Results 131 to 140 of about 946 (153)
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Journal of Biochemical and Molecular Toxicology, 2023
AbstractDiabetic nephropathy (DN) affects around 40% of people with diabetes, the final outcome of which is end‐stage renal disease. The deficiency of autophagy and excessive oxidative stress have been found to participate in the pathogenesis of DN. Sinensetin (SIN) has been proven to have strong antioxidant capability. However, the effect of SIN on DN
Zili Kong +10 more
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AbstractDiabetic nephropathy (DN) affects around 40% of people with diabetes, the final outcome of which is end‐stage renal disease. The deficiency of autophagy and excessive oxidative stress have been found to participate in the pathogenesis of DN. Sinensetin (SIN) has been proven to have strong antioxidant capability. However, the effect of SIN on DN
Zili Kong +10 more
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Sinensetin induces apoptosis and autophagy in the treatment of human T-cell lymphoma
Anti-Cancer Drugs, 2019The present study was carried out to explore the effect of sinensetin in human T-cell lymphoma Jurkat cells and to reveal the underlying molecular mechanisms. We found that sinensetin significantly impeded Jurkat cell proliferation in a dose-dependent and time-dependent manner.
Kok-Tong, Tan +5 more
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Biological and Pharmaceutical Bulletin, 2015 Sinensetin is a rare polymethoxylated flavone (PMF) found in certain citrus fruits. In this study, we investigated the effects of sinensetin on lipid metabolism in 3T3-L1 cells. Sinensetin promoted adipogenesis in 3T3-L1 preadipocytes growing in incomplete differentiation medium, which did not contain 3-isobutyl-1-methylxanthine.
Seong-Il Kang +2 more
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Pharmacological Research, 2019 Intestinal epithelial barrier dysfunction is a key pathology of colitis. Autophagy of epithelial cells maintains homeostasis of the intestinal barrier by inhibiting apoptosis and stimulating degradation of the tight junction protein claudin-2. This study investigated the effects and mechanism of activity of sinensetin, a polymethylated flavonoid ...
Yong-Jian, Xiong +8 more
exaly +3 more sources
Microchimica Acta, 2008
A disposable screen printed array sensor strip based on self-plasticized lipid membranes combined with chemometric algorithm has been developed and applied for quantification of Orthosiphon stamineus Benth extracts. Sinensetin, a pharmacologically active flavonoid in Orthosiphon stamineus Benth, was quantified with the sensor system using standard ...
Ahmad, MN +7 more
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A disposable screen printed array sensor strip based on self-plasticized lipid membranes combined with chemometric algorithm has been developed and applied for quantification of Orthosiphon stamineus Benth extracts. Sinensetin, a pharmacologically active flavonoid in Orthosiphon stamineus Benth, was quantified with the sensor system using standard ...
Ahmad, MN +7 more
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[Effects of sinensetin on proliferation and apoptosis of human gastric cancer AGS cells].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2011To study the effects and mechanisms of sinensetin on proliferation and apoptosis of human AGS gastric cancer cells.MTT assay was used to detect the growth inhibition rates of human AGS gastric cancer cells treated with sinsesectin in different concentrations and times. The cell cycle distribution was measured by flow cytometry.
Yang, Dong +6 more
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Vasorelaxant effect of sinensetin via the NO/sGC/cGMP pathway and potassium and calcium channels
Hypertension Research, 2018Orthosiphon stamineus Benth. (Lambiaceae) is an important traditional plant for the treatment of hypertension. Previous studies have demonstrated that the sinensetin content in O. stamineus is correlated with its vasorelaxant activity. However, there is still very little information regarding the vasorelaxant effect of sinensetin due to a lack of ...
Mun Fei, Yam +2 more
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Food Chemistry, 2020
For clementine juice, previous data indicate a possible food-drug interaction with substrates of key enzymes responsible for drug metabolism (i.e. cytochrome P450 [CYP] 3A4, CYP1A2). However, which compounds in clementine juice are responsible for these effects are unknown.
Johanna Weiss +3 more
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For clementine juice, previous data indicate a possible food-drug interaction with substrates of key enzymes responsible for drug metabolism (i.e. cytochrome P450 [CYP] 3A4, CYP1A2). However, which compounds in clementine juice are responsible for these effects are unknown.
Johanna Weiss +3 more
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Cardiovascular & Hematological Disorders-Drug Targets, 2022
Background: Plant and their active phytoproducts have been used in modern medicine and playing an important role in the health sectors since a very early age. Human beings need a considerable amount of these plant-based phytochemicals for their health.
Dinesh Kumar Patel, Kanika Patel
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Background: Plant and their active phytoproducts have been used in modern medicine and playing an important role in the health sectors since a very early age. Human beings need a considerable amount of these plant-based phytochemicals for their health.
Dinesh Kumar Patel, Kanika Patel
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Sinensetin protects against pulmonary fibrosis via inhibiting Wnt/β-Catenin signaling pathway
Tissue and Cell, 2022Pulmonary fibrosis is a fatal lung disease characterized by progressive fibroblast proliferation and extensive extracellular matrix (ECM) deposition. Although great efforts have been placed to understand the pathogenesis and explore therapeutic strategies, the treatment options for pulmonary fibrosis are very limited and the prognosis of pulmonary ...
Xuan, Wan +5 more
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