Results 151 to 160 of about 1,306 (173)

Effects of Sinensetin on Lipid Metabolism in Mature 3T3‐L1 Adipocytes

Phytotherapy Research, 2012
Sinensetin is a rare polymethoxylated flavone found in certain citrus fruits. In this study, we investigated the effects of sinensetin on lipid metabolism in mature 3T3‐L1 adipocytes. Sinensetin decreased the expression of sterol regulatory element‐binding protein 1c (SREBP1c), suggesting its antiadipogeneic property via downreguation of SREBP1c. Also,
Seong-Il, Kang, Hye-Sun, Shin, Hee-Chul, Ko, Se-Jae, Kim   +3 more
openaire   +2 more sources

Sinensetin ameliorates high glucose‐induced diabetic nephropathy via enhancing autophagy in vitro and in vivo

Journal of Biochemical and Molecular Toxicology, 2023
AbstractDiabetic nephropathy (DN) affects around 40% of people with diabetes, the final outcome of which is end‐stage renal disease. The deficiency of autophagy and excessive oxidative stress have been found to participate in the pathogenesis of DN. Sinensetin (SIN) has been proven to have strong antioxidant capability. However, the effect of SIN on DN
Zili Kong, Wenshan Lv, Yunyang Wang, Yajing Huang, Kui Che, Huiqi Nan, Yu Xin, Jiaxuan Wang, Jintao Chen, Yangang Wang, Jingwei Chi   +10 more
openaire   +2 more sources

Sinensetin attenuates IL-1β-induced cartilage damage and ameliorates osteoarthritis by regulating SERPINA3

Food & Function, 2022
Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degeneration, subchondral bone sclerosis, synovial hyperplasia and osteophyte formation as the main pathological manifestations.
Zhendong Liu, Ruizhou Liu, Rui Wang, Jihang Dai, Hui Chen, Jingcheng Wang, Xiaolei Li   +6 more
openaire   +2 more sources

Sinensetin induces apoptosis and autophagy in the treatment of human T-cell lymphoma

Anti-Cancer Drugs, 2019
The present study was carried out to explore the effect of sinensetin in human T-cell lymphoma Jurkat cells and to reveal the underlying molecular mechanisms. We found that sinensetin significantly impeded Jurkat cell proliferation in a dose-dependent and time-dependent manner.
Kok-Tong, Tan, Meng-Xian, Lin, Shih-Chao, Lin, Yu-Tang, Tung, Sheng-Hao, Lin, Chi-Chien, Lin   +5 more
openaire   +2 more sources

Sinensetin Induces Autophagic Cell Death through p53-Related AMPK/mTOR Signaling in Hepatocellular Carcinoma HepG2 Cells

Nutrients, 2020
Sinensetin (SIN) has been reported to exhibit anti-inflammatory and anti-cancer activity. However, the cellular and molecular mechanism by which SIN promotes hepatocellular carcinoma (HCC) cell death remains unclear. In the present study, we investigated
Gon Sup Kim, Ho Jeong Lee, Keun Woo Lee
exaly   +2 more sources

Enhancement of epithelial cell autophagy induced by sinensetin alleviates epithelial barrier dysfunction in colitis

Pharmacological Research, 2019
Intestinal epithelial barrier dysfunction is a key pathology of colitis. Autophagy of epithelial cells maintains homeostasis of the intestinal barrier by inhibiting apoptosis and stimulating degradation of the tight junction protein claudin-2. This study investigated the effects and mechanism of activity of sinensetin, a polymethylated flavonoid ...
Dapeng Chen
exaly   +3 more sources

[Effects of sinensetin on proliferation and apoptosis of human gastric cancer AGS cells].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2011
To study the effects and mechanisms of sinensetin on proliferation and apoptosis of human AGS gastric cancer cells.MTT assay was used to detect the growth inhibition rates of human AGS gastric cancer cells treated with sinsesectin in different concentrations and times. The cell cycle distribution was measured by flow cytometry.
Yang, Dong, Guang, Ji, Aili, Cao, Jianrong, Shi, Hailian, Shi, Jianqun, Xie, Dazheng, Wu   +6 more
openaire   +3 more sources

Vasorelaxant effect of sinensetin via the NO/sGC/cGMP pathway and potassium and calcium channels

Hypertension Research, 2018
Orthosiphon stamineus Benth. (Lambiaceae) is an important traditional plant for the treatment of hypertension. Previous studies have demonstrated that the sinensetin content in O. stamineus is correlated with its vasorelaxant activity. However, there is still very little information regarding the vasorelaxant effect of sinensetin due to a lack of ...
Mun Fei, Yam, Chu Shan, Tan, Ruan, Shibao   +2 more
openaire   +2 more sources

Nobiletin, sinensetin, and tangeretin are the main perpetrators in clementines provoking food-drug interactions in vitro

Food Chemistry, 2020
For clementine juice, previous data indicate a possible food-drug interaction with substrates of key enzymes responsible for drug metabolism (i.e. cytochrome P450 [CYP] 3A4, CYP1A2). However, which compounds in clementine juice are responsible for these effects are unknown.
Johanna Weiss, Giuseppe Gattuso, Davide Barreca, Walter Emil Haefeli   +3 more
openaire   +3 more sources

Sinensetin protects against pulmonary fibrosis via inhibiting Wnt/β-Catenin signaling pathway

Tissue and Cell, 2022
Pulmonary fibrosis is a fatal lung disease characterized by progressive fibroblast proliferation and extensive extracellular matrix (ECM) deposition. Although great efforts have been placed to understand the pathogenesis and explore therapeutic strategies, the treatment options for pulmonary fibrosis are very limited and the prognosis of pulmonary ...
Xuan, Wan, Shuyun, Chen, Penghui, Li, Tiantian, Zhao, Shiguang, Xie, Yan, Fang   +5 more
exaly   +3 more sources