Results 121 to 130 of about 946 (153)
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Die Pharmazie, 2022
In this study, we investigated the immunomodulatory effects of sinensetin (SI) on RAW 264.7 macrophages and cyclophosphamide (CY)-induced immunosuppressed mice. The results showed that SI enhanced macrophage activity and promoted the secretion of NO, IL-1β, and TNF-α in vitro. Compared with the CY-induced immunosuppressed mice, in mice treated with SI,
Yi-Lun Wang, Yi-Lun Wang +2 more
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In this study, we investigated the immunomodulatory effects of sinensetin (SI) on RAW 264.7 macrophages and cyclophosphamide (CY)-induced immunosuppressed mice. The results showed that SI enhanced macrophage activity and promoted the secretion of NO, IL-1β, and TNF-α in vitro. Compared with the CY-induced immunosuppressed mice, in mice treated with SI,
Yi-Lun Wang, Yi-Lun Wang +2 more
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Chemie in Unserer Zeit, 2013
AbstractSinensetin wurde aus kaltgepresstem Orangenschalenöl isoliert und aus Ethanol umkristallisiert. Alle analytischen Spektren sind vollständig entweder im Hauptteil oder im online unter www.chiuz.de zusätzlichen Material zu diesem Artikel wiedergegeben.
Dieter Sicker +2 more
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AbstractSinensetin wurde aus kaltgepresstem Orangenschalenöl isoliert und aus Ethanol umkristallisiert. Alle analytischen Spektren sind vollständig entweder im Hauptteil oder im online unter www.chiuz.de zusätzlichen Material zu diesem Artikel wiedergegeben.
Dieter Sicker +2 more
exaly +3 more sources
Critical Reviews in Food Science and Nutrition, 2023
Sinensetin is among the most ubiquitous polyphenols in citrus fruit and recently has been extensively studied for its ability to prevent or treat diseases. The current literature on the bioavailability of sinensetin and its derivatives was reviewed and the potential ameliorative effects of metabolic syndrome in humans were evaluated. Sinensetin and its
Mutang Zhang +8 more
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Sinensetin is among the most ubiquitous polyphenols in citrus fruit and recently has been extensively studied for its ability to prevent or treat diseases. The current literature on the bioavailability of sinensetin and its derivatives was reviewed and the potential ameliorative effects of metabolic syndrome in humans were evaluated. Sinensetin and its
Mutang Zhang +8 more
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Natural flavonoid sinensetin inhibits cisplatin-induced pyroptosis and attenuates intestinal injury
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2023The demand of exploring strategies to enhance chemotherapy drug efficacy and alleviate adverse effects by using natural compounds is increasing. Sinensetin (SIN) is a kind of natural flavonoids with anti-inflammatory activities. However, its protective impact on chemotherapy-induced adverse effects has not been well demonstrated.
Yue, Li +10 more
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Sinensetin Attenuates LPS-Induced Inflammation by Regulating the Protein Level of IκB-α
Bioscience, Biotechnology and Biochemistry, 2012Sinensetin is one of the polymethoxyflavones (PMFs) having five methoxy groups on the basic benzo-γ-pyrone skeleton with a carbonyl group at the C(4) position. We investigated in this study the anti-inflammatory activity of sinensetin in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
Hye-Sun Shin +2 more
exaly +3 more sources
Biochemical and Biophysical Research Communications, 2002
Multidrug resistance (MDR) cells can be sensitized to anticancer drugs when treated concomitantly with chemosensitizers. In this study, chemosensitizing effects of 5,6,7,3',4'-pentamethoxyflavone (sinensetin) and its analogs were investigated with respect to in vitro efficacy and structure-activity relationship.
Cheol Hee Choi +2 more
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Multidrug resistance (MDR) cells can be sensitized to anticancer drugs when treated concomitantly with chemosensitizers. In this study, chemosensitizing effects of 5,6,7,3',4'-pentamethoxyflavone (sinensetin) and its analogs were investigated with respect to in vitro efficacy and structure-activity relationship.
Cheol Hee Choi +2 more
exaly +3 more sources
International Journal of Biological Macromolecules, 2023
Exploring the interaction of small molecules with therapeutic proteins can provide useful information about development of ligand-protein complexes as synergistically therapeutic platforms. In this study, the interaction of sinensetin with human interferon gamma (IFNγ) was evaluated experimentally and theoretically.
Feiling Feng
exaly +3 more sources
Exploring the interaction of small molecules with therapeutic proteins can provide useful information about development of ligand-protein complexes as synergistically therapeutic platforms. In this study, the interaction of sinensetin with human interferon gamma (IFNγ) was evaluated experimentally and theoretically.
Feiling Feng
exaly +3 more sources
Identification of sinensetin and nobiletin as major antitrypanosomal factors in a citrus cultivar
Experimental Parasitology, 2019Cases of human African trypanosomiasis caused by infection with a protozoan parasite, Trypanosoma brucei, are decreasing due to enhanced surveillance and control. However, effective and safe treatments for this disease are still needed. In this study, we investigated the antitrypanosomal activity of citrus fruit peel.
Masayuki, Nakanishi +4 more
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Food & Function, 2022
Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degeneration, subchondral bone sclerosis, synovial hyperplasia and osteophyte formation as the main pathological manifestations.
Zhendong Liu +6 more
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Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degeneration, subchondral bone sclerosis, synovial hyperplasia and osteophyte formation as the main pathological manifestations.
Zhendong Liu +6 more
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Effects of Sinensetin on Lipid Metabolism in Mature 3T3‐L1 Adipocytes
Phytotherapy Research, 2012Sinensetin is a rare polymethoxylated flavone found in certain citrus fruits. In this study, we investigated the effects of sinensetin on lipid metabolism in mature 3T3‐L1 adipocytes. Sinensetin decreased the expression of sterol regulatory element‐binding protein 1c (SREBP1c), suggesting its antiadipogeneic property via downreguation of SREBP1c. Also,
Seong-Il, Kang +3 more
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