Results 21 to 30 of about 628,481 (260)

Biotechnological applications of recombinant single-domain antibody fragments

Microbial Cell Factories, 2011
Background Single-domain antibody fragments possess structural features, such as a small dimension, an elevated stability, and the singularity of recognizing epitopes non-accessible for conventional antibodies that make them interesting for several ...
de Marco Ario
doaj   +1 more source

Single domain antibody multimers confer protection against rabies infection.

PLoS ONE, 2013
Post-exposure prophylactic (PEP) neutralizing antibodies against Rabies are the most effective way to prevent infection-related fatality. The outer envelope glycoprotein of the Rabies virus (RABV) is the most significant surface antigen for generating ...
Bhargavi M Boruah, Dawei Liu, Duan Ye, Tie-Jun Gu, Chun-Lai Jiang, Mingsheng Qu, Edward Wright, Wei Wang, Wen He, Changzhen Liu, Bin Gao   +10 more
doaj   +1 more source

Engineering a novel IgG-like bispecific antibody against enterovirus A71

Biochemistry and Biophysics Reports, 2020
Frequent outbreaks of enterovirus A71 (EVA71) occur in the Asia-Pacific area, and these are closely associated with severe neurological symptoms in young children. No effective antiviral therapy is currently available for the treatment of EVA71 infection.
Hsiang-Ching Wang, Hui-Chen Hung, Peng-Nien Huang, Yu-An Kung, Sung-Nien Tseng, Yun-Ming Wang, Shin-Ru Shih, John Tsu-An Hsu   +7 more
doaj   +1 more source

Single-domain antibodies for biomedical applications [PDF]

Immunopharmacology and Immunotoxicology, 2015
Single-domain antibodies are the smallest antigen-binding units of antibodies, consisting either only of one variable domain or one engineered constant domain that solely facilitates target binding. This class of antibody derivatives comprises naturally occurring variable domains derived from camelids and sharks as well as engineered human variable or ...
Krah, Simon, Schröter, Christian, Zielonka, Stefan, Empting, Martin, Valldorf, Bernhard, Kolmar, Harald   +5 more
openaire   +3 more sources

Llama-Derived Single Domain Antibodies Specific for Abrus Agglutinin

Toxins, 2011
Llama derived single domain antibodies (sdAb), the recombinantly expressed variable heavy domains from the unique heavy-chain only antibodies of camelids, were isolated from a library derived from llamas immunized with a commercial abrin toxoid ...
James P. Carney, Rachael Bernstein, Eric A. E. Garber, Jennifer L. Walker, Thomas W. O’Brien, Alena Calm, Jinny L. Liu, Ellen R. Goldman, Scott Walper, Dan Zabetakis, George P. Anderson   +10 more
doaj   +1 more source

Single-domain antibodies as therapeutics for solid tumor treatment

Acta Pharmaceutica Sinica B
Single-domain antibodies (sdAbs), initially identified in camelids or sharks and commonly referred to as nanobodies or VNARs, have emerged as a promising alternative to conventional therapeutic antibodies.
Mingkai Wang, Tianlei Ying, Yanling Wu
doaj   +1 more source

Isolation and characterization of camelid single-domain antibodies against HER2

BMC Research Notes, 2018
Objective To isolate and characterize novel high-affinity llama single-domain antibodies against human HER2. Results We immunized a llama with human HER2, constructed a phage-displayed VHH library from the lymphocytes of the animal, and isolated six ...
Greg Hussack, Shalini Raphael, Michael J. Lowden, Kevin A. Henry   +3 more
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Linking Single Domain Antibodies that Recognize Different Epitopes on the Same Target

Biosensors, 2012
Single domain antibodies (sdAb) are the recombinantly expressed variable regions from the heavy-chain-only antibodies found in camelids and sharks.
Ellen R. Goldman, Nina C. Long, Jinny L. Liu, Dan Zabetakis, Richard H. Glaven, George P. Anderson   +5 more
doaj   +1 more source

Multimeric single-domain antibody complexes protect against bunyavirus infections

eLife, 2020
The World Health Organization has included three bunyaviruses posing an increasing threat to human health on the Blueprint list of viruses likely to cause major epidemics and for which no, or insufficient countermeasures exist.
Paul J Wichgers Schreur, Sandra van de Water, Michiel Harmsen, Erick Bermúdez-Méndez, Dubravka Drabek, Frank Grosveld, Kerstin Wernike, Martin Beer, Andrea Aebischer, Olalekan Daramola, Sara Rodriguez Conde, Karen Brennan, Dorota Kozub, Maiken Søndergaard Kristiansen, Kieran K Mistry, Ziyan Deng, Jan Hellert, Pablo Guardado-Calvo, Félix A Rey, Lucien van Keulen, Jeroen Kortekaas   +20 more
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Cross-Reactive Fc-Fused Single-Domain Antibodies to Hemagglutinin Stem Region Protect Mice from Group 1 Influenza a Virus Infection

Viruses, 2022
The continued evolution of influenza viruses reduces the effectiveness of vaccination and antiviral drugs. The identification of novel and universal agents for influenza prophylaxis and treatment is an urgent need. We have previously described two potent
Daria V. Voronina, Dmitry V. Shcheblyakov, Irina A. Favorskaya, Ilias B. Esmagambetov, Alina S. Dzharullaeva, Amir I. Tukhvatulin, Olga V. Zubkova, Olga Popova, Vladislav Y. Kan, Alina S. Bandelyuk, Maxim M. Shmarov, Denis Y. Logunov, Boris S. Naroditskiy, Aleksandr L. Gintsburg   +13 more
doaj   +1 more source