Results 231 to 240 of about 865,522 (266)

Single-domain antibodies against SARS-CoV-2 RBD from a two-stage phage screening of universal and focused synthetic libraries. [PDF]

BMC Infect Dis
Chen F, Liu Z, Kang W, Jiang F, Yang X, Yin F, Zhou Z, Li Z.   +7 more
europepmc   +1 more source

Serum immunoglobulin or albumin binding single-domain antibodies that enable tailored half-life extension of biologics in multiple animal species. [PDF]

Front Immunol
Harmsen MM, Ackerschott B, de Smit H.
europepmc   +1 more source

Single-domain antibodies make a difference [PDF]

Science, 2021
A double hit with one antibody construct may avoid viral escape The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, mediates attachment of the virion to the host cell, binding to the ...
X. Saelens, Bert Schepens
semanticscholar   +3 more sources

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Nanobodies: natural single-domain antibodies.

Annual Review of Biochemistry, 2013
Sera of camelids contain both conventional heterotetrameric antibodies and unique functional heavy (H)-chain antibodies (HCAbs). The H chain of these homodimeric antibodies consists of one antigen-binding domain, the VHH, and two constant domains.
S. Muyldermans
semanticscholar   +4 more sources

Humanization of Camelid Single-Domain Antibodies.

Methods in molecular biology, 2022
Humanization of therapeutic antibodies derived from animal immunizations is often required to minimize immunogenicity risks in humans, which can cause potentially harmful and serious side effects and reduce antibody efficacy. Humanization is typically applied to conventional monoclonal antibodies derived in rodents as well as single-domain antibodies ...
T. Sulea
semanticscholar   +3 more sources

Single-Domain Antibodies for the Detection of SARS-CoV-2 Nucleocapsid Protein

Analytical Chemistry, 2021
The goal of this work was to develop recombinantly expressed variable domains derived from camelid heavy-chain antibodies known as single-domain antibodies (sdAbs) directed against the SARS-CoV-2 nucleocapsid protein for incorporation into detection ...
G. Anderson, Jinny L. Liu, T. Esparza, B. Voelker, E. Hofmann, E. Goldman   +5 more
semanticscholar   +1 more source

Delivery of single-domain antibodies into neurons using a chimeric toxin–based platform is therapeutic in mouse models of botulism

Science Translational Medicine, 2021
A detoxified chimeric toxin–based platform delivers therapeutics into neurons and has therapeutic effects in mouse models of botulism. Nontoxic botulinum for drug delivery Botulism is a severe and potentially fatal disease characterized by muscle ...
Shin-Ichiro Miyashita, Jie Zhang, Sicai Zhang, C. Shoemaker, M. Dong   +4 more
semanticscholar   +1 more source

Single-domain antibodies applied as antiviral immunotherapeutics

Journal of Virological Methods, 2023
Viral infections have been the cause of high mortality rates throughout different periods in history. Over the last two decades, outbreaks caused by zoonotic diseases and transmitted by arboviruses have had a significant impact on human health. The emergence of viral infections in different parts of the world encourages the search for new inputs to ...
Nidiane Dantas Reis, Prado, Nairo, Brilhante-Da-Silva, Rosa Maria Oliveira, Sousa, Michelle Suelen da Silva, Morais, Sibele Andrade, Roberto, Marcos Barros, Luiz, Livia Coelho de, Assis, Anna Carolina M, Marinho, Luiz Felipe Lemes de, Araujo, Rafael de Souza, Pontes, Rodrigo Guerino, Stabeli, Carla Freire Celedonio, Fernandes, Soraya Dos Santos, Pereira   +12 more
openaire   +2 more sources

Single-Domain Antibody Theranostics on the Horizon

Journal of Nuclear Medicine, 2022
Single-domain antibody (sdAb) is among the most promising vectors for developing molecular imaging tracers. Several sdAb tracers targeting human epidermal growth factor receptor 2 or programmed death ligand 1 have entered clinical practice. However, radiolabeled single-valent sdAbs generally have high kidney retention, limiting their therapeutic ...
Weijun, Wei, Muhsin H, Younis, Xiaoli, Lan, Jianjun, Liu, Weibo, Cai   +4 more
openaire   +2 more sources

Single-domain antibodies

2009
The antigen-binding entity of an antibody, reduced in size to one single domain, is referred to as a "single-domain antibody". Various strategies have been explored with variable success to arrive at functional sinlge-domain antibodies. The potential of single-domain antibodies, as research tools or in medicine, is reflected by the three companies ...
Muyldermans, Serge, Hassanzadeh Ghassabeh, Gholamreza, Saerens, Dirk   +2 more
openaire   +3 more sources