma* gamma -> pi pi near threshold

, 1998
Hadron pair production gamma* gamma -> h hbar in the region where the c.m. energy is much smaller than the photon virtuality can be described in a factorized form, as the convolution of a partonic handbag diagram and generalized distribution amplitudes ...
A. G. Grozin, A. G. Grozin, A. V. Belitsky, A. V. Efremov, A. V. Radyushkin, A. V. Radyushkin, A. V. Radyushkin, B. Pire, G. P. Lepage, G. P. Lepage, I. V. Musatov, J. Blümlein, J. C. Collins, K. Watanabe, M. Diehl, M. Diehl, M. Diehl, M. K. Chase, O. Teryaev, P. Kroll, R. Jakob, S. Ong, T. Gousset, V. M. Budnev, X. Ji, X. Ji   +25 more
core   +4 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

DCMS analysis revealed differential selection signatures in the transboundary Sahiwal cattle for major economic traits

Scientific Reports
The Sahiwal are among the most prominent international transboundary dairy cattle distributed in large numbers between India and Pakistan. With the elapse of more than seven decades after the independence and limited cross-border exchange of Sahiwal ...
Lal Muansangi, Jigyasha Tiwari, Irusappan Ilayaraja, Ishmeet Kumar, Jayesh Vyas, Anil Chitra, Sanchit Pal Singh, Pritam Pal, Gopal Gowane, A. K. Mishra, Anupama Mukherjee, Sabyasachi Mukherjee   +11 more
doaj   +1 more source