Results 141 to 150 of about 946 (153)

Investigation of synergistic interaction of sinensetin, eupatorin, and 3′-hydroxy-5,6,7,4′-tetramethoxyflavone in vasodilation efficacy

Hypertension Research
Modern medicines often follow a "single-compound, single-target" paradigm, which may not be effective against complex diseases with multifactorial causes. Medicinal plants, such as Orthosiphon stamineus-widely used in Southeast Asia for its significant vasodilatory and antihypertensive properties-offer an alternative.
Mun Fei, Yam, Wan Yin, Tew, Chu Shan, Tan, Qiyue, Qiu, Ruixian, Zhou, Xuye, Wang, Yau Pin, Yap, Wei, Xu, Wen, Xu, Lai Kuan, Teh   +9 more
openaire   +2 more sources

Protective effects of sinensetin against oxidative stress damage induced by AAPH in the brain-gut

Free Radical Research
Sinensetin (SIN for short) is one of the most common polymethoxyflavonoids found in citrus fruits. Recently, it has been extensively studied due to its ability to prevent or treat a wide range of diseases, including diabetes, obesity, neurological disorders, and cancer. Oxidative stress is closely related to the pathogenesis of many diseases.
Tingting, Jin, Menghui, He, Na, Li, Ying, He, Feng, He   +4 more
openaire   +2 more sources

In vivo metabolic fates of sinensetin, 5-demethylsinensetin and their metabolites under diverse conditions

2022
Citrus polymethoxyflavones (PMFs) have attracted great research interest since the recent decade. However, the existed investigations mainly focused on the potential bioactivities of those PMFs, and paid little attention to the in vivo metabolic fates of them.
openaire   +1 more source

Sinensetin Ameliorates Metabolic Syndrome via Regulating Gut Microbiota and Bile Acid Metabolism

Journal of Agricultural and Food Chemistry
The exact mechanism through which dietary flavonoids alleviate metabolic syndrome (MetS) via the gut microbiota remains fully unclear. This study demonstrates that sinensetin markedly impeded the development of MetS and altered hepatic transcriptomic profiles by activating alternative bile acid biosynthesis signaling cascades both in vivo and in vitro.
Min Luan, Sha Bao, Xueling Zhang, Yuhao Huang, Ruinan Yuan, Pengjun Zhong, Mengyuan Liu, Jue Li, Xuefei Liu, Lei Chen, Qingrong Huang, Rihui Wu   +11 more
openaire   +2 more sources

Inhibitory mechanism of sinensetin on α-glucosidase and non-enzymatic glycation: Insights from spectroscopy and molecular docking analyses

International Journal of Biological Macromolecules, 2021
Xiangyu Cao, Yu-Chi Kong, Teng Mu
exaly  

Sinensetin attenuates oxygen–glucose deprivation/reperfusion‐induced neurotoxicity by MAPK pathway in human cerebral microvascular endothelial cells

Journal of Applied Toxicology, 2022
Tiancai Wang
exaly  

Parametric and kinetic study of supercritical carbon dioxide extraction on sinensetin from Orthosiphon stamineus Benth. leaves

Separation Science and Technology, 2022
Ahmad Hazim Abdul Aziz, Nicky Rahmana Putra, Mohd Azizi Che Yunus   +2 more
exaly  

Effects of Sinensetin on Lipid Metabolism in Mature 3T3‐L1 Adipocytes

Phytotherapy Research, 2013
Seong-Il Kang, Hye-Sun Shin, Se-Jae Kim   +2 more
exaly  

Sinensetin isolated from Orthosiphon aristatus inhibits cell proliferation and induces apoptosis in hepatocellular carcinoma cells

Process Biochemistry, 2020
Ashok Kumar Pandurangan, Raaman Nanjian
exaly  

Dietary sinensetin and polymethoxyflavonoids: Bioavailability and potential metabolic syndrome-related bioactivity

Critical Reviews in Food Science and Nutrition
Mutang Zhang, Weidong Bai
exaly