Simvastatin-Loaded Nanostructured Lipid Carriers as Topical Drug Delivery System for Wound Healing Purposes: Preparation, Characterization, and In Vivo Histopathological Studies [PDF]
Advanced Pharmaceutical Bulletin, 2023 Purpose: Simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, is a commonly used drug to reduce total cholesterol and low-density lipoprotein (LDL) levels.
Seyedeh Maryam Mousavi-Simakani +5 more
doaj +1 more source
Cardioprotective effects of simvastatin‑loaded nano‑niosomes on cardiomyocytes in cardiac ischemia [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریز, 2023 Background. Cardiac ischemia is the major cause of morbidity and mortality which can be increased by Statins. This study aimed to increase the effectiveness of simvastatin in the form of niosomes. Methods. In this study, 25 male Wistar rats were divided
Nahid Aboutaleb +2 more
doaj +1 more source
Journal of Pharmacological Sciences, 2023 Hsp90 is a molecular chaperone that contributes to the activation and stabilization of client proteins. In our previous studies, we found that inhibition of Hsp90 delayed cardiac remodeling during the development of chronic heart failure in animal models.
Tetsuro Marunouchi +7 more
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High dose atorvastatin associated with increased risk of significant hepatotoxicity in comparison to simvastatin in UK GPRD cohort [PDF]
, 2016 Background and Aims: Occasional risk of serious liver dysfunction and autoimmune hepatitis during atorvastatin therapy has been reported. We compared the risk of hepatotoxicity in atorvastatin relative to simvastatin treatment.
Clarke, Alan T. +4 more
core +9 more sources
Simvastatin and Muscle: Zebrafish and Chicken Show that the Benefits are not Worth the Damage
Frontiers in Cell and Developmental Biology, 2022 Simvastatin is one of the most common medicines prescribed to treat human hypercholesterolemia. Simvastatin acts through the inhibition of cholesterol synthesis.
Laise M. Campos +7 more
doaj +1 more source
Baicalein inhibits the pharmacokinetics of simvastatin in rats via regulating the activity of CYP3A4
Pharmaceutical Biology, 2021 Context Baicalein and simvastatin possess similar pharmacological activities and indications. The risk of their co-administration was unclear. Objective The interaction between baicalein and simvastatin was investigated to provide reference and guidance ...
Meng Meng, Xin Li, Xiuwen Zhang, Bin Sun
doaj +1 more source
Pleiotropic effects of simvastatin in physically trained ovariectomized rats
Brazilian Journal of Medical and Biological Research, 2013 This study tested the hypothesis that simvastatin treatment can improve cardiovascular and autonomic functions and membrane lipoperoxidation, with an increased effect when applied to physically trained ovariectomized rats.
N. Bernardes +6 more
doaj +3 more sources
Journal of Orthopaedic Translation, 2021 Background: Simvastatin, a drug for lowering serum cholesterol, has been shown to enhance bone regeneration, but few studies have qualitatively and quantitatively tested its effect when used topically in different animal models.
Lei Dang, Jinglin Zhu, Chunli Song
doaj +1 more source
Simvastatin Attenuated Tumor Growth in Different Pancreatic Tumor Animal Models
Pharmaceuticals, 2022 Newly diagnosed pancreatic cancer increases year by year, while the prognosis of pancreatic cancer has not been very good. Statin drugs were found to have protective effects against a variety of cancers, but their association with pancreatic cancer ...
Chao-Yi Chen +10 more
doaj +1 more source