Results 141 to 150 of about 82,322 (223)

Therapeutic Potential of Saikosaponins in MASLD and Cross‐Organ Protection: A Research Update

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
This review systematically outlines the multi‐target mechanisms of Saikosaponins (SSs) against MASLD, encompassing the regulation of lipid metabolism, insulin resistance, and inflammatory response. Furthermore, it highlights their novel cross‐organ protective effects on the cardiovascular, renal, and central nervous systems, providing therapeutic ...
Jiayao Xiong, Wanyan Tan, Ze Jin, Xiangyu Li, Yuting Chen, Wanting Xie   +5 more
wiley   +1 more source

Targeting aerobic glycolysis combats tyrosine kinase inhibitor resistance of hepatocellular carcinoma

International Journal of Cancer, Volume 158, Issue 3, Page 475-487, 1 February 2026.
Abstract Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer and is frequently identified at a late stage, necessitating systemic therapy. However, resistance to first‐line tyrosine kinase inhibitor therapies, such as sorafenib and lenvatinib, remains a significant clinical challenge.
Longtao Zhao, Junjie Cheng, Yiming Zheng, Jing Wu, Jia Fan, Haixiang Sun, Chao Gao   +6 more
wiley   +1 more source

Naldemedine for the Prevention of Recurrent Acute Pancreatitis: A Randomised, Double‐Blind, Placebo‐Controlled Trial

United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Background and aims No medications are currently approved for the prevention of recurrent acute pancreatitis. This trial evaluated whether naldemedine, a peripherally acting μ‐opioid receptor antagonist, reduces the risk of acute pancreatitis in patients with recurrent acute pancreatitis. Methods This was a multicentre, double‐blinded, placebo‐
Mathias E. Cook, Cecilie S. Knoph, Line Davidsen, Jens B. Frøkjær, Niels H. Bruun, Srdan Novovic, Amer Hadi, Maiken Thyregod Jørgensen, Michael B. Mortensen, Ove Schaffalitzky, Liv B. J. Nielsen, Mark Berner‐Hansen, Asbjørn M. Drewes, Søren S. Olesen   +13 more
wiley   +1 more source

Polypharmacy and potentially inappropriate prescribing in people with type 2 diabetes: An analysis of the Scottish Diabetes Research Network national diabetes cohort

Diabetic Medicine, Volume 43, Issue 2, February 2026.
Abstract Aims This study assesses national trends and, socio‐demographic and clinical factors associated with polypharmacy and potentially in appropriate prescribing among people with type 2 diabetes in Scotland from 2012 to 2022. Methods Retrospective cohort study using nationwide data from the Scottish Care Information – Diabetes database ...
William Berthon, Stuart J. McGurnaghan, Luke A. K. Blackbourn, Amanda de Assuncao Santiago Fernandes, Lauren E. Walker, Rory J. McCrimmon, Helen M. Colhoun, David A. McAllister, Peter Hanlon   +8 more
wiley   +1 more source

Comparative efficacy of pitavastatin and simvastatin in patients with hypercholesterolemia: a meta-analysis of randomized controlled clinical trials

Drug Design, Development and Therapy, 2015
Ning Ma,1,2 Lianqun Cui1 1Department of Cardiology, Shandong Provincial Hospital, Shandong University, 2Department of Cardiology, Heze Municipal Hospital, Heze, Shandong, People's Republic of China Background: Simvastatin is a statin used to lower ...
Ma N, Cui LQ
doaj  

Heart matters: How glucose‐ and lipid‐modulating drugs remodel epicardial adipose tissue accumulation, inflammatory patterns and browning

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 878-894, February 2026.
Abstract Epicardial adipose tissue (EAT) is a metabolically active visceral fat depot located between the myocardium and the visceral pericardium, exerting direct paracrine and vasocrine effects on the heart and coronary vessels. Under physiological conditions, EAT supports myocardial energy metabolism and thermoregulation through fatty acid supply and
Elisabeth Heuboeck, Charnkamal Singh Bhogal, Markus Mandl   +2 more
wiley   +1 more source

GPNMB immunohistochemistry is a useful ancillary tool for the diagnosis of pulmonary lymphangioleiomyomatosis

Histopathology, Volume 88, Issue 3, Page 698-709, February 2026.
We evaluated the diagnostic utility of GPNMB immunohistochemistry in LAM. GPNMB showed strong expression in LAM cells, while the differential diagnostic mimics showed no or only low expression. Based on its 100% sensitivity and specificity in our cohort, GPNMB is a highly reliable immunohistochemical marker for the diagnosis of LAM.
Fatime Szalai, Judit Pápay, Katalin Dezső, Levente Kuthi, Anna Sebestyén, András Khoór, Ildikó Krencz   +6 more
wiley   +1 more source

Skin graft bolstered by negative pressure therapy in chronic wounds: A systematic review

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 2, Page 296-304, February 2026.
NPWT improve the graft take rate of skin graft in chronic ulcer, with an excellent safety and tolerance profile. We have identified various subgroups in which NPWT appears to be more effective, such as venous ulcers, men, patients aged under 65, without arterial disease and those with prior antibiotic therapy.
M. Gamel, M. Gael, A. C. Bursztejn
wiley   +1 more source

Low-dose Simvastatin protects pancreatic cancer cells by promoting mitochondrial autophagy through TFEB. [PDF]

Cell Oncol (Dordr)
Wang Z, Wu D, Zhang Y, Chen W, Fan S, Yang Y, Yang Y, Zu G, An Y, Jin Y, Kang A, Zou Y, Liu Y, Yu X, Qin Y, Xu X, Chen X.   +16 more
europepmc   +1 more source

Structural basis for simvastatin-induced skeletal muscle weakness associated with type 1 ryanodine receptor T4709M mutation. [PDF]

J Clin Invest
Weninger G, Dridi H, Reiken S, Yuan Q, Zhao N, Groom L, Leigh J, Liu Y, Tchagou C, Kang J, Chang A, Luna-Figueroa E, Miotto MC, Wronska A, Dirksen RT, Marks AR.   +15 more
europepmc   +1 more source