Results 181 to 184 of about 1,840 (184)
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Sinensetin isolated from Orthosiphon aristatus inhibits cell proliferation and induces apoptosis in hepatocellular carcinoma cells

Process Biochemistry, 2020
Abstract Orthosiphon aristatus is a traditional folk medicine extensively used in Southeast Asia because of its various pharmacological effects, including antioxidant, antitumor, and hypoglycemic activities. Orthosiphon extracts have been found to be cytotoxic to hepatocellular carcinoma (HCC) cells, which is attributed to their phytochemical content.
Divakar Samidurai   +4 more
openaire   +1 more source

Investigation of synergistic interaction of sinensetin, eupatorin, and 3′-hydroxy-5,6,7,4′-tetramethoxyflavone in vasodilation efficacy

Hypertension Research
Modern medicines often follow a "single-compound, single-target" paradigm, which may not be effective against complex diseases with multifactorial causes. Medicinal plants, such as Orthosiphon stamineus-widely used in Southeast Asia for its significant vasodilatory and antihypertensive properties-offer an alternative.
Mun Fei, Yam   +9 more
openaire   +2 more sources

In vivo metabolic fates of sinensetin, 5-demethylsinensetin and their metabolites under diverse conditions

2022
Citrus polymethoxyflavones (PMFs) have attracted great research interest since the recent decade. However, the existed investigations mainly focused on the potential bioactivities of those PMFs, and paid little attention to the in vivo metabolic fates of them.
openaire   +1 more source

Sinensetin Inhibits Angiogenesis in Lung Adenocarcinoma via the miR-374c-5p/VEGF-A/VEGFR-2/AKT Axis

Cell Biochemistry and Biophysics
Sinensetin is a product isolated from Orthosiphon aristatus, and its antitumor activities have been well established. This study focused on the role and mechanism of sinensetin in lung adenocarcinoma (LUAD). LUAD cells were treated with various concentrations of sinensetin.
Tao, Ji   +5 more
openaire   +2 more sources

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