Results 31 to 40 of about 7,630,796 (295)

Single-domain antibodies for biomedical applications [PDF]

Immunopharmacology and Immunotoxicology, 2015
Single-domain antibodies are the smallest antigen-binding units of antibodies, consisting either only of one variable domain or one engineered constant domain that solely facilitates target binding. This class of antibody derivatives comprises naturally occurring variable domains derived from camelids and sharks as well as engineered human variable or ...
Krah, Simon, Schröter, Christian, Zielonka, Stefan, Empting, Martin, Valldorf, Bernhard, Kolmar, Harald   +5 more
openaire   +3 more sources

Correction to “Micromagnetic models of pseudo-single domain grains of magnetite near the Verwey Transition” [PDF]

, 1999
Domain structures of small pseudo-single domain (PSD) magnetite near the Verwey transition (Tυ) at ≈120 K were modeled using an unconstrained three-dimensional micromagnetic algorithm.
A. R. Muxworthy, W. Williams, Muxworthy, A. R., Williams, Wyn; id_orcid   +3 more
core   +1 more source

Llama-Derived Single Domain Antibodies Specific for Abrus Agglutinin

Toxins, 2011
Llama derived single domain antibodies (sdAb), the recombinantly expressed variable heavy domains from the unique heavy-chain only antibodies of camelids, were isolated from a library derived from llamas immunized with a commercial abrin toxoid ...
James P. Carney, Rachael Bernstein, Eric A. E. Garber, Jennifer L. Walker, Thomas W. O’Brien, Alena Calm, Jinny L. Liu, Ellen R. Goldman, Scott Walper, Dan Zabetakis, George P. Anderson   +10 more
doaj   +1 more source

Effect of magnetostatic interactions on the hysteresis parameters of single-domain and psuedo-single domain grains [PDF]

, 2003
From experiments it is known that magnetostatic interactions between grains strongly affect the magnetic behavior of samples. However, because of the difficulty in predicting the nonlinear behavior, the effect of interactions has been largely ignored ...
Davinder Virdee, Adrian Muxworthy, Williams, W., Wyn Williams, Muxworthy, A.R., Muxworthy, A., Williams, W.; id_orcid, Virdee, D.   +7 more
core   +1 more source

Selection of functional human antibodies from retroviral display libraries [PDF]

, 2004
Antibody library technology represents a powerful tool for the discovery and design of antibodies with high affinity and specificity for their targets.
Álvarez-Vallina, Luis, Christian J. Buchholz, Carsten Finger, Klaus Cichutek, Compte, Marta, Johannes H. Urban, Finger, Carsten, Urban, Johannes H., Richard M. Schneider, Schneider, Richard M., Cichutek, Klaus, Buchholz, Christian, Marta Compte   +12 more
core   +1 more source

Single-domain antibodies as therapeutics for solid tumor treatment

Acta Pharmaceutica Sinica B
Single-domain antibodies (sdAbs), initially identified in camelids or sharks and commonly referred to as nanobodies or VNARs, have emerged as a promising alternative to conventional therapeutic antibodies.
Mingkai Wang, Tianlei Ying, Yanling Wu
doaj   +1 more source

Isolation and characterization of camelid single-domain antibodies against HER2

BMC Research Notes, 2018
Objective To isolate and characterize novel high-affinity llama single-domain antibodies against human HER2. Results We immunized a llama with human HER2, constructed a phage-displayed VHH library from the lymphocytes of the animal, and isolated six ...
Greg Hussack, Shalini Raphael, Michael J. Lowden, Kevin A. Henry   +3 more
doaj   +1 more source

Cross-Reactive Fc-Fused Single-Domain Antibodies to Hemagglutinin Stem Region Protect Mice from Group 1 Influenza a Virus Infection

Viruses, 2022
The continued evolution of influenza viruses reduces the effectiveness of vaccination and antiviral drugs. The identification of novel and universal agents for influenza prophylaxis and treatment is an urgent need. We have previously described two potent
Daria V. Voronina, Dmitry V. Shcheblyakov, Irina A. Favorskaya, Ilias B. Esmagambetov, Alina S. Dzharullaeva, Amir I. Tukhvatulin, Olga V. Zubkova, Olga Popova, Vladislav Y. Kan, Alina S. Bandelyuk, Maxim M. Shmarov, Denis Y. Logunov, Boris S. Naroditskiy, Aleksandr L. Gintsburg   +13 more
doaj   +1 more source

Linking Single Domain Antibodies that Recognize Different Epitopes on the Same Target

Biosensors, 2012
Single domain antibodies (sdAb) are the recombinantly expressed variable regions from the heavy-chain-only antibodies found in camelids and sharks.
Ellen R. Goldman, Nina C. Long, Jinny L. Liu, Dan Zabetakis, Richard H. Glaven, George P. Anderson   +5 more
doaj   +1 more source

Multimeric single-domain antibody complexes protect against bunyavirus infections

eLife, 2020
The World Health Organization has included three bunyaviruses posing an increasing threat to human health on the Blueprint list of viruses likely to cause major epidemics and for which no, or insufficient countermeasures exist.
Paul J Wichgers Schreur, Sandra van de Water, Michiel Harmsen, Erick Bermúdez-Méndez, Dubravka Drabek, Frank Grosveld, Kerstin Wernike, Martin Beer, Andrea Aebischer, Olalekan Daramola, Sara Rodriguez Conde, Karen Brennan, Dorota Kozub, Maiken Søndergaard Kristiansen, Kieran K Mistry, Ziyan Deng, Jan Hellert, Pablo Guardado-Calvo, Félix A Rey, Lucien van Keulen, Jeroen Kortekaas   +20 more
doaj   +1 more source