Results 101 to 110 of about 546,808 (280)

Rapid adaptation of a polygenic trait after a sudden environmental shift

, 2017
Although a number of studies have shown that natural and laboratory populations initially well-adapted to their environment can evolve rapidly when conditions suddenly change, the dynamics of rapid adaptation are not well understood.
Jain, Kavita, Stephan, Wolfgang
core   +1 more source

High performance computation of landscape genomic models integrating local indices of spatial association [PDF]

, 2014
Since its introduction, landscape genomics has developed quickly with the increasing availability of both molecular and topo-climatic data. The current challenges of the field mainly involve processing large numbers of models and disentangling selection ...
Bruford, Michael W., Colli, Licia, Consortium, the NEXTGEN, Joost, Stéphane, Masembe, Charles, Negrini, Riccardo, Orozco-terWengel, Pablo, Stucki, Sylvie, Taberlet, Pierre   +8 more
core   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Genome-wide selection signatures address trait specific candidate genes in cattle indigenous to arid regions of India

Animal Biotechnology
The peculiarity of Indian cattle lies in milk quality, resistance to diseases and stressors as well as adaptability. The investigation addressed selection signatures in Gir and Tharparkar cattle, belonging to arid ecotypes of India.
Nidhi Sukhija, Anoop Anand Malik, Joel M. Devadasan, Aishwarya Dash, Kangabam Bidyalaxmi, D. Ravi Kumar, M. Kousalaya Devi, Anjali Choudhary, K. K. Kanaka, Rekha Sharma, Shashi Bhushan Tripathi, Saket Kumar Niranjan, Jayakumar Sivalingam, Archana Verma   +13 more
doaj   +1 more source

Characterisation of runs of homozygosity and inbreeding coefficients in the red-brown Korean native chickens [PDF]

Animal Bioscience
Objective The analysis of runs of homozygosity (ROH) has been applied to assess the level of inbreeding and identify selection signatures in various livestock species.
John Kariuki Macharia, Jaewon Kim, Minjun Kim, Eunjin Cho, Jean Pierre Munyaneza, Jun Heon Lee   +5 more
doaj   +1 more source

Exploring signature multiplicity in microarray data using ensembles of randomized trees [PDF]

, 2011
A challenging and novel direction for feature selection research in computational biology is the analysis of signature multiplicity. In this work, we propose to investigate the eect of signature multiplicity on feature importance scores derived from tree-
Geurts, Pierre, Saeys, Yvan
core  

Revealing evolutionary constraints on proteins through sequence analysis

, 2019
Statistical analysis of alignments of large numbers of protein sequences has revealed "sectors" of collectively coevolving amino acids in several protein families.
Bitbol, Anne-Florence, Wang, Shou-Wen, Wingreen, Ned S.   +2 more
core   +3 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Signatures of Selection in Admixed Dairy Cattle in Tanzania

Frontiers in Genetics, 2018
Multiple studies have investigated selection signatures in domestic cattle and other species. However, there is a dearth of information about the response to selection in genomes of highly admixed crossbred cattle in relation to production and adaptation to tropical environments.
Evans Kiptoo Cheruiyot, Evans Kiptoo Cheruiyot, Rawlynce Cheruiyot Bett, Joshua Oluoch Amimo, Yi Zhang, Raphael Mrode, Raphael Mrode, Fidalis D. N. Mujibi, Fidalis D. N. Mujibi   +8 more
openaire   +5 more sources

Detecting Signatures Of Selection In Regulatory Variation

, 2021
A substantial amount of phenotypic diversity results from changes in gene regulation. Understanding how regulatory diversity evolves is therefore a key priority in identifying mechanisms of adaptive change. However, in contrast to powerful models of sequence evolution, we lack a consensus model of regulatory evolution.
Taylor, Jessica, Place, Elsie, Cooney, Christopher, Wright, Alison, Price, Peter, Droguett, Daniela, Kim, Dong, Rogers, Thea, Mank, Judith   +8 more
openaire   +3 more sources