Simvastatin Rapidly and Reversibly Inhibits Insulin Secretion in Intact Single-Islet Cultures [PDF]
, 2016 open10Epidemiological studies suggest that statins may promote the development or exacerbation of diabetes, but whether this occurs through inhibition of insulin secretion is unclear.
Alessandro Zambon +9 more
core +2 more sources
Journal of Tissue Engineering, 2013 The aim of this study was to develop a three-dimensional porous bone graft material as vehicle for simvastatin delivery and to investigate its effect on primary human osteoblasts from three donors.
Helen Pullisaar +6 more
doaj +1 more source
Simvastatin protects high glucose-induced H9c2 cells from injury by inducing autophagy
Pharmaceutical Biology, 2020 Context Simvastatin is the first line therapeutic drug for coronary heart disease and atherosclerosis. The protective effect mechanism of simvastatin on cardiomyocytes is unclear.
Lusha E, Hong Jiang
doaj +1 more source
Simvastatin profoundly impairs energy metabolism in primary human muscle cells
Endocrine Connections, 2020 Objectives: Simvastatin use is associated with muscular side effects, and i ncreased risk for type 2 diabetes (T2D). In clinical use, simvastatin is administered in inactive lipophilic lactone-form, which is then converted to active acid-form in the body.
Selina Mäkinen +5 more
doaj +1 more source
Scientific Reports, 2023 Wound healing is one of the most challenging medical circumstances for patients. Pathogens can infect wounds, resulting in tissue damage, inflammation, and disruption of the healing process. Simvastatin was investigated recently, as a wound healing agent
Lamiaa M. Ahmed +3 more
doaj +1 more source
Osteogenic effects of simvastatin-loaded mesoporous titania thin films [PDF]
, 2018 The use of statins in the field of bone regeneration is under current investigation due to the existing demand for non-toxic anabolic agents capable of enhancing bone formation in cases of substantial loss. Simvastatin, a coenzyme currently prescribed in
Angelome, Paula Cecilia +7 more
core +1 more source
Possible Involvement of Akt Activity in Endothelial Dysfunction in Type 2 Diabetic Mice
Journal of Pharmacological Sciences, 2008 We investigated the effects of chronic simvastatin treatment on the impaired endothelium-dependent relaxation seen in aortas from type 2 diabetic mice. Starting at 8 weeks of diabetes, simvastatin (10 mg/kg per day) was administered to diabetic mice for ...
Yasuhiro Takenouchi +3 more
doaj +1 more source
Effect of Pomelo Juice on the Pharmacokinetics of Simvastatin, CYP3A2 Activity and Mdr1a, Mdr1b and Slc21a5 Expressions in Rats [PDF]
Pharmaceutical Sciences, 2019 Background: Food-drug interaction can decrease drug effectiveness or increase risk of drug toxicity. Simvastatin is widely used for treatment of hypercholesterolemia and hypertriglyceridemia.
Kritsakorn Rayasilp +5 more
doaj +1 more source
Lipophilic statins inhibit YAP nuclear localization, co-activator activity and colony formation in pancreatic cancer cells and prevent the initial stages of pancreatic ductal adenocarcinoma in KrasG12D mice. [PDF]
, 2019 We examined the impact of statins on Yes-associated Protein (YAP) localization, phosphorylation and transcriptional activity in human and mouse pancreatic ductal adenocarcinoma (PDAC) cells.
Chang, Hui-Hua +7 more
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Preparation of Simvastatin Hydrogel through Arginine Addition for Drug Delivery System
MATEC Web of Conferences, 2018 Simvastatin is a lipid lowering agent which has been used recently as drug delivery system for stimulating bone regeneration. Because of low therapeutic efficacy and bioavailability, it is necessary to deliver simvastatin by local administration e.g.
Rosyida Niswati Fathmah +3 more
doaj +1 more source