Results 31 to 40 of about 82,322 (223)

Intrinsic Factors Influencing Simvastatin and Simvastatin Acid Pharmacokinetics: Age-Related Studies in Thai Adults and Cross-Population Comparisons. [PDF]

Clin Transl Sci
ABSTRACT Intrinsic factors such as age and ethnicity influence statin pharmacokinetics (PK) and may increase the risk of muscle‐related adverse events. This study investigated the effect of age on the PK of simvastatin (SV) and its active metabolite, simvastatin acid (SVA), in healthy Thai subjects using an LC–MS/MS assay while accounting for key ...
Srimatimanon T, Udomnilobol U, Chariyavilaskul P, Siwamogsatham S, Praditpornsilpa K, Vorasettakarnkij Y, Petchlorlian A, Vanwong N, Piriyapongsa J, Tipsombatboon P, Yodsurang V, Prueksaritanont T.   +11 more
europepmc   +2 more sources

Rethinking Statin Dosage in Coronary Disease. [PDF]

Pharmacol Res Perspect
It is widely acknowledged that a sufficient statin dose is important in the management of symptomatic coronary disease, along with weight reduction and appropriate antithrombotic, blood pressure, and diabetes pharmacotherapy. Mid‐range statin doses have been shown to achieve the maximum improvements in total mortality and have the advantage of greater ...
Dimmitt SB, Stampfer HG, Kennedy MC, Martin JH.   +3 more
europepmc   +2 more sources

Physicians' Experiences as Patients with Statin Side Effects: A Case Series. [PDF]

, 2017
Physicians are among those prescribed statins and therefore, subject to potential statin adverse effects (AEs). There is little information on the impact of statin AEs on physicians affected by them. We sought to assess the character and impact of statin
Golomb, Beatrice Alexandra, Koslik, Hayley J, Meskimen, Athena Hathaway   +2 more
core   +2 more sources

Cytotoxicity and induced apoptosis of a new bioceramic cement containing simvastatin on stem cells from human exfoliated deciduous teeth

Dental Research Journal, 2022
Background: This study aims to compare cytotoxicity and induced apoptosis of a new bioceramic cement containing different concentrations of simvastatin on stem cells from human exfoliated deciduous teeth (SHED).
Iman Parisay, Ali Qeidari, Ehsan Sabouri, Fatemeh Khorakian, Hosein Bagheri   +4 more
doaj   +1 more source

Influence of process variables on the properties of simvastatin self-emulsifying granules obtained through high shear wet granulation [PDF]

, 2015
Improvements of the oral bioavailability of lipophilic drugs can be obtained using lipidic formulations such as the self-emulsifying drug delivery systems.
Benda L., FRANCESCHINIS, ERICA, Perssutti B., REALDON, NICOLA, SANTOMASO, ANDREA CLAUDIO, Voinovich D.   +5 more
core   +1 more source

The impact of simvastatin on pulmonary effectors of Pseudomonas aeruginosa infection. [PDF]

PLoS ONE, 2014
The statin family of cholesterol-lowering drugs is known to have pleiotropic properties which include anti-inflammatory and immunomodulatory effects. Statins exert their pleiotropic effects by altering expression of human immune regulators including pro ...
Emma Hennessy, Julie O'Callaghan, Marlies J Mooij, Claire Legendre, Olga Camacho-Vanegas, Sandra C Camacho, Claire Adams, John A Martignetti, Fergal O'Gara   +8 more
doaj   +1 more source

The Effect of Simvastatin on Acute Phase Functional Outcome of Ischemic Stroke

Aksona, 2022
Introduction: Stroke is one of the leading causes of death and disability worldwide, and especially in Indonesia. Several studies showed the pleiotropic and neuroprotective effect of simvastatin in addition to lowering blood cholesterol levels. Objective:
Fidiana Fidiana, Paulus Sugianto
doaj   +1 more source

Persistent hypertriglyceridemia in statin-treated patients with type 2 diabetes mellitus [PDF]

, 2013
Purpose: This paper reports the results of an audit that assessed the prevalence of residual hypertriglyceridemia and the potential need for intensified management among patients with statin-treated type 2 diabetes mellitus (T2DM) in primary care in the ...
Feher, Michael D., Greener, Mark, Munro, Neil   +2 more
core   +1 more source

Supra and subgingival application of antiseptics or antibiotics during periodontal therapy

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases (gingivitis and periodontitis) are characterized by inflammatory processes which arise as a result of disruption of the balance in the oral ecosystem. According to the current S3 level clinical practice guidelines, therapy of patients with periodontitis involves a stepwise approach that includes the control of the patient ...
Elena Figuero, Jorge Serrano, Nicole Birgit Arweiler, Thorsten Mathias Auschill, Ali Gürkan, Gülnur Emingil   +5 more
wiley   +1 more source

Mood, Personality, and Behavior Changes During Treatment with Statins: A Case Series. [PDF]

, 2015
Psychiatric adverse drug reactions (ADRs) have been reported with statin use, but the literature regarding statin-associated mood/behavioral changes remains limited.
Cham, Stephanie, Golomb, Beatrice A, Koslik, Hayley J   +2 more
core   +1 more source