Results 111 to 120 of about 546,808 (280)

Selection Signature Analysis of Whole-Genome Sequences to Identify Genome Differences Between Selected and Unselected Holstein Cattle

Animals
A unique line of Holstein cattle has been maintained without selection in Minnesota since 1964. After many generations, unselected cattle produce less milk, but have better reproductive performance and health traits when compared with contemporary cows ...
Jiarui Cai, Liu Yang, Yahui Gao, George E. Liu, Yang Da, Li Ma   +5 more
doaj   +1 more source

Signatures of selection for resistance to Haemonchus contortus in sheep and goats

BMC Genomics, 2019
Background Gastrointestinal nematode infection (GNI) is the most important disease affecting the small ruminant industry in U.S. The environmental conditions in the southern United States are ideal for the survival of the most pathogenic gastrointestinal
Zaira M. Estrada-Reyes, Yoko Tsukahara, Rodrigo R. Amadeu, Arthur L. Goetsch, Terry A. Gipson, Tilahun Sahlu, Richard Puchala, Zaisen Wang, Steve P. Hart, Raluca G. Mateescu   +9 more
doaj   +1 more source

Breaking the paradigm: Dr Insight empowers signature-free, enhanced drug repurposing [PDF]

, 2019
Motivation: Transcriptome-based computational drug repurposing has attracted considerable interest by bringing about faster and more cost-effective drug discovery.
Baldwin, Nicole E., Chan, Jinyan, Gu, Jinghua, Turner, Jacob A., Wang, Xuan   +4 more
core   +1 more source

Genome-wide signatures of complex introgression and adaptive evolution in the big cats. [PDF]

, 2017
The great cats of the genus Panthera comprise a recent radiation whose evolutionary history is poorly understood. Their rapid diversification poses challenges to resolving their phylogeny while offering opportunities to investigate the historical ...
Antunes, Agostinho, Assis, Juliana, Azevedo, Fernando CC, Bi, Ke, Brassaloti, Ricardo A, Coutinho, Luiz L, Eizirik, Eduardo, Fernandes, Gabriel, Figueiró, Henrique V, Gabaldón, Toni, Hughes, Graham M, Kantek, Daniel, Komissarov, Aleksey, Li, Gang, Linderoth, Tyler, Loska, Damian, Morato, Ronaldo G, Murphy, William J, Nielsen, Rasmus, Nunes, Adauto LV, O'Brien, Stephen J, Oliveira, Guilherme, Pais, Fabiano, Ramalho, Emiliano, Rodrigues, Maíra R, Santos, Sarah HD, Saragüeta, Patricia, Silveira, Leandro, Teeling, Emma C, Teixeira, Rodrigo HF, Trinca, Cristine S, Trindade, Fernanda J, Villela, Priscilla MS   +32 more
core   +5 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Track Extrapolation and Distribution for the CDF-II Trigger System [PDF]

, 2006
The CDF-II experiment is a multipurpose detector designed to study a wide range of processes observed in the high energy proton-antiproton collisions produced by the Fermilab Tevatron.
Abachi, Abe, Acosta, Acosta, Acosta, Acosta, Acosta, Acosta, Acosta, Acosta, Affolder, Anyes Taffard, Ashmanskas, Azzi, Bardi, Christopher Marino, Hyunsoo Kim, James Kraus, John Strologas, Kevin Pitts, Lee Holloway, Mike Kasten, Nathan Eddy, Robert Downing, Sill, Thomson   +25 more
core   +3 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Multiple Instance Hybrid Estimator for Learning Target Signatures

, 2017
Signature-based detectors for hyperspectral target detection rely on knowing the specific target signature in advance. However, target signature are often difficult or impossible to obtain.
Jiao, Changzhe, Zare, Alina
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Polarization selection rules for inter-Landau level transitions in epitaxial graphene revealed by infrared optical Hall effect

, 2013
We report on polarization selection rules of inter-Landau level transitions using reflection-type optical Hall effect measurements from 600 to 4000 cm-1 on epitaxial graphene grown by thermal decomposition of silicon carbide.
Darakchieva, V., Eddy Jr., C. R., Gaskill, D. K., Herzinger, C. M., Hofmann, T., Kühne, P., Myers-Ward, R. L., Schubert, M., Tedesco, J. D., Woollam, J. A., Yakimova, R.   +10 more
core   +1 more source