Results 161 to 170 of about 1,306 (173)

Protective effects of sinensetin against oxidative stress damage induced by AAPH in the brain-gut

Free Radical Research
Sinensetin (SIN for short) is one of the most common polymethoxyflavonoids found in citrus fruits. Recently, it has been extensively studied due to its ability to prevent or treat a wide range of diseases, including diabetes, obesity, neurological disorders, and cancer. Oxidative stress is closely related to the pathogenesis of many diseases.
Tingting, Jin, Menghui, He, Na, Li, Ying, He, Feng, He   +4 more
openaire   +2 more sources

Sinensetin Ameliorates Metabolic Syndrome via Regulating Gut Microbiota and Bile Acid Metabolism

Journal of Agricultural and Food Chemistry
The exact mechanism through which dietary flavonoids alleviate metabolic syndrome (MetS) via the gut microbiota remains fully unclear. This study demonstrates that sinensetin markedly impeded the development of MetS and altered hepatic transcriptomic profiles by activating alternative bile acid biosynthesis signaling cascades both in vivo and in vitro.
Min Luan, Sha Bao, Xueling Zhang, Yuhao Huang, Ruinan Yuan, Pengjun Zhong, Mengyuan Liu, Jue Li, Xuefei Liu, Lei Chen, Qingrong Huang, Rihui Wu   +11 more
openaire   +2 more sources

Investigation of synergistic interaction of sinensetin, eupatorin, and 3′-hydroxy-5,6,7,4′-tetramethoxyflavone in vasodilation efficacy

Hypertension Research
Modern medicines often follow a "single-compound, single-target" paradigm, which may not be effective against complex diseases with multifactorial causes. Medicinal plants, such as Orthosiphon stamineus-widely used in Southeast Asia for its significant vasodilatory and antihypertensive properties-offer an alternative.
Mun Fei, Yam, Wan Yin, Tew, Chu Shan, Tan, Qiyue, Qiu, Ruixian, Zhou, Xuye, Wang, Yau Pin, Yap, Wei, Xu, Wen, Xu, Lai Kuan, Teh   +9 more
openaire   +2 more sources

In vivo metabolic fates of sinensetin, 5-demethylsinensetin and their metabolites under diverse conditions

2022
Citrus polymethoxyflavones (PMFs) have attracted great research interest since the recent decade. However, the existed investigations mainly focused on the potential bioactivities of those PMFs, and paid little attention to the in vivo metabolic fates of them.
openaire   +1 more source

Inhibitory mechanism of sinensetin on α-glucosidase and non-enzymatic glycation: Insights from spectroscopy and molecular docking analyses

International Journal of Biological Macromolecules, 2021
Xiangyu Cao, Yuchi Kong, Jianli Liu
exaly  

Parametric and kinetic study of supercritical carbon dioxide extraction on sinensetin from Orthosiphon stamineus Benth. leaves

Separation Science and Technology, 2022
Mohd Azizi Che Yunus, Ahmad Hazim Abdul Aziz, Nicky Rahmana Putra   +2 more
exaly  

Effects of Sinensetin on Lipid Metabolism in Mature 3T3‐L1 Adipocytes

Phytotherapy Research, 2013
Se-Jae Kim
exaly  

Sinensetin isolated from Orthosiphon aristatus inhibits cell proliferation and induces apoptosis in hepatocellular carcinoma cells

Process Biochemistry, 2020
Raman N, Ashok K Pandurangan, Madan Kumar Perumal   +2 more
exaly  

Sinensetin Enhances Adipogenesis and Lipolysis by Increasing Cyclic Adenosine Monophosphate Levels in 3T3-L1 Adipocytes

Biological and Pharmaceutical Bulletin, 2015
Se-Jae Kim, Seong-Il Kang, Hye-Sun Shin   +2 more
exaly  

Dietary sinensetin and polymethoxyflavonoids: Bioavailability and potential metabolic syndrome-related bioactivity

Critical Reviews in Food Science and Nutrition
Gengsheng Xiao, Min Qian, Weidong Bai
exaly