Results 51 to 60 of about 763,272 (322)

Single-domain antibodies for brain targeting [PDF]

, 2014
Smaller recombinant antibody fragments as single-domain antibodies (sdAbs) are emerging as credible alternatives because of their target specificity, high affinity, and cost-effective recombinant production. sdAbs have been forged into multivalent and multispecif ic therapeutics, or targeting moieties, that are able to shuttle their linked therapeutic ...
Lalatsa, Katerina, Moreira Leite, Diana
core   +3 more sources

Biophysical and biochemical characterization of a VHH-based IgG-like bi- and trispecific antibody platform

mAbs, 2020
Here, we report the characterization of a VHH-derived IgG-like bi- and trispecific antibody platform that essentially relies on the replacement of the VH and VL regions of a conventional antibody by two independently functioning VHH domains. Consequently,
Lukas Pekar, Michael Busch, Bernhard Valldorf, Steffen C. Hinz, Lars Toleikis, Simon Krah, Stefan Zielonka   +6 more
doaj   +1 more source

Research progress and applications of nanobody in human infectious diseases

Frontiers in Pharmacology, 2022
Infectious diseases, caused by pathogenic microorganisms, are capable of affecting crises. In addition to persistent infectious diseases such as malaria and dengue fever, the vicious outbreaks of infectious diseases such as Neocon, Ebola and SARS-CoV-2 ...
Yaxian Mei, Yuanzhi Chen, Jwala P. Sivaccumar, Zhiqiang An, Ningshao Xia, Wenxin Luo   +5 more
doaj   +1 more source

A Single Domain–Based Anti-Her2 Antibody Has Potent Antitumor Activities

Translational Oncology, 2018
Human epidermal growth factor receptor 2 (HER2) is overexpressed in approximately 20% to 30% of breast cancers and various other types of cancers, which plays a vital role in the cancer progression.
Xiaoqiong Wu, Siqi Chen, Limin Lin, Jiayu Liu, Yanlan Wang, Yumei Li, Qing Li, Zhong Wang   +7 more
doaj   +1 more source

Microfluidic multipoles: theory and applications [PDF]

, 2018
Microfluidic multipoles (MFMs) have been realized experimentally and hold promise for "open-space" biological and chemical surface processing. Whereas convective flow can readily be predicted using hydraulic-electrical analogies, the design of advanced ...
Boulais, Étienne, Gervais, Thomas, Goyette, Pierre-Alexandre, Juncker, David, Laberge, Gabriel, Normandeau, Frédéric   +5 more
core   +3 more sources

An Inside Job: Applications of Intracellular Single Domain Antibodies

Biomolecules, 2020
Sera of camelid species contain a special kind of antibody that consists only of heavy chains. The variable antigen binding domain of these heavy chain antibodies can be expressed as a separate entity, called a single domain antibody that is ...
Eline Soetens, Marlies Ballegeer, Xavier Saelens   +2 more
doaj   +1 more source

Single domain antibodies targeting pathological tau protein: Influence of four IgG subclasses on efficacy and toxicity

EBioMedicine, 2022
Summary: Background: Eleven tau immunoglobulin G (IgG) antibodies have entered clinical trials to treat tauopathies, including Alzheimer's disease, but it is unclear which IgG subclass/subtype has the ideal efficacy and safety profile. Only two subtypes,
Erin E. Congdon, Ruimin Pan, Yixiang Jiang, Leslie A. Sandusky-Beltran, Andie Dodge, Yan Lin, Mengyu Liu, Min-Hao Kuo, Xiang-Peng Kong, Einar M. Sigurdsson   +9 more
doaj   +1 more source

A common theme in interaction of bacterial immunoglobulin-binding proteins with immunoglobulins illustrated in the equine system [PDF]

, 2008
The M protein of Streptococcus equi subsp. equi known as fibrinogen-binding protein (FgBP) is a cell wall-associated protein with antiphagocytic activity that binds IgG. Recombinant versions of the seven equine IgG subclasses were used to investigate the
Abi-Rached, Berge, Boschwitz, Boschwitz, Bruggemann, Burton, Burton, Carlsson, Deisenhofer, DeLano, Flock, Flock, Galan, Galan, Galan, Ghetie, Harrington, Herr, Jonsson, Lancet, Lewis, Lindmark, Meehan, Meehan, Meehan, Meehan, Meehan, Morton, Newton, Nitsche-Schmitz, Pleass, Pleass, Ramsland, Recht, Sauer-Eriksson, Sheoran, Sheoran, Taylor, Timoney, Timoney, Timoney, van Loghem, Wagner, Wagner, Wagner, Waller, Wines, Wines, Wolbink, Åkerström   +49 more
core   +4 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source